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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights in Parotid Tumors

edited by Chiara Gaudino and Stefan Rohde

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors

(This special issue belongs to the Section Cancer Therapy)

Advances in Genitourinary Cancer: Biomarkers, Immunotherapy and Novel Therapeutics

edited by Lingbin Meng

submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open

Keywords: genitourinary cancer; biomarkers; immunotherapy; targeted therapy; chemotherapy; drug resistance; tumor microenvironment; liquid biopsy; ctDNA; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section “Methods and Technologies Development” in 2025

edited by

Damiano Caruso

and

Marta Zerunian

submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open

Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies

(This special issue belongs to the Section Methods and Technologies Development)

Clinical and Biological Studies of Pediatric Adrenocortical Tumors, Pheochromocytomas and Paragangliomas

edited by

Ronald R. de Krijger

, Verena Wiegering and

Maria Candida Barisson Villares Fragoso

submission deadline 31 Dec 2025 | Viewed by 98 | Submission Open

Keywords: adrenal gland; pheochromocytoma; paraganglioma; adrenocortical adenoma; adrenocortical carcinoma; pediatric; adrenal tumor

(This special issue belongs to the Section Pediatric Oncology)

Contemporary Trends and Advances in Minimally Invasive and Endoscopic Management of Genitourinary Malignancies

edited by

Francesco Del Giudice

submission deadline 31 Dec 2025 | Viewed by 95 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; urologic oncology; prostate cancer; urothelial cancer; kidney cancer; testicular cancer; single-port surgery; image-guided surgery; surgical outcomes; oncologic outcomes; advanced surgical techniques; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Innovations in Microsurgical Techniques for Breast Cancer Reconstruction

edited by

Babak J. Mehrara

and Robert J. Allen

submission deadline 31 Dec 2025 | Viewed by 94 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair

(This special issue belongs to the Section Methods and Technologies Development)

Hippo Signaling in Cancer (2nd Edition)

edited by

Michel Ouellette

and

Ying Yan

submission deadline 31 Dec 2025 | Viewed by 88 | Submission Open

Keywords: Hippo signaling; Salvador– Warts– Hippo (SWH) pathway; YAP/TAZ; cancer development; progression; metastasis; therapeutic resistance

(This special issue belongs to the Section Tumor Microenvironment)

Plasma and Cancer Treatment

edited by

Michael Keidar

and

Vikas Soni

submission deadline 31 Dec 2025 | Viewed by 87 | Submission Open

Keywords: cold atmospheric plasma (CAP); cancer treatment; plasma medicine; reactive oxygen species (ROS); apoptosis; tumor; non-thermal plasma; plasma oncology; cancer and molecular biology; clinical translation; in vivo/preclinical

(This special issue belongs to the Section Cancer Therapy)

Faulty Ribosome Biogenesis and Cancer: Mechanisms and Therapeutic Perspectives

edited by

Paola Bellosta

and

Marianna Penzo

submission deadline 31 Dec 2025 | Viewed by 79 | Submission Open

Keywords: ribosome biogenesis; ribosomal proteins; nucleolar stress; genomic instability; oncoribosome; ribosomapathies; ribosome-targeting drugs; cancer biomarkers; animal models

(This special issue belongs to the Section Cancer Biomarkers)

The Extracellular Matrix and Tissue Engineering: Roles in the Tumor Microenvironment and Implications for Cancer Treatment

edited by

Maria Georgiadou

Eirini Velliou

and

Eugenia Roupakia

submission deadline 31 Dec 2025 | Viewed by 77 | Submission Open

Keywords: extracellular matrix remodeling; stiffness; cancer progression; tumor metastasis; tissue engineering; 3D models; anti-cancer therapies

(This special issue belongs to the Section Cancer Therapy)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Advances in the Molecular Biology of Sarcoma and Drug Development

edited by Francis Hornicek and

Zhenfeng Duan

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

Sarcoma Management in Orthopaedic Oncology

edited by

Vasileios Kontogeorgakos

and Jendrik Hardes

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma

edited by

Kalu U.E. Ogbureke

submission deadline 31 Dec 2025 | Viewed by 60 | Submission Open

Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Minimally Invasive Surgery for Colorectal Cancer

edited by Jonathan S. Abelson and Christine A. Schad

submission deadline 31 Dec 2025 | Viewed by 59 | Submission Open

Keywords: colorectal cancer; minimally invasive surgery; endoscopic surgery; endoluminal surgery; laparoscopic surgery; ro-botic surgery; single incision laparoscopic surgery; postoperative outcomes; survival

(This special issue belongs to the Section Cancer Therapy)

Chromatin-Remodeling Factors in Cancer Cells

edited by

Sudhakar Jha

submission deadline 31 Dec 2025 | Viewed by 50 | Submission Open

Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies

(This special issue belongs to the Section Cancer Pathophysiology)

ALK in Cancer: Lessons from the Future (2nd Edition)

edited by

Petros Christopoulos

and

Richard Bayliss

submission deadline 31 Dec 2025 | Viewed by 48 | Submission Open

Keywords: ALK inhibitors; ALK fusion variants; TP53 mutations; immunotherapy; liquid biopsies; disease monitoring; therapeutic sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 31 Dec 2025 | Viewed by 47 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Advanced Ovarian Cancer (2nd Edition)

edited by

Sheng-Mou Hsiao

submission deadline 31 Dec 2025 | Viewed by 44 | Submission Open

Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Oncogenetics of Colorectal Cancer (2nd Edition)

edited by

Muhammad Kibriya

and Marc Bissonnette

submission deadline 31 Dec 2025 | Viewed by 38 | Submission Open

Keywords: colorectal carcinoma; somatic mutation; microsatellite instability; methylation; copy number change; tumor-infiltrating leukocyte; immune checkpoint inhibitor; drug resistance; cell-free DNA

(This special issue belongs to the Section Cancer Pathophysiology)

Leukemia Cell Signaling Pathways: Recent Advances, Future Perspectives, and Potential Clinical Applications

edited by

Bac Viet Le

and

Srinivas Chatla

submission deadline 31 Dec 2025 | Viewed by 35 | Submission Open

Keywords: leukemia; cell signaling; bone marrow microenvironment; leukemic transformation; drug resistance; therapeutic discovery; cell signaling inhibitors; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2025 | Viewed by 30 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Pituitary Tumors: Clinical and Surgical Challenges

edited by

Michal Hlavac

and

Andrej Pala

submission deadline 31 Dec 2025 | Viewed by 27 | Submission Open

Keywords: pituitary; neuroendocrine tumors; transsphenoidal endoscopic surgery; MRI imaging; quality of life

(This special issue belongs to the Section Clinical Research of Cancer)

Patients’ Perspective in Gynecological Cancer

edited by

Jalid Sehouli

submission deadline 31 Dec 2025 | Viewed by 16 | Submission Open

Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Tumor Microenvironment of Gynecological Tumors

edited by

Zahid Pranjol

and

Dmitry Aleksandrovich Zinovkin

submission deadline 10 Jan 2026 | Viewed by 76 | Submission Open

Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics

(This special issue belongs to the Section Tumor Microenvironment)

The Role of Flow Cytometry in Hematologic Malignancies

edited by

Kristy Wolniak

and Lucy Fu

submission deadline 12 Jan 2026 | Viewed by 26 | Submission Open

Keywords: flow cytometry; hematology; oncology; malignancy; lymphoma; leukemia; pathology; innovation; methodology; diagnosis

(This special issue belongs to the Section Methods and Technologies Development)

Cervical Cancer: Study on Molecular Landscape and Protein Biomarkers. Current Diagnostic and Therapeutic Capabilities

edited by

Christopher Kobierzycki

and

Piotr Dzięgiel

submission deadline 15 Jan 2026 | 5 articles | Viewed by 9230 | Submission Open

Keywords: cervical cancer; cervical dysplasia; human papilloma virus (HPV); tumor markers; cancerogenesis; genotyping

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer

edited by Biniam Kidane

submission deadline 15 Jan 2026 | 5 articles | Viewed by 7331 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs)

edited by Wei Chen, Fei Li and

Qiang Jeremy Wen

submission deadline 15 Jan 2026 | 2 articles | Viewed by 3168 | Submission Open

Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2

(This special issue belongs to the Section Molecular Cancer Biology)

Circulating Tumour DNA and Liquid Biopsy in Oncology

edited by

Yafeng Ma

and Kevin Spring

submission deadline 15 Jan 2026 | 1 articles | Viewed by 548 | Submission Open

Keywords: cell-free DNA; circulating tumour DNA; liquid biopsy; mutation status; tumour mutational burden; methylation detection; fragmentomics; minimal residual disease; early detection

(This special issue belongs to the Section Cancer Biomarkers)

The Survival of Colon and Rectal Cancer (2nd Edition)

edited by

Susanne Merkel

submission deadline 15 Jan 2026 | Viewed by 126 | Submission Open

Keywords: colorectal cancer; colorectal cancer surgery; multidisciplinary treatment; survival; prognostic factors; distant metastasis; locoregional recurrences; standardisation; individualisation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Recent Advances in Liquid Biopsy Biomarkers of Cancer

edited by

Hua-Jun He

submission deadline 15 Jan 2026 | Viewed by 106 | Submission Open

Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; extracellular vesicles; circulating RNA; cfDNA methylation; fragmentome; reference material; miRNA; multi-cancer detection

(This special issue belongs to the Section Cancer Biomarkers)

Updates on Urothelial Carcinoma

edited by

Toyonori Tsuzuki

and Yasmin Abu-Ghanem

submission deadline 15 Jan 2026 | Viewed by 91 | Submission Open

Keywords: urothelial carcinoma; systemic therapy; molecular biomarkers; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Cell Biology of Cancer Invasion: 2nd Edition

edited by

Hideki Yamaguchi

submission deadline 15 Jan 2026 | Viewed by 66 | Submission Open

Keywords: invasion; metastasis; intravasation; extravasation; invadopodia; tumor microenvironment; epithelial– mesenchymal transition; cell migration; cytoskeleton; cell adhesion; extracellular matrix; matrix metalloprotease; cancer-associated fibroblast; tumor-associated macrophage

(This special issue belongs to the Section Cancer Metastasis)

Pediatric Cancer Research from Basic Biology to Experimental Therapy

edited by

Atif Ahmed

submission deadline 16 Jan 2026 | 3 articles | Viewed by 4724 | Submission Open

Keywords: pediatric tumors; solid cancers; leukemias; cancer predisposition syndromes; genetics; omics; immunotherapy; therapy resistance

(This special issue belongs to the Section Pediatric Oncology)

Survivorship Following Childhood, Adolescent and Young Adult Cancer

edited by Magdalena Balcerek and Judith Gebauer

submission deadline 20 Jan 2026 | 1 articles | Viewed by 606 | Submission Open

Keywords: cancer survivorship; late effects; long-term follow-up care; supportive care; health prevention and promotion

(This special issue belongs to the Section Pediatric Oncology)

Cancer Cell Vulnerabilities on Pathways Regulating the Cell Cycle

edited by

Hiroaki Kiyokawa

submission deadline 20 Jan 2026 | Viewed by 219 | Submission Open

Keywords: cell cycle; signaling pathway; precision medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Trends in the Development of Theranostics and Multifunctional Tracers in Oncology

edited by

Olaf Prante

submission deadline 20 Jan 2026 | Viewed by 96 | Submission Open

Keywords: multifunctional radiopharmaceuticls; PET/CT; multimodal imaging; cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

The Prospect of Nanobiotechnology in Cancers

edited by

Wenpan Li

submission deadline 20 Jan 2026 | Viewed by 83 | Submission Open

Keywords: nanobiotechnology; cancer therapy; targeted drug delivery; tumor microenvironment

(This special issue belongs to the Section Methods and Technologies Development)

Recent Updates on Imaging and Staging of Gynecologic Cancers

edited by

David Mutch

and Alexander B. Olawaiye

submission deadline 21 Jan 2026 | 1 articles | Viewed by 1027 | Submission Open

Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis

(This special issue belongs to the Section Methods and Technologies Development)

Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)

edited by

Dario Marchetti

submission deadline 22 Jan 2026 | Viewed by 165 | Submission Open

Keywords: liquid biopsy; CTCs; CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity; clinical validity; and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies

edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and

Boguslaw Mikaszewski

submission deadline 22 Jan 2026 | Viewed by 91 | Submission Open

Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches

(This special issue belongs to the Section Cancer Therapy)

Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition

edited by

Shebli Atrash

submission deadline 23 Jan 2026 | Viewed by 76 | Submission Open

Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | Viewed by 571 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

(This special issue belongs to the Section Cancer Biomarkers)

Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers

edited by

Diego Raimondo

and Gabriele Centini

submission deadline 30 Jan 2026 | 2 articles | Viewed by 8950 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in the Treatment of Upper Gastrointestinal Cancer

edited by Sang-ho Jeong and

Jae-seok Min

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1087 | Submission Open

Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Cancer Disparities: Biological, Social, and Environmental Determinants

edited by

Riffat Mehboob

and

Miguel Muñoz

submission deadline 30 Jan 2026 | 1 articles | Viewed by 125 | Submission Open

Keywords: cancer epidemiology; cancer etiology; environmental factors; screening and diagnostics; SDGs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Metastasis in Tumor Immunity: Current Perspectives

edited by

Ulrike Stein

, Sebastian Torke and

Wolfgang Walther

submission deadline 30 Jan 2026 | Viewed by 100 | Submission Open

Keywords: immune escape; immune evasion; immune microenvironment; intervention strategies; senescence on metastasis; anti-tumor immunity; cellular interactions; molecular interactions; immune suppression; immune checkpoints

(This special issue belongs to the Section Cancer Metastasis)

How COVID-19 Affects Cancer Patients

edited by

Maria Fiore

submission deadline 31 Jan 2026 | 13 articles | Viewed by 20418 | Submission Open

Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Genetics and Epigenetics of Gynecological Cancer

edited by

Carmela De Marco

submission deadline 31 Jan 2026 | 8 articles | Viewed by 18351 | Submission Open

Keywords: gynecologic cancers; epigenetics; genetics; immunogenetics; predisposing mutations; biomarkers; targeted therapies; chemoresistance

(This special issue belongs to the Section Cancer Pathophysiology)

Displaying special issue 751-800 on page 16 of 23.

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