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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical and Translational Research in Head and Neck Cancer—2nd Edition
edited by Young J. Kim
submission deadline 25 Jun 2026 | Viewed by 52 | Submission Open
Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics
(This special issue belongs to the Section Clinical Research of Cancer)
New Strategies for Molecular Targeted Therapy in Multiple Myeloma
edited by Daniele Caracciolo
submission deadline 26 Jun 2026 | Viewed by 42 | Submission Open
Keywords: multiple myeloma; molecular target; drug target; signaling pathway; immunotherapeutic strategy; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers submission deadline 30 Jun 2026 | 9 articles | Viewed by 26768 | Submission Open
Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in the Prevention and Treatment of Liver Cancer
edited by Ewa Janczewska
submission deadline 30 Jun 2026 | 8 articles | Viewed by 19784 | Submission Open
Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization
(This special issue belongs to the Section Cancer Therapy)
New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy
edited by Kazunari Murakami and
submission deadline 30 Jun 2026 | 7 articles | Viewed by 18406 | Submission Open
Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor
(This special issue belongs to the Section Cancer Therapy)
Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment submission deadline 30 Jun 2026 | 8 articles | Viewed by 17408 | Submission Open
Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19
(This special issue belongs to the Section Cancer Therapy)
Advances in Bacteria and Cancer
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 15431 | Submission Open
Keywords: pathogenic bacteria; microbiota; tumor-associated bacteria; probiotics; oncogenesis; metastasis; chemotherapy; cancerous cells; tumor microenvironment; cell signaling
(This special issue belongs to the Section Tumor Microenvironment)
New Insights into Thyroid Cancer Surgery
edited by and Francesca Torresan
submission deadline 30 Jun 2026 | 6 articles | Viewed by 10923 | Submission Open
Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring
(This special issue belongs to the Section Cancer Therapy)
Gynecologic Oncology: Clinical and Translational Research
edited by , Pasquale Lombardi and Gaia Giannone
submission deadline 30 Jun 2026 | 7 articles | Viewed by 9990 | Submission Open
Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors
(This special issue belongs to the Section Cancer Therapy)
Clinical Diagnosis, Treatment, and Prognosis of Uveal Melanoma
edited by Josep Maria Caminal Mitjana
submission deadline 30 Jun 2026 | 5 articles | Viewed by 8988 | Submission Open
Keywords: uveal melanoma; choroidal melanoma; gene expression profiling; immunotherapy; metastasis; radiotherapy; liquid biopsy; circulating tumor cells; brachytherapy; next-generation sequencing; proton therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 8124 | Submission Open
Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies submission deadline 30 Jun 2026 | 4 articles | Viewed by 6000 | Submission Open
Keywords: abdominal oncologic surgery; minimally invasive techniques; laparoscopy; robotics; fluorescence; artificial intelligence; augmented vision; peritoneal carcinomatosis; intraperitoneal chemotherapy; liquid biopsy
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Regulation in Hematologic Malignancies
edited by Travis S. Johnson
submission deadline 30 Jun 2026 | 3 articles | Viewed by 5925 | Submission Open
Keywords: epigenetic regulation; hematologic malignancies; DNA methylation; non-coding RNA; therapeutic targeting
(This special issue belongs to the Section Tumor Microenvironment)
The Progress of Pancreatectomy for Pancreatic Cancer Treatment submission deadline 30 Jun 2026 | 4 articles | Viewed by 5797 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatectomy timing in multimodal regimen; minimally invasive pancreatectomy for PDAC; pancreatectomy and resectability; extended pancreatectomy; vascular resection and reconstruction; outcome research— pancreatectomy for cancer in unselected patient cohorts; interaction of postoperative complications and preoperative or adjuvant therapy; postoperative pancreatic fistula
(This special issue belongs to the Section Clinical Research of Cancer)
The Role of Neutrophils in Tumor Progression and Metastasis
edited by and Leah M. Cook
submission deadline 30 Jun 2026 | 3 articles | Viewed by 5008 | Submission Open
Keywords: neutrophils; innate immunity; tumor; microenvironment; metastasis; targeted therapeutics
(This special issue belongs to the Section Cancer Metastasis)
Applications of Ex Vivo Microscopy in Cancer Detection and Diagnosis
edited by J. Quincy Brown
submission deadline 30 Jun 2026 | 3 articles | Viewed by 3352 | Submission Open
Keywords: microscopy; cancer; optical sectioning; diagnosis; detection
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Exploring Immunotherapy in Colorectal Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 2569 | Submission Open
Keywords: colorectal cancer; immunotherapy; immune checkpoint inhibitors; mismatch repair; microsatellite instability; biomarkers
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Neuroscience of Brain Tumors
edited by Zefferino Rossini, and Maria Pia Tropeano
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2333 | Submission Open
Keywords: neurosurgery; neuroscience; brain tumors (gliomas; meningiomas; and pituitary tumors); neural pathway; neuroimaging; neurogenetics
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice
edited by , Silvia Martina Ferrari and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2284 | Submission Open
Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities
(This special issue belongs to the Section Clinical Research of Cancer)
Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention
edited by Adam Barsouk
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2127 | Submission Open
Keywords: epidemiology; disparities; oncology; cancer; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Chemoprevention Advances in Cancer (2nd Edition)
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2016 | Submission Open
Keywords: cancer prevention; chemoprevention; nutrition and cancer; bio-active food components; natural products; non-toxic anticancer agents; precision nutrition in cancer; tumor metabolomics; gut microbiome in cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Integrating Precision Medicine with Nanotechnology to Overcome Drug Resistance in Cancer
edited by Yan Li
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1683 | Submission Open
Keywords: precision medicine; nanotechnology; drug resistance
(This special issue belongs to the Section Methods and Technologies Development)
Advances in PET/CT for Predicting Cancer Outcomes
edited by Ahmad Shariftabrizi
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1449 | Submission Open
Keywords: FDG PET/CT; PSMA PET/CT; dotatate PET/CT; tumor heterogeneity; radiomics; CAR T-cell therapy; rare tumors; radiogenomics; immunotherapy; targeted therapy; PET physics; radiotracer metabolism
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Neurofibromatosis
edited by Yunjia Chen and Yulong Fu
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1246 | Submission Open
Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1
(This special issue belongs to the Section Molecular Cancer Biology)
New Strategies for the Treatment of Melanoma and Non-Melanoma Skin Cancer submission deadline 30 Jun 2026 | 2 articles | Viewed by 1062 | Submission Open
Keywords: melanoma; non-melanoma skin cancer; immunotherapy; anti-PD-1 antibody; BRAF/MEK inhibitors; racial differences; prognosis
(This special issue belongs to the Section Cancer Therapy)
Unveiling the Complexity of Hepato-Biliary-Pancreatic Cancers: From Pathogenesis to Management
edited by and Luiz Zerbini
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1046 | Submission Open
Keywords: hepatocellular carcinoma (HCC); cholangiocarcinoma; pancreatic ductal adenocarcinoma (PDAC); tumour microenvironment; molecular biomarkers; therapeutic resistance; cancer immunotherapy; early cancer detection; precision oncology; targeted therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Clinical Pathology of Lung Cancer (2nd Edition)
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1027 | Submission Open
Keywords: lung cancer; pathology; diagnosis; treatment; targeted therapies; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Neurofibromatosis Type 1 (NF1) Related Tumors (2nd Edition) submission deadline 30 Jun 2026 | 1 articles | Viewed by 802 | Submission Open
Keywords: NF1; tumorigenesis; cancer stem cells; targeted therapy; tumor microenvironment; epigenetics; case report; metastasis; clinical trials
(This special issue belongs to the Section Tumor Microenvironment)
Classification, Risk Assessment and Clinical Management of Malignant Thyroid Nodules: 2nd Edition
edited by Claudio Spinelli and Marco Ghionzoli
submission deadline 30 Jun 2026 | 1 articles | Viewed by 637 | Submission Open
Keywords: thyroid nodule; thyroid cancer; guidelines; surgery
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Advances in Epidemiology of Childhood Cancer
edited by Rafael Peris-Bonet, and Adela Cañete
submission deadline 30 Jun 2026 | 1 articles | Viewed by 412 | Submission Open
Keywords: childhood cancer epidemiology; childhood cancer registries; environmental causes of childhood cancer; genetic epidemiology; molecular epidemiology; survival of children with cancer; quality of life; social determinants and inequalities; information technologies and statistical innovations
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Understanding the Molecular Basis and Immunobiology of Renal Cell Carcinoma and Exploring Novel Therapeutic Strategies
edited by
submission deadline 30 Jun 2026 | Viewed by 394 | Submission Open
Keywords: renal cell carcinoma; molecular basis; immunobiology; tumor microenvironment; immunotherapy; targeted therapy; metastasis; precision medicine; biomarkers; non-coding RNA; miRNA; prognosis; molecular diagnostics; translational research
(This special issue belongs to the Section Cancer Therapy)
Recent Updates on Treatment of Uveal Melanoma
edited by Richard D. Carvajal, Shaheer Khan and Brian Peter Marr
submission deadline 30 Jun 2026 | Viewed by 333 | Submission Open
Keywords: uveal melanoma; systemic therapies; surgical innovations; radiotherapy; genetic and molecular insights; translational research
(This special issue belongs to the Section Cancer Therapy)
Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)
edited by Hiromichi Ito
submission deadline 30 Jun 2026 | Viewed by 325 | Submission Open
Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging
(This special issue belongs to the Section Cancer Therapy)
Innovative Treatments Based on Genomic Aberrations in Leukemia and Lymphoma submission deadline 30 Jun 2026 | Viewed by 321 | Submission Open
Keywords: leukemia; lymphoma; AI and predictive modeling; MRD; B-ALL; DLBCL; genomics; treatment  
(This special issue belongs to the Section Cancer Therapy)
Surgical Perspectives in Lung Cancer: From Technique to Outcome
edited by Takahiro Homma and Hyun Koo Kim
submission deadline 30 Jun 2026 | Viewed by 305 | Submission Open
Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery
(This special issue belongs to the Section Cancer Therapy)
Cancer Inhibitory Receptors: Targeting Tumor Microenvironment Therapeutically
edited by and Alok Kumar
submission deadline 30 Jun 2026 | Viewed by 299 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy; tumor microenvironment; inhibitory receptors; immune system; T cells; malignant cells; therapeutic targets
(This special issue belongs to the Section Cancer Therapy)
Role of BCL-2 Family Proteins in Cancer: Therapeutic Advancements and Challenges
edited by Sajid Khan
submission deadline 30 Jun 2026 | Viewed by 282 | Submission Open
Keywords: BCL-2 family proteins; apoptosis; BH3 mimetics; thrombocytopenia; proteolysis-targeting chimeras; drug resistance; combination therapy; targeted drug delivery
(This special issue belongs to the Section Cancer Therapy)
Signaling Networks Controlling Ovarian Cancer Progression and Response to Therapy
edited by and Roberta Mastrantonio
submission deadline 30 Jun 2026 | Viewed by 257 | Submission Open
Keywords: ovarian cancer; patient-derived models; mesothelium; ascites; immunotherapy; chemotherapy; drug resistance; metastasis; peritoneum; p53; BRCA; signaling pathway; metabolism
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Neoadjuvant Therapy for Urologic Cancer
edited by Carlo Messina
submission deadline 30 Jun 2026 | Viewed by 253 | Submission Open
Keywords: neoadjuvant treatment; bladder cancer; prostate cancer; renal cell carcinoma; penile cancers; immunotherapy; antibody– drug conjugates
(This special issue belongs to the Section Cancer Therapy)
Targeted Radiotracers for Molecular Imaging and Therapy in Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 192 | Submission Open
Keywords: theranostic; radionuclide molecular imaging; targeted therapy; specificity; selectivity; personalized medicine; radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
Soft Tissue Sarcomas—New Diagnostic and Therapeutic Perspectives Through Clinical Genomic Profiling
edited by and
submission deadline 30 Jun 2026 | Viewed by 187 | Submission Open
Keywords: soft tissue sarcoma; molecular profiling; cancer genomics; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiology for the Detection, Diagnosis, and Management of Breast Cancer
edited by Takouhie Catherine Maldjian and Mary M. Salvatore
submission deadline 30 Jun 2026 | Viewed by 155 | Submission Open
Keywords: breast cancer; radiology; breast imaging; mammography; MRI; ultrasound; AI; radiomics; diagnosis; treatment response; image-guided biopsy
(This special issue belongs to the Section Methods and Technologies Development)
The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment submission deadline 30 Jun 2026 | Viewed by 153 | Submission Open
Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies
(This special issue belongs to the Section Cancer Therapy)
Hepatocellular Carcinoma: Clinical Evidence and Emerging Therapeutic Benefits
edited by
submission deadline 30 Jun 2026 | Viewed by 120 | Submission Open
Keywords: artificial intelligence; downstaging; immunotherapy; multidisciplinary approaches; risk factors; nutrition
(This special issue belongs to the Section Cancer Therapy)
Urological Cancer: Epidemiology and Genetics
edited by Ilir Agalliu and Evan Kovac
submission deadline 30 Jun 2026 | Viewed by 119 | Submission Open
Keywords: environmental factors; lifestyle; genetic susceptibility; biomarkers; prostate cancer; bladder cancer; kidney cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Circadian Rhythms, Cancers and Chronotherapy (2nd Edition)
edited by , and Esra Tasali
submission deadline 30 Jun 2026 | Viewed by 118 | Submission Open
Keywords: drug development and chronotherapy; chemotherapy; immunotherapy; targeted agents; radiotherapy; surgery; circadian host or tumor biomarkers; electronic patient-reported outcomes; circadian rhythms and sleep; sex- and age specificities; clinical trial designs; mathematical models and artificial intelligence; digital healthcare; telemedicine and logistics
(This special issue belongs to the Section Cancer Therapy)
Updates on Anti-Cancer Drug Research
edited by and Mónica Fernandes
submission deadline 30 Jun 2026 | Viewed by 108 | Submission Open
Keywords: anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding  RNAs; multi-omics data
(This special issue belongs to the Section Cancer Drug Development)
Emerging Therapies for Germ Cell Tumors
edited by and Krinio Giannikou
submission deadline 30 Jun 2026 | Viewed by 107 | Submission Open
Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Tumor Microenvironment of Thyroid Carcinoma
edited by
submission deadline 30 Jun 2026 | Viewed by 105 | Submission Open
Keywords: thyroid cancer; tumor immune microenvironment (TIME); double-negative T cells (DN T cells); tumor-associated macrophages (TAMs)
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Pancreatic Cancer: Exploring Biomarkers and Prognostic Predictors
edited by
submission deadline 30 Jun 2026 | Viewed by 104 | Submission Open
Keywords: pancreatic cancer; biomarkers; diagnosis; prognosis; liquid biopsy; proteomics; metabolomics; tumor microenvironment; genetic aberrations/mutations; inflammatory markers
(This special issue belongs to the Section Cancer Biomarkers)
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