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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Therapeutic Approaches for Cancer Treatment submission deadline 30 Nov 2025 | 10 articles | Viewed by 15956 | Submission Open
Keywords: cancer; small molecules; epigenetic drugs; drug delivery system; targeted therapy; personalized medicine; photodynamic therapy; photothermal therapy; sonodynamic therapy; drug repurposing; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Radiomics and Imaging in Cancer Analysis submission deadline 30 Nov 2025 | 6 articles | Viewed by 14708 | Submission Open
Keywords: radiomics; biomarker; cancer imaging; machine learning; oncology
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Immunotherapy in Clinical and Translational Research
edited by Sofia Genta
submission deadline 30 Nov 2025 | 6 articles | Viewed by 13830 | Submission Open
Keywords: cancer immunotherapy; clinical research; immune checkpoint inhibitor; cancer vaccines; biomarker; translational research
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Recent Advances in Skin Cancers
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 11979 | Submission Open
Keywords: cutaneous squamous cell carcinoma; staging; surgical treatment; immunotherapy; cemiplimab; adjuvant radiation; gene expression profile; Brigham and Women’ s Hospital tumor staging system; American Joint Committee on Cancer staging system
(This special issue belongs to the Section Cancer Therapy)
Sarcoma: Clinical Trials and Management submission deadline 30 Nov 2025 | 6 articles | Viewed by 7669 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma
(This special issue belongs to the Section Clinical Research of Cancer)
The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 7518 | Submission Open
Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Esophagogastric Cancer
edited by , , Pieter Van der Sluis and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 7328 | Submission Open
Keywords: gastric cancer; esophageal cancer; esophagectomy; chemotherapy; radiotherapy; immunotherapy; perioperative management; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Advancements in Surgical Approaches for Gynecological Cancers submission deadline 30 Nov 2025 | 6 articles | Viewed by 6230 | Submission Open
Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins
(This special issue belongs to the Section Cancer Therapy)
Immune Landscape of Renal Cell Carcinoma
edited by and Yuexin Xu
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4905 | Submission Open
Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor
edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo
submission deadline 30 Nov 2025 | 5 articles | Viewed by 4615 | Submission Open
Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology
(This special issue belongs to the Section Cancer Therapy)
Cell Therapy in Solid Cancers: Current and Future Landscape
edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3942 | Submission Open
Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell
(This special issue belongs to the Section Cancer Therapy)
Novel Advances in Surgery for Prostate Cancer
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3218 | Submission Open
Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3144 | Submission Open
Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome
(This special issue belongs to the Section Cancer Therapy)
Novel Computational Approaches for Molecular Target Discovery in Colorectal Cancer submission deadline 30 Nov 2025 | 1 articles | Viewed by 3081 | Submission Open
Keywords: colorectal cancer; genetics; bioinformatics; therapeutic targets; cancer evolution; personalized medicine; patient stratification; technological advancements; precision oncology; big data; computational approach
(This special issue belongs to the Section Methods and Technologies Development)
Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging
edited by Andra Valentina Krauze
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2907 | Submission Open
Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations
(This special issue belongs to the Section Methods and Technologies Development)
Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis: 2nd Edition
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2439 | Submission Open
Keywords: receptor; tyrosine kinase; growth factor; signal transduction; development regeneration tumorigenesis
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular Pathways in Cancers (2nd Edition) submission deadline 30 Nov 2025 | 1 articles | Viewed by 1455 | Submission Open
Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis
(This special issue belongs to the Section Molecular Cancer Biology)
Tissue-Agnostic Drug Development in Cancer (2nd Edition)
edited by Shivaani Kummar and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1415 | Submission Open
Keywords: tissue-agnostic drug development; pembrolizumab; microsatellite instability-high (MSI-H); tumor mutational burden-high (TMB-H); dostarlimab-gxly; larotrectinib; entrectinib; neurotrophic tyrosine kinase (NTRK)-fusion-positive solid tumors; dabrafenib and trametinib; selpercatinib; rearranged during transfection (RET) gene fusion; precision medicine
(This special issue belongs to the Section Cancer Drug Development)
Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)
edited by Jianguo Tao, Jeffrey W. Craig and Michael E. Williams
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1373 | Submission Open
Keywords: B-cell malignancy; drug resistance; novel therapy; TME; chemoimmunotherapy; targeted agents; immunotherapeutic approaches
(This special issue belongs to the Section Cancer Therapy)
New and Future Focused Therapies for Thyroid Cancer
edited by , Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1361 | Submission Open
Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Advances in Castration-Resistant Prostate Cancer Treatment submission deadline 30 Nov 2025 | 1 articles | Viewed by 1301 | Submission Open
Keywords: androgen receptor; CRPC; chemoresistance; combination therapy; small molecules; chemoprevention; ubiquitination
(This special issue belongs to the Section Cancer Therapy)
Calcium Signaling in Cancer Cell Progression
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 914 | Submission Open
Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in the Surgical Treatment of Spinal Tumors
edited by Daniel Lubelski
submission deadline 30 Nov 2025 | 1 articles | Viewed by 749 | Submission Open
Keywords: spinal tumors; spinal metastases; minimally invasive spine surgery; radiosurgery; histology-specific treatment; prognostic modeling; machine learning; deep learning; spinal reconstruction; quality of life
(This special issue belongs to the Section Cancer Therapy)
Surgery in Metastatic Cancer (2nd Edition) submission deadline 30 Nov 2025 | 1 articles | Viewed by 731 | Submission Open
Keywords: metastatic cancer; surgery; metastasectomy; indication; timing
(This special issue belongs to the Section Cancer Therapy)
The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer
edited by Liliana Streba and Michael Schenker
submission deadline 30 Nov 2025 | 1 articles | Viewed by 580 | Submission Open
Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Microenvironment in Primary Liver Cancer 2nd edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 438 | Submission Open
Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome
(This special issue belongs to the Section Tumor Microenvironment)
Recent Advances in the Molecular Genetics of Sarcomas
edited by Wei Jiang
submission deadline 30 Nov 2025 | Viewed by 420 | Submission Open
Keywords: sarcoma; bone and soft tissue; molecular genetics; molecular pathology; classification
(This special issue belongs to the Section Molecular Cancer Biology)
Surgical Treatment of Abdominal Tumors
edited by and Ioannis Baloyiannis
submission deadline 30 Nov 2025 | Viewed by 379 | Submission Open
Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal
(This special issue belongs to the Section Clinical Research of Cancer)
Mesothelioma: Diagnosis and Therapy
edited by Avinash Aujayeb
submission deadline 30 Nov 2025 | Viewed by 276 | Submission Open
Keywords: malignant pleural mesothelioma; diagnostics; immunotherapy treatment; surgical treatments; intrapleural therapy
(This special issue belongs to the Section Cancer Therapy)
Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions
edited by Yongwoo Dave Seo
submission deadline 30 Nov 2025 | Viewed by 262 | Submission Open
Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design
(This special issue belongs to the Section Cancer Therapy)
Clinical Efficacy of Drug Therapy in Gastrointestinal Cancers submission deadline 30 Nov 2025 | Viewed by 226 | Submission Open
Keywords: classical chemotherapy; targeted therapeutics; immunotherapy; adjuvant therapy; neoadjuvant therapy; induction therapy; multidisciplinary treatments; gastric cancer; colorectal cancer
(This special issue belongs to the Section Clinical Research of Cancer)
Epigenetics in Cancer and Drug Therapeutics
edited by Bethsebie Sailo and Anup R. Sharma
submission deadline 30 Nov 2025 | Viewed by 219 | Submission Open
Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Non-Coding RNAs and Extracellular Vesicles in Cancer Crosstalk: Diagnostic and Therapeutic Implications 2nd Edition submission deadline 30 Nov 2025 | Viewed by 212 | Submission Open
Keywords: extracellular vesicles; exosomes; cancer; inflammation; non-coding RNA; microRNAs; circular-RNAs; PIWI-RNAs; lnc-RNAs
(This special issue belongs to the Section Cancer Therapy)
Disparities in Thoracic Oncology Patients
edited by Jeffrey B. Velotta and
submission deadline 30 Nov 2025 | Viewed by 207 | Submission Open
Keywords: lung cancer; disparities; thoracic oncology
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Targeted Therapies in Cancer (2nd Edition)
edited by
submission deadline 30 Nov 2025 | Viewed by 172 | Submission Open
Keywords: targeted therapy; cancer; antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy
(This special issue belongs to the Section Cancer Therapy)
New Approaches in Modulating Transcription Factors for Cancer Therapy 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 171 | Submission Open
Keywords: transcription factors; cancer treatment; degraders; inhibitors
(This special issue belongs to the Section Cancer Therapy)
New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice
edited by Xiaotong Song
submission deadline 30 Nov 2025 | Viewed by 161 | Submission Open
Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)
edited by Cesare Guida and Ida D'Onofrio
submission deadline 30 Nov 2025 | Viewed by 156 | Submission Open
Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers
(This special issue belongs to the Section Cancer Therapy)
Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition) submission deadline 30 Nov 2025 | Viewed by 145 | Submission Open
Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical and Surgical Therapy for Colorectal Cancer
edited by Laura Koskenvuo
submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open
Keywords: colorectal cancer; rectal cancer; anterior resection; minimally invasive surgery; robotic surgery; surgical oncology; neoadjuvant therapy; adjuvant therapy; quality of life; gut microbiome
(This special issue belongs to the Section Cancer Therapy)
Epstein-Barr Virus-Associated Cancers: From Pathogenesis to Treatment (2nd Edition)
edited by
submission deadline 30 Nov 2025 | Viewed by 124 | Submission Open
Keywords: EBV; lymphomas; Burkitt lymphoma; Hodgkin lymphoma; NK/T cell lymphoma; nasopharyngeal carcinoma; gastric cancer; biomarkers; immunotherapy; targeted therapy
(This special issue belongs to the Section Infectious Agents and Cancer)
Image Analysis and Machine Learning in Cancers: 2nd Edition submission deadline 30 Nov 2025 | Viewed by 113 | Submission Open
Keywords: cancer detection and diagnosis system; machine learning; deep learning; medical imaging analysis; few-shot deep learning; attention segmentation; feature extraction; probabilistic models; explainability; image fusion; generative adversarial network
(This special issue belongs to the Section Methods and Technologies Development)
PET/CT in Radiation Oncology
edited by Gurdip Azad and
submission deadline 30 Nov 2025 | Viewed by 113 | Submission Open
Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Integrin Beta-1 Signaling in Cancers
edited by Adama Sidibé and Bernhard Wehrle-Haller
submission deadline 30 Nov 2025 | Viewed by 103 | Submission Open
Keywords: integrin beta-1; cancer cell; tissue stroma; fibrosis; talin-1; paxillin; kinases; acetyltransferases; FAK; SRC kinase; SFK; cell proliferation; adhesion; migration; drug resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Nanoparticle and Exosome Technology for Delivery of Payloads in CNS Tumors
edited by
submission deadline 30 Nov 2025 | Viewed by 67 | Submission Open
Keywords: glioblastoma; brain metastasis; nanoparticles; exosomes; viral therapy; delivery of payload; imaging probes
(This special issue belongs to the Section Cancer Drug Development)
In Vitro and In Vivo Pharmacology for Glioma Drug Discovery submission deadline 30 Nov 2025 | Viewed by 61 | Submission Open
Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence
(This special issue belongs to the Section Cancer Drug Development)
Gastrointestinal and Its Associated Malignancies: Diagnosis, Targets and Therapies
edited by Ganji P. Nagaraju and
submission deadline 1 Dec 2025 | 3 articles | Viewed by 4242 | Submission Open
Keywords: GI cancers; oncogenesis; diagnosis; target identification; biomarkers; therapy
(This special issue belongs to the Section Cancer Therapy)
Post-transcriptional Regulation of Cancer-Related Processes
edited by
submission deadline 1 Dec 2025 | 1 articles | Viewed by 2658 | Submission Open
Keywords: microRNAs; long-non-coding RNA; RNA-binding proteins; stress granules; P-bodies
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Studies in Gastrointestinal Malignancies submission deadline 1 Dec 2025 | 3 articles | Viewed by 2285 | Submission Open
Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology submission deadline 5 Dec 2025 | 4 articles | Viewed by 9493 | Submission Open
Keywords: tumor microenvironment; natural food extracts; molecular markers; abscopal effect; RT technology; prognosis; side effects and abscopal effects
(This special issue belongs to the Section Tumor Microenvironment)
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