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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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CAR T-Cell Therapy and Multiple Myeloma
edited by Jo Caers
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1047 | Submission Open
Keywords: multiple myeloma; CAR-T immunotherapy; toxicity; efficacy; tumor models; safety
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Advances and Approaches in Thyroid Cancer
edited by and José Manuel Rodríguez
submission deadline 31 Aug 2026 | 1 articles | Viewed by 856 | Submission Open
Keywords: thyroid cancer; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; poorly differentiated thyroid tumours; novel approaches; prognostic biomarkers; risk stratification
(This special issue belongs to the Section Cancer Therapy)
Emergencies in Gastrointestinal Surgical Oncology submission deadline 31 Aug 2026 | Viewed by 575 | Submission Open
Keywords: surgical oncology; emergencies; emergency surgery; acute care surgery; palliation; futility in surgery
(This special issue belongs to the Section Clinical Research of Cancer)
Hereditary Cancer: State of the Art
edited by Joanne Ngeow, Jianbang Chiang and
submission deadline 31 Aug 2026 | Viewed by 216 | Submission Open
Keywords: hereditary cancer syndromes; inherited cancers; cancer genetics and genomics; germline variants; surveillance
(This special issue belongs to the Section Cancer Pathophysiology)
Hypoxia-Targeting Strategies to Improve Cancer Therapy Outcomes
edited by Roben Gieling and Ayse Latif
submission deadline 31 Aug 2026 | 1 articles | Viewed by 179 | Submission Open
Keywords: tumor hypoxia; cancer therapy resistance; hypoxia-targeted therapy; hypoxia-inducible factors (HIFs); hypoxia-activated prodrugs; oxygen-modifying agents; combination therapy; precision drug delivery; tumor microenvironment; translational cancer research
(This special issue belongs to the Section Cancer Therapy)
CAR T Cell Therapy in Cancer: Progress and Challenges Across Solid and Hematologic Malignancies
edited by John F. Marshall and Lauren C. Cutmore
submission deadline 31 Aug 2026 | Viewed by 134 | Submission Open
Keywords: CAR-T cell therapy; adoptive cell therapy; immunotherapy; antigen escape; solid tumor; hematologic malignancies
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Acute Myeloid Leukemia in Adults (2nd Edition) submission deadline 31 Aug 2026 | Viewed by 126 | Submission Open
Keywords: acute myeloid leukemia; molecular biology; treatment landscape; resistance mechanisms
(This special issue belongs to the Section Clinical Research of Cancer)
Human Carcinogens—Chemical Agents, Occupational Exposure and Health Impact
edited by Jun-Pyo Myong
submission deadline 31 Aug 2026 | Viewed by 122 | Submission Open
Keywords: occupational exposure; chemical carcinogens; risk assessment; epidemiology; biomarkers; exposure assessment; preventive strategies; workplace safety; occupational health; regulatory measures
(This special issue belongs to the Section Infectious Agents and Cancer)
Clinical Treatment and Outcomes of Gastrointestinal Cancer
edited by Mary Linton Peters
submission deadline 31 Aug 2026 | Viewed by 121 | Submission Open
Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation
(This special issue belongs to the Section Clinical Research of Cancer)
The Unseen Burden: Incidence and Outcomes of Infections in Leukemia submission deadline 31 Aug 2026 | Viewed by 99 | Submission Open
Keywords: infection management; infectious risk; antimicrobial therapy; antimicrobial prophylaxis
(This special issue belongs to the Section Infectious Agents and Cancer)
Advances in the Multimodal Management of Pancreatic Ductal Adenocarcinoma submission deadline 31 Aug 2026 | Viewed by 98 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); multimodal approach; systemic therapy; radiotherapy; targeted strategies; neoadjuvant therapy; adjuvant therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in the Early Diagnosis and Treatment of Gastric Cancer (2nd Edition)
edited by Sharona B. Ross
submission deadline 31 Aug 2026 | Viewed by 96 | Submission Open
Keywords: gastric cancer; tumor resection; liver tumors
(This special issue belongs to the Section Cancer Therapy)
Early Detection and Strategies for Overcoming Therapy Resistance in Lung Cancer and Mesothelioma
edited by
submission deadline 31 Aug 2026 | Viewed by 81 | Submission Open
Keywords: lung cancer; mesothelioma; screening; biomarker; molecular diagnostics; resistance
(This special issue belongs to the Section Cancer Therapy)
Wnt Signaling Pathway in Cancer Immunotherapy
edited by and
submission deadline 31 Aug 2026 | Viewed by 73 | Submission Open
Keywords: Wnt signaling; immunotherapy; immune cells; macrophages; T-cell; CART cells; stromal cells; tumor microenvireonment; cancers; cancer stem cells
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
mTOR Signaling in Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 72 | Submission Open
Keywords: mTOR; cancer; cell signaling; pathway addiction; tumor metabolism; glycolysis; autophagy; apoptosis; rapamycin
(This special issue belongs to the Section Molecular Cancer Biology)
Advancements in Brain Cancer Research: From Molecular Mechanisms to Translational Therapeutic Strategies submission deadline 31 Aug 2026 | Viewed by 63 | Submission Open
Keywords: brain cancer; glioblastoma; tumor microenvironment; cancer stem cells; molecular therapeutics; epigenetic regulation; nanomedicine; translational oncology; therapeutic resistance
Clinical Trials for T-Cell Lymphoma
edited by Jasmine M. Zain
submission deadline 31 Aug 2026 | Viewed by 45 | Submission Open
Keywords: peripheral T cell lymphoma; EZH2 inhibitors; JAK STAT  pathways; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Cytoskeleton in Tumor Growth and Progression
edited by David Gau
submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open
Keywords: actin cytoskeleton; microtubules; mechano-transduction; tumor microenvironment; angiogenesis; mitochondria
(This special issue belongs to the Section Molecular Cancer Biology)
The Role of Artificial Intelligence in Detection and Treatment of Head and Neck Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; large language models; multimodal integration; computer vision; pathomics; image-derived biomarkers
(This special issue belongs to the Section Methods and Technologies Development)
Discovery and Development of New Anticancer Drugs and Delivery Systems: Special Emphasis on Artificial Intelligence, Machine-Learning, and Big Data Analysis submission deadline 31 Aug 2026 | Viewed by 36 | Submission Open
Keywords: artificial intelligence; machine learning; big-data analytics; natural compounds; translational oncology; drug delivery systems
(This special issue belongs to the Section Cancer Drug Development)
Applications of Computed Tomography in Lung Cancer
edited by Yukinori Sakao
submission deadline 31 Aug 2026 | Viewed by 28 | Submission Open
Keywords: lung cancer; computed tomography (CT); radiomics; artificial intelligence (AI); image-guided surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cancer Therapy-Related Adverse Events (2nd Edition)
edited by and Pauline Funchain
submission deadline 1 Sep 2026 | 2 articles | Viewed by 6436 | Submission Open
Keywords: cancer; cancer therapy; toxicities; adverse events
(This special issue belongs to the Section Cancer Therapy)
The Role of Minimally Invasive and Minimally Radical Surgery in Cervical and Endometrial Cancer
edited by , , Christophe Pomel, and Gwénaël Ferron
submission deadline 1 Sep 2026 | 1 articles | Viewed by 446 | Submission Open
Keywords: cervical cancer; endometrial cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; fertility-sparing surgery; non-radical surgery; conservative surgery
(This special issue belongs to the Section Cancer Therapy)
Prostatectomy Today: Surgical Advances in Prostate Cancer Management
edited by
submission deadline 1 Sep 2026 | Viewed by 92 | Submission Open
Keywords: prostate cancer; robot-assisted radical prostatectomy; robotic system; perioperative outcomes; sexual function; urinary continence; oncological outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Exercise and Cancer Treatment: The Clinical Application of Exercise Oncology
edited by and Geovana Leite
submission deadline 10 Sep 2026 | 3 articles | Viewed by 1782 | Submission Open
Keywords: exercise oncology; cancer therapy; immunotherapy; patient outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Interventional Oncologic Therapies
edited by Edward W. Lee and
submission deadline 15 Sep 2026 | 3 articles | Viewed by 11544 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
First-Line Therapy in Thoracic Oncology
edited by Antonio D'Andrilli and
submission deadline 15 Sep 2026 | 4 articles | Viewed by 4451 | Submission Open
Keywords: thoracic oncology; lung cancer; thymoma; mediastinal tumors
(This special issue belongs to the Section Cancer Therapy)
The Clinical, Technological, and Scientific Progress of Boron Neutron Capture Therapy
edited by
submission deadline 15 Sep 2026 | Viewed by 836 | Submission Open
Keywords: boron neutron capture therapy (BNCT); neutron capture therapy (NCT); accelerator-based neutron source; neutron dosimetry; boron drug development; alternative capture agents; radiobiological effects; radiation oncology; interdisciplinary research; clinical translation
(This special issue belongs to the Section Cancer Therapy)
Evidence-Based Care for Managing Oncologic Emergencies in Patients with Cancer submission deadline 15 Sep 2026 | Viewed by 119 | Submission Open
Keywords: oncologic emergencies; cancer; urgent; infections; adverse events; thrombosis; febrile neutropenia; pain; spinal cord compression; goals of care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
New Models of Cancer Care to Improve Patient Experiences and Clinical Outcomes
edited by
submission deadline 15 Sep 2026 | Viewed by 119 | Submission Open
Keywords: patient-centered care; community-based interventions; innovative care models; digital health solutions; patient engagement; clinical outcomes; value-based cancer care
Breast Cancer: Immune Response, Immune Microenvironment, and Immunotherapy submission deadline 15 Sep 2026 | Viewed by 105 | Submission Open
Keywords: breast cancer; immune response; tumor immune microenvironment; immunotherapy resistance; intrinsic and extrinsic mechanisms; immune checkpoint inhibitors; T-cell dysfunction; cytokines; cancer vaccines; tumor immunosuppression
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Breast Conservation Therapy: A Global Perspective
edited by Tristen S. Park
submission deadline 15 Sep 2026 | Viewed by 60 | Submission Open
Keywords: breast conservation therapy; survival; breast cancer
(This special issue belongs to the Section Cancer Therapy)
Advances in Endoscopy for Early Detection and Precision Diagnosis of Gastrointestinal Cancers
edited by Ishaan Vohra
submission deadline 15 Sep 2026 | Viewed by 9 | Submission Open
Keywords: endoscopy; gastrointestinal cancer; early detection; artificial intelligence; advanced imaging; molecular diagnostics; precision medicine; biomarkers; screening; surveillance
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
T Cells in Hematologic Malignancies: Biology, Microenvironment, and Therapeutic Advances submission deadline 16 Sep 2026 | Viewed by 134 | Submission Open
Keywords: T cells; hematologic malignancies; CAR-T therapy; bispecific T cell engagers; tumor immune microenvironment; T cell dysfunction and exhaustion; leukemia; lymphoma; and myeloma; acute myeloid leukemia and MDS; immunotherapy resistance and relapse; next-generation cellular therapies
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Management of Pancreatic Cancer: 2nd Edition
edited by
submission deadline 18 Sep 2026 | Viewed by 97 | Submission Open
Keywords: pancreatic cancer; adenocarcinoma; neuroendocrine carcinomas; molecular and pathological aspects; diagnosis; medical treatment; palliative therapy
Advances in Salivary Gland Carcinoma: 2nd Edition
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 7265 | Submission Open
Keywords: salivary gland tumors; head and neck cancer; facial nerve preservation; facial nerve reconstruction; facial nerve sacrifice; parotid cancer; parotidectomy; prognostic factors
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Molecular Pathology Insights in Thyroid Cancer
edited by Salma Khan
submission deadline 20 Sep 2026 | Viewed by 306 | Submission Open
Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Clinical Outcomes in Upper GI Cancers
edited by
submission deadline 20 Sep 2026 | Viewed by 137 | Submission Open
Keywords: esophageal cancer; gastric cancer; esophagogastric junction cancer; surgery; endoscopy; chemotherapy; immuno-therapy; molecural target therapy; biomarker
(This special issue belongs to the Section Clinical Research of Cancer)
Targeting the Vulnerabilities of Oncogene Activation (Second Edition)
edited by
submission deadline 25 Sep 2026 | Viewed by 275 | Submission Open
Keywords: tumorigenesis; tumor-suppressor genes; oncogene; target
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Bone Metastasis Research: From Mechanisms to Therapy
edited by Ye Lin
submission deadline 25 Sep 2026 | Viewed by 61 | Submission Open
Keywords: bone metastasis; tumour microenvironment; biomarker; targeted therapy; detection; palliative care
(This special issue belongs to the Section Cancer Metastasis)
Role of Iron Metabolism in Tumor Progression
edited by
submission deadline 25 Sep 2026 | Viewed by 60 | Submission Open
Keywords: iron metabolism; ferroptosis; tumor microenvironment; oxidative stress; iron chelation therapy; ferritin; transferrin receptor; cancer metabolism; redox homeostasis; therapeutic targeting
(This special issue belongs to the Section Molecular Cancer Biology)
Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (2nd Edition) submission deadline 30 Sep 2026 | 7 articles | Viewed by 15320 | Submission Open
Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Decision-Making Biomarkers in the Treatment of Hepatocellular Carcinoma
edited by and
submission deadline 30 Sep 2026 | 5 articles | Viewed by 5855 | Submission Open
Keywords: hepatocellular carcinoma; borderline resectable; conversion therapy; neoadjuvant therapy; immunotherapy; immune-related adverse event; molecular-targeted agent
(This special issue belongs to the Section Cancer Biomarkers)
Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-Axial Brain Tumors
edited by , Carlo Giussani, Cesare Zoia and Daniele Bongetta
submission deadline 30 Sep 2026 | 2 articles | Viewed by 5618 | Submission Open
Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Microenvironment Dynamics in Hepatocellular Carcinoma
edited by Joseph Franses and Adam Burgoyne
submission deadline 30 Sep 2026 | 3 articles | Viewed by 3750 | Submission Open
Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions
(This special issue belongs to the Section Tumor Microenvironment)
Novel Advancements in Prostate Cancer Surgery: Indications and Techniques
edited by Valerio Santarelli and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1621 | Submission Open
Keywords: radical prostatectomy; prostate cancer; technology; minimally invasive surgery
(This special issue belongs to the Section Cancer Therapy)
Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management
edited by and Stefan Haider
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1582 | Submission Open
Keywords: machine learning; radiomics; cancer imaging; malignancy; survival
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)
edited by and Ida D'Onofrio
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1162 | Submission Open
Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers
(This special issue belongs to the Section Cancer Therapy)
Advances in Brain Tumors
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 692 | Submission Open
Keywords: diagnosis; biomarker; treatment; brain tumors
(This special issue belongs to the Section Clinical Research of Cancer)
Targeting RNA to Improve Cancer Precision Medicine
edited by , Anna Grimaldi and Chiara Tammaro
submission deadline 30 Sep 2026 | Viewed by 543 | Submission Open
Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine
(This special issue belongs to the Section Cancer Therapy)
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