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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Applications of Ex Vivo Microscopy in Cancer Detection and Diagnosis
edited by J. Quincy Brown
submission deadline 30 Jun 2026 | 3 articles | Viewed by 4279 | Submission Open
Keywords: microscopy; cancer; optical sectioning; diagnosis; detection
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Cancer Data and Statistics: 2nd Edition
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3604 | Submission Open
Keywords: cancer registries; cancer incidence; cancer survival; population-based studies; cancer risk factors
(This special issue belongs to the Section Cancer Informatics and Big Data)
Integrating Precision Medicine with Nanotechnology to Overcome Drug Resistance in Cancer
edited by Yan Li
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3124 | Submission Open
Keywords: precision medicine; nanotechnology; drug resistance
(This special issue belongs to the Section Methods and Technologies Development)
Neuroscience of Brain Tumors
edited by Zefferino Rossini, and Maria Pia Tropeano
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3035 | Submission Open
Keywords: neurosurgery; neuroscience; brain tumors (gliomas; meningiomas; and pituitary tumors); neural pathway; neuroimaging; neurogenetics
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in PET/CT for Predicting Cancer Outcomes
edited by Ahmad Shariftabrizi
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3020 | Submission Open
Keywords: FDG PET/CT; PSMA PET/CT; dotatate PET/CT; tumor heterogeneity; radiomics; CAR T-cell therapy; rare tumors; radiogenomics; immunotherapy; targeted therapy; PET physics; radiotracer metabolism
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice
edited by , Silvia Martina Ferrari and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2776 | Submission Open
Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities
(This special issue belongs to the Section Clinical Research of Cancer)
Chemoprevention Advances in Cancer (2nd Edition)
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2660 | Submission Open
Keywords: cancer prevention; chemoprevention; nutrition and cancer; bio-active food components; natural products; non-toxic anticancer agents; precision nutrition in cancer; tumor metabolomics; gut microbiome in cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Classification, Risk Assessment and Clinical Management of Malignant Thyroid Nodules: 2nd Edition
edited by Claudio Spinelli and Marco Ghionzoli
submission deadline 30 Jun 2026 | 3 articles | Viewed by 2372 | Submission Open
Keywords: thyroid nodule; thyroid cancer; guidelines; surgery
(This special issue belongs to the Section Clinical Research of Cancer)
New Strategies for the Treatment of Melanoma and Non-Melanoma Skin Cancer submission deadline 30 Jun 2026 | 2 articles | Viewed by 2369 | Submission Open
Keywords: melanoma; non-melanoma skin cancer; immunotherapy; anti-PD-1 antibody; BRAF/MEK inhibitors; racial differences; prognosis
(This special issue belongs to the Section Cancer Therapy)
Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention
edited by Adam Barsouk
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2351 | Submission Open
Keywords: epidemiology; disparities; oncology; cancer; prevention
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Neurofibromatosis
edited by Yunjia Chen and Yulong Fu
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1750 | Submission Open
Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1
(This special issue belongs to the Section Molecular Cancer Biology)
Plasma and Cancer Treatment
edited by and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1520 | Submission Open
Keywords: cold atmospheric plasma (CAP); cancer treatment; plasma medicine; reactive oxygen species (ROS); apoptosis; tumor; non-thermal plasma; plasma oncology; cancer and molecular biology; clinical translation; in vivo/preclinical
(This special issue belongs to the Section Cancer Therapy)
Clinical Pathology of Lung Cancer (2nd Edition)
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1388 | Submission Open
Keywords: lung cancer; pathology; diagnosis; treatment; targeted therapies; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Unveiling the Complexity of Hepato-Biliary-Pancreatic Cancers: From Pathogenesis to Management
edited by and Luiz Zerbini
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1292 | Submission Open
Keywords: hepatocellular carcinoma (HCC); cholangiocarcinoma; pancreatic ductal adenocarcinoma (PDAC); tumour microenvironment; molecular biomarkers; therapeutic resistance; cancer immunotherapy; early cancer detection; precision oncology; targeted therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Neurofibromatosis Type 1 (NF1) Related Tumors (2nd Edition) submission deadline 30 Jun 2026 | 1 articles | Viewed by 1123 | Submission Open
Keywords: NF1; tumorigenesis; cancer stem cells; targeted therapy; tumor microenvironment; epigenetics; case report; metastasis; clinical trials
(This special issue belongs to the Section Tumor Microenvironment)
Urological Cancer: Epidemiology and Genetics
edited by Ilir Agalliu and Evan Kovac
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1008 | Submission Open
Keywords: environmental factors; lifestyle; genetic susceptibility; biomarkers; prostate cancer; bladder cancer; kidney cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Targeted Radiotracers for Molecular Imaging and Therapy in Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 997 | Submission Open
Keywords: theranostic; radionuclide molecular imaging; targeted therapy; specificity; selectivity; personalized medicine; radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
Genetic Alterations and Features in the Development of Gastrointestinal Cancer
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 943 | Submission Open
Keywords: gastrointestinal cancers; genetic alteration; epigenetic regulation; the mechanism of tumorigenesis; precision treatment
(This special issue belongs to the Section Molecular Cancer Biology)
PARP Inhibitors in Cancer Therapy
edited by and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 908 | Submission Open
Keywords: PARP inhibitors; cancer therapy; DNA damage repair; drug discovery
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Epidemiology of Childhood Cancer
edited by Rafael Peris-Bonet, and Adela Cañete
submission deadline 30 Jun 2026 | 1 articles | Viewed by 801 | Submission Open
Keywords: childhood cancer epidemiology; childhood cancer registries; environmental causes of childhood cancer; genetic epidemiology; molecular epidemiology; survival of children with cancer; quality of life; social determinants and inequalities; information technologies and statistical innovations
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Soft Tissue Sarcomas—New Diagnostic and Therapeutic Perspectives Through Clinical Genomic Profiling submission deadline 30 Jun 2026 | 1 articles | Viewed by 639 | Submission Open
Keywords: soft tissue sarcoma; molecular profiling; cancer genomics; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Pleural Mesothelioma: From Diagnosis to Treatment submission deadline 30 Jun 2026 | 1 articles | Viewed by 548 | Submission Open
Keywords: pleural mesothelioma; histological classification; molecular characteristics; immunotherapy; chemotherapy; radiotherapy; surgery; targeted therapy; emerging therapies
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiology for the Detection, Diagnosis, and Management of Breast Cancer
edited by Takouhie Catherine Maldjian and Mary M. Salvatore
submission deadline 30 Jun 2026 | 1 articles | Viewed by 501 | Submission Open
Keywords: breast cancer; radiology; breast imaging; mammography; MRI; ultrasound; AI; radiomics; diagnosis; treatment response; image-guided biopsy
(This special issue belongs to the Section Methods and Technologies Development)
Radiation Therapy in Oncology
edited by Jerzy Wydmański
submission deadline 30 Jun 2026 | 1 articles | Viewed by 430 | Submission Open
Keywords: radiotherapy; radiation injury; systemic therapy; immunotherapy; cancer; concurrent chemoradiotherapy; stereotactic radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Understanding the Molecular Basis and Immunobiology of Renal Cell Carcinoma and Exploring Novel Therapeutic Strategies
edited by
submission deadline 30 Jun 2026 | Viewed by 426 | Submission Open
Keywords: renal cell carcinoma; molecular basis; immunobiology; tumor microenvironment; immunotherapy; targeted therapy; metastasis; precision medicine; biomarkers; non-coding RNA; miRNA; prognosis; molecular diagnostics; translational research
(This special issue belongs to the Section Cancer Therapy)
Surgical Perspectives in Lung Cancer: From Technique to Outcome
edited by Takahiro Homma and Hyun Koo Kim
submission deadline 30 Jun 2026 | Viewed by 393 | Submission Open
Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery
(This special issue belongs to the Section Cancer Therapy)
Recent Updates on Treatment of Uveal Melanoma
edited by Richard D. Carvajal, Shaheer Khan and Brian Peter Marr
submission deadline 30 Jun 2026 | Viewed by 389 | Submission Open
Keywords: uveal melanoma; systemic therapies; surgical innovations; radiotherapy; genetic and molecular insights; translational research
(This special issue belongs to the Section Cancer Therapy)
Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)
edited by Hiromichi Ito
submission deadline 30 Jun 2026 | Viewed by 372 | Submission Open
Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging
(This special issue belongs to the Section Cancer Therapy)
Innovative Treatments Based on Genomic Aberrations in Leukemia and Lymphoma submission deadline 30 Jun 2026 | Viewed by 347 | Submission Open
Keywords: leukemia; lymphoma; AI and predictive modeling; MRD; B-ALL; DLBCL; genomics; treatment  
(This special issue belongs to the Section Cancer Therapy)
Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration
edited by and Robert Förster
submission deadline 30 Jun 2026 | 1 articles | Viewed by 323 | Submission Open
Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Inhibitory Receptors: Targeting Tumor Microenvironment Therapeutically
edited by and Alok Kumar
submission deadline 30 Jun 2026 | Viewed by 320 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy; tumor microenvironment; inhibitory receptors; immune system; T cells; malignant cells; therapeutic targets
(This special issue belongs to the Section Cancer Therapy)
Role of BCL-2 Family Proteins in Cancer: Therapeutic Advancements and Challenges
edited by Sajid Khan
submission deadline 30 Jun 2026 | Viewed by 304 | Submission Open
Keywords: BCL-2 family proteins; apoptosis; BH3 mimetics; thrombocytopenia; proteolysis-targeting chimeras; drug resistance; combination therapy; targeted drug delivery
(This special issue belongs to the Section Cancer Therapy)
Proton and Light Ion Therapy for Cancer
edited by Oliver Jäkel
submission deadline 30 Jun 2026 | Viewed by 291 | Submission Open
Keywords: novel beam delivery concepts; image guidance; adaptive therapy; in vivo monitoring; radiobiological studies with protons and light ions; clinical studies; outcome reports
(This special issue belongs to the Section Cancer Therapy)
Signaling Networks Controlling Ovarian Cancer Progression and Response to Therapy
edited by and Roberta Mastrantonio
submission deadline 30 Jun 2026 | Viewed by 285 | Submission Open
Keywords: ovarian cancer; patient-derived models; mesothelium; ascites; immunotherapy; chemotherapy; drug resistance; metastasis; peritoneum; p53; BRCA; signaling pathway; metabolism
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Neoadjuvant Therapy for Urologic Cancer
edited by Carlo Messina
submission deadline 30 Jun 2026 | Viewed by 268 | Submission Open
Keywords: neoadjuvant treatment; bladder cancer; prostate cancer; renal cell carcinoma; penile cancers; immunotherapy; antibody– drug conjugates
(This special issue belongs to the Section Cancer Therapy)
Cancer Disparities and Health Equity: Challenges, Insights, and Transformative Strategies
edited by and Jane Ussher
submission deadline 30 Jun 2026 | Viewed by 220 | Submission Open
Keywords: scientific censorship; terminated grants; identity politics and health; LGBTQI+ cancer health equity; LGBTQI+ cancer survivorship and care
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Circadian Rhythms, Cancers and Chronotherapy (2nd Edition)
edited by , and Esra Tasali
submission deadline 30 Jun 2026 | Viewed by 189 | Submission Open
Keywords: drug development and chronotherapy; chemotherapy; immunotherapy; targeted agents; radiotherapy; surgery; circadian host or tumor biomarkers; electronic patient-reported outcomes; circadian rhythms and sleep; sex- and age specificities; clinical trial designs; mathematical models and artificial intelligence; digital healthcare; telemedicine and logistics
(This special issue belongs to the Section Cancer Therapy)
The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment submission deadline 30 Jun 2026 | Viewed by 185 | Submission Open
Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies
(This special issue belongs to the Section Cancer Therapy)
Advances in Pancreatic Cancer: Exploring Biomarkers and Prognostic Predictors
edited by
submission deadline 30 Jun 2026 | Viewed by 147 | Submission Open
Keywords: pancreatic cancer; biomarkers; diagnosis; prognosis; liquid biopsy; proteomics; metabolomics; tumor microenvironment; genetic aberrations/mutations; inflammatory markers
(This special issue belongs to the Section Cancer Biomarkers)
Hepatocellular Carcinoma: Clinical Evidence and Emerging Therapeutic Benefits
edited by
submission deadline 30 Jun 2026 | Viewed by 144 | Submission Open
Keywords: artificial intelligence; downstaging; immunotherapy; multidisciplinary approaches; risk factors; nutrition
(This special issue belongs to the Section Cancer Therapy)
Emerging Therapies for Germ Cell Tumors
edited by and Krinio Giannikou
submission deadline 30 Jun 2026 | Viewed by 142 | Submission Open
Keywords: testicular cancer; embryonal carcinoma; germ cell tumors; cisplatin; immunotherapy; epigenetics; microRNA; chemoresistance; animal models; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
A New Road for Cancer Drug Discovery submission deadline 30 Jun 2026 | Viewed by 137 | Submission Open
Keywords: cancer drug discovery; artificial intelligence in drug discovery and development; targeted therapy; precision oncology; targeted protein degrades; small-molecule therapeutics; immuno-oncology; undruggable targets; drug resistance mechanisms; combination therapy
(This special issue belongs to the Section Cancer Drug Development)
Updates on Anti-Cancer Drug Research
edited by and Mónica Fernandes
submission deadline 30 Jun 2026 | Viewed by 136 | Submission Open
Keywords: anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding  RNAs; multi-omics data
(This special issue belongs to the Section Cancer Drug Development)
Tumor Microenvironment of Thyroid Carcinoma
edited by
submission deadline 30 Jun 2026 | Viewed by 133 | Submission Open
Keywords: thyroid cancer; tumor immune microenvironment (TIME); double-negative T cells (DN T cells); tumor-associated macrophages (TAMs)
(This special issue belongs to the Section Tumor Microenvironment)
Basic and Translational Science in Ocular Oncology
edited by Anthony B. Daniels, and
submission deadline 30 Jun 2026 | Viewed by 131 | Submission Open
Keywords: ocular oncology; eye cancer; tumors; melanoma; retinoblastoma; hemangioma; hemangioblastoma; lymphoma
(This special issue belongs to the Section Cancer Pathophysiology)
Arginine and Cancers: Molecular Mechanisms and Anticancer Therapy submission deadline 30 Jun 2026 | Viewed by 130 | Submission Open
Keywords: arginine; cancer; therapy; immunotherapy; metabolism
(This special issue belongs to the Section Cancer Drug Development)
Genomics and Genetics in Brain Cancer Treatment, Diagonals, and Prognosis
edited by
submission deadline 30 Jun 2026 | Viewed by 124 | Submission Open
Keywords: genomics; genetics; brain tumor; brain cancer; glioblastoma multiform; glioma; cancer diagnosis; cancer prognosis
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Evolving Management of Gastroesophageal Cancers: From Local Therapies to Precision Oncology
edited by
submission deadline 30 Jun 2026 | Viewed by 118 | Submission Open
Keywords: gastric cancer; esophageal cancer; immunotherapy targeted therapy; radiation therapy; surgical oncology; precision oncology; molecular biomarkers; multimodal treatment
(This special issue belongs to the Section Cancer Therapy)
Human Carcinogens—New Insights from Occupational Exposure submission deadline 30 Jun 2026 | Viewed by 116 | Submission Open
Keywords: occupational carcinogens; chemical exposure; cancer prevention; artificial intelligence (AI); workplace health policy
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression
edited by Andrej Veljković, and
submission deadline 30 Jun 2026 | Viewed by 116 | Submission Open
Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets
(This special issue belongs to the Section Tumor Microenvironment)
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