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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiosensitivity and Radiotoxicity in Cancer

edited by

Alexandros Georgakilas

submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open

Keywords: radiation therapy; clinical outcome; radiosensitivity; radiotoxicity; biomarkers; bioinformatics; systems biology

(This special issue belongs to the Section Methods and Technologies Development)

Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)

edited by

Edwin Bölke

, Tanja Fehm and

Stefanie Corradini

submission deadline 31 Jan 2026 | Viewed by 81 | Submission Open

Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival

(This special issue belongs to the Section Cancer Therapy)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer

edited by

Ning Zhou

and

Sashi Debnath

submission deadline 31 Jan 2026 | Viewed by 73 | Submission Open

Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)

(This special issue belongs to the Section Methods and Technologies Development)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 31 Jan 2026 | Viewed by 63 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Transformative Drug Innovations Reshaping Myeloma Treatment

edited by Despina Fotiou

submission deadline 31 Jan 2026 | Viewed by 59 | Submission Open

Keywords: multiple myeloma; cellular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer and Stem Cells

edited by Leandro Marcelo Martinez

submission deadline 31 Jan 2026 | Viewed by 59 | Submission Open

Keywords: breast cancer; cancer stem cells; tumor microenvironment; metastasis; therapeutic strategies; in vitro models

(This special issue belongs to the Section Molecular Cancer Biology)

Nutrition in Survivors with Advanced Cancer: The Role of Appetite, Muscle Wasting, Obesity, and Altered Body Composition

edited by Egidio Del Fabbro

submission deadline 31 Jan 2026 | Viewed by 58 | Submission Open

Keywords: advanced cancer; nutrition; wasting; body composition; multimodal

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Diagnosis and Biomarkers for Hematologic Malignancies

edited by

Luis Colomo

and

Francesco Lanza

submission deadline 31 Jan 2026 | Viewed by 52 | Submission Open

Keywords: hematologic malignancies; diagnosis; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Neoadjuvant Therapy for Urologic Cancer

edited by Marlon Perera and David Chen

submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open

Keywords: urologic oncology; neoadjuvant therapy; treatment; improved survival

(This special issue belongs to the Section Cancer Therapy)

Curative Therapies for Non-Small and Small Cell Lung Cancers

edited by John Michael Varlotto

submission deadline 31 Jan 2026 | Viewed by 50 | Submission Open

Keywords: radiotherapy; surgery; early stage NSCLC; oligometastases; immunotherapy; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Immune Profiling in Gastrointestinal Cancers: Implications for Precision Immunotherapy

edited by

Paulina Mertowska

submission deadline 31 Jan 2026 | Viewed by 40 | Submission Open

Keywords: gastrointestinal cancer; immune profiling; immunocompetent cells; personalized immunotherapy; biomarkers; precision medicine; tumor microenvironment; tumor-infiltrating lymphocytes; immune checkpoint inhibitors; microbiota– immunity interactions; single-cell analysis; spatial transcriptomics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications

edited by Francesco Mattioli

submission deadline 31 Jan 2026 | Viewed by 40 | Submission Open

Keywords: laryngeal cancers; diagnosis; laryngeal surgery; transoral laser microsurgery; transoral robotic surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Approaches in the Management of Gynecological Cancers

edited by

Mikel Gorostidi

Martina Aida Angeles

and

Ignacio Zapardiel

submission deadline 31 Jan 2026 | Viewed by 34 | Submission Open

Keywords: gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; surgical management; clinical management

(This special issue belongs to the Section Cancer Therapy)

Conversion Surgery for Initially Unresectable, Locally Advanced, Metastatic or Recurrent Gastrointestinal Cancers

edited by

Takashi Murakami

submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open

Keywords: conversion surgery; locally advanced disease; metastatic disease; chemotherapy; radiotherapy; immunotherapy; heptobiliary-pancreatic cancers; gastrointestinal tract cancers

(This special issue belongs to the Section Clinical Research of Cancer)

Updates on Imaging of Common Urogenital Neoplasms 2nd Edition

edited by Athina C Tsili

submission deadline 31 Jan 2026 | Viewed by 30 | Submission Open

Keywords: urogenital neoplasms; renal cell carcinoma; prostatic neoplasms; urinary bladder neoplasms; testicular neoplasms; uterine neoplasms; ovarian neoplasms; ultrasonography; computed tomography; magnetic resonance imaging

(This special issue belongs to the Section Methods and Technologies Development)

Therapy for HER2 Breast Cancer

edited by

Junji Tsurutani

and Sandra M. Swain

submission deadline 1 Feb 2026 | Viewed by 25 | Submission Open

Keywords: antibody– drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan

(This special issue belongs to the Section Cancer Therapy)

New Insights into Cancer Radiotherapy

edited by

Michael L. F. Lerch

submission deadline 10 Feb 2026 | 1 articles | Viewed by 349 | Submission Open

Keywords: radiotherapy; X-rays; gamma rays; external beam radiation therapy; brachytherapy; palliative care; intensity-modulated radiotherapy (IMRT); stereotactic body radiotherapy (SBRT); proton therapy

(This special issue belongs to the Section Cancer Therapy)

Recent Developments in the Field of Radiotherapy Treatment for Lung Cancer

edited by Ioannis C. Maroulis

submission deadline 10 Feb 2026 | 1 articles | Viewed by 347 | Submission Open

Keywords: lung cancer; radiotherapy; non-small-cell lung cancer (NSCLC)

(This special issue belongs to the Section Cancer Therapy)

Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies

edited by

Chencheng Xie

submission deadline 10 Feb 2026 | Viewed by 155 | Submission Open

Keywords: liver cancer; molecular research; biomarkers; targeted therapy; translational research

(This special issue belongs to the Section Tumor Microenvironment)

Exercise and Cancer Treatment: The Clinical Application of Exercise Oncology

edited by

Helena Batatinha

submission deadline 10 Feb 2026 | Viewed by 89 | Submission Open

Keywords: exercise oncology; cancer therapy; immunotherapy; patient outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Metronomic Chemotherapy in Female Cancers

edited by

Luca Roncati

submission deadline 14 Feb 2026 | 1 articles | Viewed by 849 | Submission Open

Keywords: metronomic chemotherapy; female cancers; anti-tumor mechanisms; clinical trials and outcomes; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Advances in Surgical Treatment of Gynecological Cancers

edited by

Denis Querleu

, Joanna P. Kacperczyk-Bartnik and

Aleksandra Strojna

submission deadline 14 Feb 2026 | Viewed by 185 | Submission Open

Keywords: gynecological oncology; image-guided surgery; lymphadenectomy; minimally invasive surgery; ovarian cancer surgery; patient outcomes; perioperative care; precision surgery; radical hysterectomy; robotic-assisted surgery; surgical oncology

(This special issue belongs to the Section Cancer Therapy)

New Strategies in Diagnosis and Treatments for Brain Tumors: 2nd Edition

edited by Sven Rainer Kantelhardt

submission deadline 15 Feb 2026 | 4 articles | Viewed by 10379 | Submission Open

Keywords: glioma; brain tumor; molecular guided therapy; personal medicine; radiomics; digital analysis; artificial intelligence; intraoperative imaging; surgical resection

(This special issue belongs to the Section Cancer Therapy)

New and Emerging Strategies for Targeting Genomic Instability and Overcoming Drug Resistance in Lung Cancer

edited by Kelsie L. Thu

submission deadline 15 Feb 2026 | 5 articles | Viewed by 9361 | Submission Open

Keywords: lung cancer; genomic instability; drug resistance; treatment strategy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions

edited by

Daniela Cornelia Lazăr

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1013 | Submission Open

Keywords: neoadjuvant therapy; hepatopancreatobiliary malignancies; hepatocellular carcinoma; pancreatic cancer; cholangiocarcinoma; chemotherapy; radiotherapy; immunotherapy; targeted therapies; personalized treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in Precision Medicine: Targeting Known and Emerging Oncogenic Targets in Lung Cancer (2nd Edition)

edited by

Tianhong Li

submission deadline 15 Feb 2026 | Viewed by 74 | Submission Open

Keywords: precision oncology; lung cancer; oncogenic target; targeted therapy; biomarker; diagnosis

(This special issue belongs to the Section Molecular Cancer Biology)

Genetic Changes in CNS Neoplasms

edited by Kimberly Bojanowski Hoang

submission deadline 15 Feb 2026 | Viewed by 49 | Submission Open

Keywords: primary brain tumor; secondary brain tumor; metastasis; glioma; genetics; genomics; CNS; neoplasms

(This special issue belongs to the Section Cancer Biomarkers)

Epigenetics and Non-Coding RNAs in Multiple Myeloma

edited by

Rui Bergantim

submission deadline 15 Feb 2026 | Viewed by 11 | Submission Open

Keywords: multiple myeloma; epigenetics; non-coding RNAs; microRNAs (miRNAs); long non-coding RNAs (lncRNAs); circular RNAs (circRNAs); DNA methylation; histone modifications; drug resistance; precision medicine

Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition)

edited by

Anna Kakehashi

and Min Gi

submission deadline 18 Feb 2026 | 1 articles | Viewed by 1499 | Submission Open

Keywords: cancer; screening; diagnosis; anti-cancer; drugs; mechanisms of carcinogenesis; chemopreventive agents

(This special issue belongs to the Section Cancer Therapy)

Gaps in Cancer Cachexia Research

edited by Jose M. Garcia and

Lindsey J. Anderson

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7631 | Submission Open

Keywords: cancer cachexia; physical function; innovative models; rehabilitation; patient-reported outcomes; gender; aging; skeletal muscle; brain; adipose tissue

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Chronic Intestinal Inflammation and Cancers (2nd Edition)

edited by Livia Biancone and David Laharie

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1593 | Submission Open

Keywords: colorectal cancer; chronic inflammation; inflammatory bowel disease; inflammation-associated dysplasia; outcomes; cancer molecular pathways

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Fibroblasts as Playmakers of Cancer Progression: Current Knowledge and Future Perspectives (2nd Edition)

edited by

Kenichiro Ishii

submission deadline 20 Feb 2026 | Viewed by 160 | Submission Open

Keywords: tumor microenvironment; reactive stroma; fibroblasts; cancer progression; heterotypic interactions between cancer cells and fibroblasts; reactive stroma-targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular Tumor Boards: Promise and Limitations for Personalized Cancer Therapy: 2nd Edition

edited by

Claudia Paret

submission deadline 20 Feb 2026 | Viewed by 106 | Submission Open

Keywords: targeted therapy; drug repositioning; biomarkers; basket trials; precision oncology; personalized medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Multiple Myeloma: Recent Advances in Diagnosis, Analysis and Therapeutic Management: 2nd Edition

edited by

Juan Manuel Rosa-Rosa

submission deadline 20 Feb 2026 | Viewed by 106 | Submission Open

Keywords: multiple myeloma (MM); hematologic malignancies; next-generation sequencing; heterogeneous disease; tumor heterogeneity; genomic landscape; outcomes; novel treatments; clinical trial

(This special issue belongs to the Section Cancer Therapy)

Quality of Life and Side Effects Management in Cancer Treatment (3rd Edition)

edited by

António Araújo

submission deadline 20 Feb 2026 | Viewed by 97 | Submission Open

Keywords: cancer treatment adverse events; quality of life in cancer patients; chemotherapy adverse events; target therapy adverse events; immunotherapy adverse events; hormonotherapy adverse events; chemotherapy-induced nausea and vomiting; cancer pain

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advanced Surgical Modalities in Breast Cancer Treatment

edited by Jan Žatecký

submission deadline 20 Feb 2026 | Viewed by 54 | Submission Open

Keywords: breast cancer surgery; breast cancer localization; breast conserving surgery; mastectomy; oncoplastic surgery; axillary lymph node staging; sentinel lymph node biopsy; targeted axillary dissection

(This special issue belongs to the Section Clinical Research of Cancer)

Radiation Therapy for Modern Management of Bone Metastases (2nd Edition)

edited by

Francesco Cellini

submission deadline 25 Feb 2026 | Viewed by 78 | Submission Open

Keywords: radiotherapy; palliative care; steretactic radiotherapy; SBRT; immunotherapy; chemotherapy; oligometastases

(This special issue belongs to the Section Cancer Therapy)

Minimal Residual Disease in Solid Tumors: Emerging Technologies and Clinical Applications

edited by

Sofia Agelaki

Kleita Michaelidou

and Aristeidis Boukouris

submission deadline 25 Feb 2026 | Viewed by 59 | Submission Open

Keywords: minimal residual disease (MRD); solid tumors; circulating tumor DNA (ctDNA); liquid biopsy; tumor-informed assays; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Harnessing the Gut Microbiome to Improve Colorectal Cancer Outcomes

edited by Carole S. Richard

submission deadline 25 Feb 2026 | Viewed by 40 | Submission Open

Keywords: colorectal cancer (CRC); gut microbiome; screening; CRC cells; the gut microenvironment; oncological outcomes

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in the Treatment of Gastrointestinal (GI) Cancers

edited by

Yoshiyasu Kono

submission deadline 27 Feb 2026 | Viewed by 52 | Submission Open

Keywords: gastrointestinal cancers; targeted therapy; immunotherapy; precision oncology; biomarkers; molecular mechanisms; tumor microenvironment; resistance to therapy; translational research; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Updates in Renal Cell Carcinoma (2nd Edition)

edited by

Irbaz B Riaz

submission deadline 27 Feb 2026 | Viewed by 49 | Submission Open

Keywords: renal cell carcinoma; RCC; machine cearning; clinical; translational developments

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Imaging in Breast Cancer

edited by

Yun-Chung Cheung

Yao Melissa Min-Szu

and Chung Wai-Shan

submission deadline 28 Feb 2026 | 6 articles | Viewed by 12299 | Submission Open

Keywords: breast cancer; mammography/tomosynthesis/contrast-enhanced mammography; sonography/contrast-enhanced sonography; magnetic resonance imaging; PET/CT; quantitative imaging; elastography; optical imaging; artificial intelligence; image-guided biopsy

(This special issue belongs to the Section Methods and Technologies Development)

Challenges and Opportunities for Novel Therapeutic Strategies in Pediatric Oncology

edited by

Jeong A Park

and

Jaume Mora

submission deadline 28 Feb 2026 | 6 articles | Viewed by 10029 | Submission Open

Keywords: antibody-drug conjugate; bispecific antibody; cancer predisposition; CAR T cell; immunotherapy; leukemia; monoclonal antibody; neuroblastoma; pediatric cancer; photoimmunotherapy; precision medicine; sarcoma; translational research; tyrosine kinase inhibitor

(This special issue belongs to the Section Cancer Therapy)

Improving Surgical Care for Patients with Hepatobiliary and Pancreatic Cancers

edited by Christopher B. Nahm and Kai M. Brown

submission deadline 28 Feb 2026 | 2 articles | Viewed by 5987 | Submission Open

Keywords: hepatobiliary; pancreatic; surgery; biomarkers; prognosis; treatment strategy

(This special issue belongs to the Section Cancer Therapy)

Advances in Bladder Preservation Approaches for Bladder Cancer (2nd Edition)

edited by

Jay J. Liao

and Todd A. Yezefski

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5905 | Submission Open

Keywords: bladder cancer; bladder preservation; trimodality therapy; chemoradiation; immunotherapy; intravesical therapy; BCG refractory or unresponsive

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Oncological Imaging (2nd Edition)

edited by

Michaela Cellina

and

Maurizio Cè

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3511 | Submission Open

Keywords: oncological imaging; radiomics; deep learning; machine learning; image reconstruction; artificial intelligence; outcome prediction; oncological treatment planning; advanced imaging; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

Navigating the Landscape of Female Cancers: Recent Discoveries and Treatment Trends

edited by

Federica Martorana

and Giacomo Barchiesi

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2052 | Submission Open

Keywords: female malignancies; breast cancer; gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Therapy)

Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications

edited by

Francois Ducray

, Shawn L. Hervey-Jumper and Thiebaud Picart

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1443 | Submission Open

Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Metastasis)

Cell Therapy in Hematological Malignancies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1367 | Submission Open

Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology

(This special issue belongs to the Section Cancer Therapy)

Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology

edited by Anke Smits and James Dilley

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1361 | Submission Open

Keywords: gynecological cancer; lifestyle; prehabilitation; rehabilitation; survival; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

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