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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Molecular Pathogenesis of T-Cell Lymphoma
edited by
submission deadline 30 Apr 2026 | Viewed by 408 | Submission Open
Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers
(This special issue belongs to the Section Cancer Pathophysiology)
Medical Treatment for Urological Cancers submission deadline 30 Apr 2026 | Viewed by 405 | Submission Open
Keywords: prostate cancer; urothelial cancer; renal cancer; antibody– drug conjugates; cytotoxic chemotherapy; immune checkpoint inhibitors
(This special issue belongs to the Section Cancer Therapy)
Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 387 | Submission Open
Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis
(This special issue belongs to the Section Cancer Therapy)
Advantages and Benefits: Proton Therapy vs. X-Ray Treatment in Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 342 | Submission Open
Keywords: proton therapy; X-ray therapy; foton therapy; in silico dosimetry; in vivo dosimetry; quality assurance; NTCP  models; pediatric cancer patients; vascular biomarkers; hematological biomarkers; hepatic biomarkers; lymphopenia; cardiac toxicity; hepatotoxicity; neurocognition; pneumonitis; long-term sequelae; radiation induced cancer; survival; supportive care; survivors; quality of life; health value; cost 
(This special issue belongs to the Section Cancer Therapy)
The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications
edited by
submission deadline 30 Apr 2026 | Viewed by 313 | Submission Open
Keywords: tumor microenvironment; epigenetics; cancer; immune system; remodeling mechanisms; therapy; clinical application
(This special issue belongs to the Section Tumor Microenvironment)
Targeted Therapies for Pediatric Nervous System Tumors
edited by and Nicole Brossier
submission deadline 30 Apr 2026 | Viewed by 309 | Submission Open
Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma
(This special issue belongs to the Section Pediatric Oncology)
The Latest Advancements in Cutaneous Melanoma
edited by Zhenyu Ji
submission deadline 30 Apr 2026 | 1 articles | Viewed by 267 | Submission Open
Keywords: cutaneous melanoma; skin cancer; immunotherapy; targeted therapy; melanoma biomarkers
(This special issue belongs to the Section Cancer Therapy)
Precision Medicine in Hematological Malignancies: Current Insights and Future Directions
edited by Giuseppe Saglio and Mohamed Yassin
submission deadline 30 Apr 2026 | Viewed by 196 | Submission Open
Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling
(This special issue belongs to the Section Cancer Therapy)
Extracellular Matrix—Role in the Tumor Microenvironment and Impact on Cancer Therapy
edited by Heena Kumra and Makoto Noda
submission deadline 30 Apr 2026 | Viewed by 195 | Submission Open
Keywords: extracellular matrix; stroma; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Cancer Pathophysiology)
New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers
edited by Patriciu Achimas-Cadariu and
submission deadline 30 Apr 2026 | Viewed by 164 | Submission Open
Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers
Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes
edited by and Vittoria Disciglio
submission deadline 30 Apr 2026 | 1 articles | Viewed by 144 | Submission Open
Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant
(This special issue belongs to the Section Cancer Pathophysiology)
Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer submission deadline 30 Apr 2026 | Viewed by 131 | Submission Open
Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming
(This special issue belongs to the Section Tumor Microenvironment)
CT/MRI/PET in Cancer submission deadline 30 Apr 2026 | Viewed by 128 | Submission Open
Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration
(This special issue belongs to the Section Methods and Technologies Development)
The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods
edited by Peter C. Angeletti
submission deadline 30 Apr 2026 | Viewed by 127 | Submission Open
Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host– pathogen interaction
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 122 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open
Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes
(This special issue belongs to the Section Cancer Therapy)
The Changing Paradigms in the Management of Thyroid Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open
Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes
edited by
submission deadline 30 Apr 2026 | Viewed by 108 | Submission Open
Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in the Treatment of Urological Cancer
edited by Anna Patrikidou
submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open
Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics
(This special issue belongs to the Section Cancer Therapy)
Image-Guided Treatment of Liver Tumors
edited by and Niek Wijnen
submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open
Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology
(This special issue belongs to the Section Cancer Therapy)
Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 101 | Submission Open
Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy
(This special issue belongs to the Section Cancer Metastasis)
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers submission deadline 30 Apr 2026 | Viewed by 91 | Submission Open
Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up
(This special issue belongs to the Section Cancer Therapy)
Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open
Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft
(This special issue belongs to the Section Cancer Therapy)
Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours
edited by Crispin T. Hiley and Iain Phillips
submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open
Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR
(This special issue belongs to the Section Cancer Therapy)
Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies
edited by Giuseppe Marulli
submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open
Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery
(This special issue belongs to the Section Cancer Therapy)
PARP Inhibitors in Cancers: 2nd Edition submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open
Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life
edited by , and Juan Carlos Hernández-Rodríguez
submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open
Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Non-Melanoma Skin Cancer: Promises and Challenges submission deadline 30 Apr 2026 | Viewed by 68 | Submission Open
Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique
(This special issue belongs to the Section Cancer Therapy)
EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open
Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer
(This special issue belongs to the Section Cancer Therapy)
Role of Myeloid Cells in the Regulation of Cancer Onset and Development
edited by Rita Campanelli
submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open
Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition) submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open
Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA
(This special issue belongs to the Section Infectious Agents and Cancer)
Next-Generation Boron Neutron Capture Therapy (BNCT) for Cancer Treatment
edited by Dayron Ramos López, Gabriella Pugliese and Raffaella Radogna
submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open
Keywords: BNCT; boron agents; dosimetry; neutron detectors; cancer therapy; imaging; simulation; neutron sources; treatment planning; medical physics
(This special issue belongs to the Section Methods and Technologies Development)
Management of Orbital Tumors
edited by
submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open
Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques
(This special issue belongs to the Section Clinical Research of Cancer)
Clinical Research on the Relationship Between Diet and Cancer Development (2nd Edition)
edited by
submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: diet; nutrition; complementary therapy; vitamins; minerals; micro-nutrients; survival; cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Model for the Development of Anti-Cancer Drugs
edited by
submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open
Keywords: tumor models; preclinical cancer models; organoids and spheroids; patient-derived xenografts (PDX); syngeneic models; 3D bioprinting (tumors); tumor-on-chip; drug development; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Current Concept and Management of Pediatric ATRTs—2nd Edition
edited by and Alicia C. Lenzen
submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open
Keywords: atypical teratoid rhabdoid tumors (ATRTs); CNS tumor; embryonal tumors
(This special issue belongs to the Section Pediatric Oncology)
Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)
edited by and
submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open
Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance
(This special issue belongs to the Section Cancer Therapy)
Research and Clinical Applications of Gynecologic Cancer Detection Technologies
edited by Porfyrios Korompelis
submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open
Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies
(This special issue belongs to the Section Methods and Technologies Development)
Liquid Biopsies in Gynecologic Cancer
edited by , and Ludovica Pepe
submission deadline 30 Apr 2026 | Viewed by 46 | Submission Open
Keywords: liquid biopsy; gynecologic cancer; circulating tumor DNA (ctDNA); ovarian cancer; endometrial cancer; cervical cancer; early detection; personalized medicine; cancer monitoring; non-invasive diagnostics
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology
edited by Evrim Erdemogľu
submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open
Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery
(This special issue belongs to the Section Clinical Research of Cancer)
The Biomarkers of Oral Cancer
edited by
submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Innovative Therapeutics for Breast Cancer: Advancing Clinical Translational Research
edited by
submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open
Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials
(This special issue belongs to the Section Clinical Research of Cancer)
Surgical Treatment and Postoperative Outcomes of Gynecological Cancers
edited by Lauren S. Prescott
submission deadline 30 Apr 2026 | Submission Open
Keywords: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization; surgery; hysterectomy; ovarian cancer; endometrial cancer; cervical cancer
(This special issue belongs to the Section Cancer Therapy)
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 May 2026 | 3 articles | Viewed by 7627 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Cell Adhesion in Human Cancer
edited by , Makoto Osanai and
submission deadline 1 May 2026 | 2 articles | Viewed by 4026 | Submission Open
Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells
(This special issue belongs to the Section Molecular Cancer Biology)
Treatment Response Biomarkers in Hepatocellular Carcinoma: From Basic Science to Clinical Validation
edited by
submission deadline 1 May 2026 | 3 articles | Viewed by 3540 | Submission Open
Keywords: hepatocellular carcinoma; prognostic biomarkers; liver-directed therapy; immune checkpoint inhibitors; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Research Advances and Therapeutic Strategies (RATS) in Cardio-Oncology submission deadline 1 May 2026 | 1 articles | Viewed by 1163 | Submission Open
Keywords: cardiotoxicity; artificial intelligence; multi-omics; cardiac toxicities; surveillance; cardioprotective agents; multimodal imaging
(This special issue belongs to the Section Cancer Therapy)
Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)
edited by Kouji Izumi
submission deadline 1 May 2026 | 1 articles | Viewed by 1088 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent
(This special issue belongs to the Section Cancer Therapy)
Rehabilitation Opportunities in Cancer Survivorship
edited by and Alejandro Heredia-Ciuro
submission deadline 8 May 2026 | 3 articles | Viewed by 4561 | Submission Open
Keywords: cancer; rehabilitation; sequelae; disability; impairment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
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