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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Treatment and Outcomes of Gastrointestinal Cancer
edited by Mary Linton Peters
submission deadline 31 Aug 2026 | Viewed by 119 | Submission Open
Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation
(This special issue belongs to the Section Clinical Research of Cancer)
The Unseen Burden: Incidence and Outcomes of Infections in Leukemia submission deadline 31 Aug 2026 | Viewed by 99 | Submission Open
Keywords: infection management; infectious risk; antimicrobial therapy; antimicrobial prophylaxis
(This special issue belongs to the Section Infectious Agents and Cancer)
Advances in the Multimodal Management of Pancreatic Ductal Adenocarcinoma submission deadline 31 Aug 2026 | Viewed by 97 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); multimodal approach; systemic therapy; radiotherapy; targeted strategies; neoadjuvant therapy; adjuvant therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in the Early Diagnosis and Treatment of Gastric Cancer (2nd Edition)
edited by Sharona B. Ross
submission deadline 31 Aug 2026 | Viewed by 93 | Submission Open
Keywords: gastric cancer; tumor resection; liver tumors
(This special issue belongs to the Section Cancer Therapy)
Early Detection and Strategies for Overcoming Therapy Resistance in Lung Cancer and Mesothelioma
edited by
submission deadline 31 Aug 2026 | Viewed by 81 | Submission Open
Keywords: lung cancer; mesothelioma; screening; biomarker; molecular diagnostics; resistance
(This special issue belongs to the Section Cancer Therapy)
Wnt Signaling Pathway in Cancer Immunotherapy
edited by and
submission deadline 31 Aug 2026 | Viewed by 73 | Submission Open
Keywords: Wnt signaling; immunotherapy; immune cells; macrophages; T-cell; CART cells; stromal cells; tumor microenvireonment; cancers; cancer stem cells
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
mTOR Signaling in Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 72 | Submission Open
Keywords: mTOR; cancer; cell signaling; pathway addiction; tumor metabolism; glycolysis; autophagy; apoptosis; rapamycin
(This special issue belongs to the Section Molecular Cancer Biology)
Advancements in Brain Cancer Research: From Molecular Mechanisms to Translational Therapeutic Strategies submission deadline 31 Aug 2026 | Viewed by 62 | Submission Open
Keywords: brain cancer; glioblastoma; tumor microenvironment; cancer stem cells; molecular therapeutics; epigenetic regulation; nanomedicine; translational oncology; therapeutic resistance
Clinical Trials for T-Cell Lymphoma
edited by Jasmine M. Zain
submission deadline 31 Aug 2026 | Viewed by 42 | Submission Open
Keywords: peripheral T cell lymphoma; EZH2 inhibitors; JAK STAT  pathways; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
The Role of Artificial Intelligence in Detection and Treatment of Head and Neck Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; large language models; multimodal integration; computer vision; pathomics; image-derived biomarkers
(This special issue belongs to the Section Methods and Technologies Development)
Cytoskeleton in Tumor Growth and Progression
edited by David Gau
submission deadline 31 Aug 2026 | Viewed by 37 | Submission Open
Keywords: actin cytoskeleton; microtubules; mechano-transduction; tumor microenvironment; angiogenesis; mitochondria
(This special issue belongs to the Section Molecular Cancer Biology)
Discovery and Development of New Anticancer Drugs and Delivery Systems: Special Emphasis on Artificial Intelligence, Machine-Learning, and Big Data Analysis submission deadline 31 Aug 2026 | Viewed by 32 | Submission Open
Keywords: artificial intelligence; machine learning; big-data analytics; natural compounds; translational oncology; drug delivery systems
(This special issue belongs to the Section Cancer Drug Development)
Applications of Computed Tomography in Lung Cancer
edited by Yukinori Sakao
submission deadline 31 Aug 2026 | Viewed by 25 | Submission Open
Keywords: lung cancer; computed tomography (CT); radiomics; artificial intelligence (AI); image-guided surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Cancer Therapy-Related Adverse Events (2nd Edition)
edited by and Pauline Funchain
submission deadline 1 Sep 2026 | 2 articles | Viewed by 6388 | Submission Open
Keywords: cancer; cancer therapy; toxicities; adverse events
(This special issue belongs to the Section Cancer Therapy)
The Role of Minimally Invasive and Minimally Radical Surgery in Cervical and Endometrial Cancer
edited by , , Christophe Pomel, and Gwénaël Ferron
submission deadline 1 Sep 2026 | 1 articles | Viewed by 438 | Submission Open
Keywords: cervical cancer; endometrial cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; fertility-sparing surgery; non-radical surgery; conservative surgery
(This special issue belongs to the Section Cancer Therapy)
Prostatectomy Today: Surgical Advances in Prostate Cancer Management
edited by
submission deadline 1 Sep 2026 | Viewed by 89 | Submission Open
Keywords: prostate cancer; robot-assisted radical prostatectomy; robotic system; perioperative outcomes; sexual function; urinary continence; oncological outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Exercise and Cancer Treatment: The Clinical Application of Exercise Oncology
edited by and Geovana Leite
submission deadline 10 Sep 2026 | 2 articles | Viewed by 1755 | Submission Open
Keywords: exercise oncology; cancer therapy; immunotherapy; patient outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Interventional Oncologic Therapies
edited by Edward W. Lee and
submission deadline 15 Sep 2026 | 3 articles | Viewed by 11503 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
First-Line Therapy in Thoracic Oncology
edited by Antonio D'Andrilli and
submission deadline 15 Sep 2026 | 4 articles | Viewed by 4414 | Submission Open
Keywords: thoracic oncology; lung cancer; thymoma; mediastinal tumors
(This special issue belongs to the Section Cancer Therapy)
The Clinical, Technological, and Scientific Progress of Boron Neutron Capture Therapy
edited by
submission deadline 15 Sep 2026 | Viewed by 835 | Submission Open
Keywords: boron neutron capture therapy (BNCT); neutron capture therapy (NCT); accelerator-based neutron source; neutron dosimetry; boron drug development; alternative capture agents; radiobiological effects; radiation oncology; interdisciplinary research; clinical translation
(This special issue belongs to the Section Cancer Therapy)
Evidence-Based Care for Managing Oncologic Emergencies in Patients with Cancer submission deadline 15 Sep 2026 | Viewed by 117 | Submission Open
Keywords: oncologic emergencies; cancer; urgent; infections; adverse events; thrombosis; febrile neutropenia; pain; spinal cord compression; goals of care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
New Models of Cancer Care to Improve Patient Experiences and Clinical Outcomes
edited by
submission deadline 15 Sep 2026 | Viewed by 117 | Submission Open
Keywords: patient-centered care; community-based interventions; innovative care models; digital health solutions; patient engagement; clinical outcomes; value-based cancer care
Breast Cancer: Immune Response, Immune Microenvironment, and Immunotherapy submission deadline 15 Sep 2026 | Viewed by 103 | Submission Open
Keywords: breast cancer; immune response; tumor immune microenvironment; immunotherapy resistance; intrinsic and extrinsic mechanisms; immune checkpoint inhibitors; T-cell dysfunction; cytokines; cancer vaccines; tumor immunosuppression
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Breast Conservation Therapy: A Global Perspective
edited by Tristen S. Park
submission deadline 15 Sep 2026 | Viewed by 58 | Submission Open
Keywords: breast conservation therapy; survival; breast cancer
(This special issue belongs to the Section Cancer Therapy)
Advances in Endoscopy for Early Detection and Precision Diagnosis of Gastrointestinal Cancers
edited by Ishaan Vohra
submission deadline 15 Sep 2026 | Submission Open
Keywords: endoscopy; gastrointestinal cancer; early detection; artificial intelligence; advanced imaging; molecular diagnostics; precision medicine; biomarkers; screening; surveillance
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
T Cells in Hematologic Malignancies: Biology, Microenvironment, and Therapeutic Advances submission deadline 16 Sep 2026 | Viewed by 130 | Submission Open
Keywords: T cells; hematologic malignancies; CAR-T therapy; bispecific T cell engagers; tumor immune microenvironment; T cell dysfunction and exhaustion; leukemia; lymphoma; and myeloma; acute myeloid leukemia and MDS; immunotherapy resistance and relapse; next-generation cellular therapies
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Management of Pancreatic Cancer: 2nd Edition
edited by
submission deadline 18 Sep 2026 | Viewed by 92 | Submission Open
Keywords: pancreatic cancer; adenocarcinoma; neuroendocrine carcinomas; molecular and pathological aspects; diagnosis; medical treatment; palliative therapy
Advances in Salivary Gland Carcinoma: 2nd Edition
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 7219 | Submission Open
Keywords: salivary gland tumors; head and neck cancer; facial nerve preservation; facial nerve reconstruction; facial nerve sacrifice; parotid cancer; parotidectomy; prognostic factors
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Molecular Pathology Insights in Thyroid Cancer
edited by Salma Khan
submission deadline 20 Sep 2026 | Viewed by 304 | Submission Open
Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance
(This special issue belongs to the Section Cancer Pathophysiology)
Clinical Outcomes in Upper GI Cancers
edited by
submission deadline 20 Sep 2026 | Viewed by 134 | Submission Open
Keywords: esophageal cancer; gastric cancer; esophagogastric junction cancer; surgery; endoscopy; chemotherapy; immuno-therapy; molecural target therapy; biomarker
(This special issue belongs to the Section Clinical Research of Cancer)
Targeting the Vulnerabilities of Oncogene Activation (Second Edition)
edited by
submission deadline 25 Sep 2026 | Viewed by 274 | Submission Open
Keywords: tumorigenesis; tumor-suppressor genes; oncogene; target
(This special issue belongs to the Section Methods and Technologies Development)
Role of Iron Metabolism in Tumor Progression
edited by
submission deadline 25 Sep 2026 | Viewed by 60 | Submission Open
Keywords: iron metabolism; ferroptosis; tumor microenvironment; oxidative stress; iron chelation therapy; ferritin; transferrin receptor; cancer metabolism; redox homeostasis; therapeutic targeting
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Bone Metastasis Research: From Mechanisms to Therapy
edited by Ye Lin
submission deadline 25 Sep 2026 | Viewed by 60 | Submission Open
Keywords: bone metastasis; tumour microenvironment; biomarker; targeted therapy; detection; palliative care
(This special issue belongs to the Section Cancer Metastasis)
Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (2nd Edition) submission deadline 30 Sep 2026 | 7 articles | Viewed by 15250 | Submission Open
Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Decision-Making Biomarkers in the Treatment of Hepatocellular Carcinoma
edited by and
submission deadline 30 Sep 2026 | 5 articles | Viewed by 5784 | Submission Open
Keywords: hepatocellular carcinoma; borderline resectable; conversion therapy; neoadjuvant therapy; immunotherapy; immune-related adverse event; molecular-targeted agent
(This special issue belongs to the Section Cancer Biomarkers)
Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-Axial Brain Tumors
edited by , Carlo Giussani, Cesare Zoia and Daniele Bongetta
submission deadline 30 Sep 2026 | 2 articles | Viewed by 5562 | Submission Open
Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Microenvironment Dynamics in Hepatocellular Carcinoma
edited by Joseph Franses and Adam Burgoyne
submission deadline 30 Sep 2026 | 3 articles | Viewed by 3699 | Submission Open
Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions
(This special issue belongs to the Section Tumor Microenvironment)
Novel Advancements in Prostate Cancer Surgery: Indications and Techniques
edited by Valerio Santarelli and
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1612 | Submission Open
Keywords: radical prostatectomy; prostate cancer; technology; minimally invasive surgery
(This special issue belongs to the Section Cancer Therapy)
Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management
edited by and Stefan Haider
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1525 | Submission Open
Keywords: machine learning; radiomics; cancer imaging; malignancy; survival
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)
edited by and Ida D'Onofrio
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1160 | Submission Open
Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers
(This special issue belongs to the Section Cancer Therapy)
Advances in Brain Tumors
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 660 | Submission Open
Keywords: diagnosis; biomarker; treatment; brain tumors
(This special issue belongs to the Section Clinical Research of Cancer)
Targeting RNA to Improve Cancer Precision Medicine
edited by , Anna Grimaldi and Chiara Tammaro
submission deadline 30 Sep 2026 | Viewed by 540 | Submission Open
Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives submission deadline 30 Sep 2026 | 1 articles | Viewed by 317 | Submission Open
Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship
(This special issue belongs to the Section Clinical Research of Cancer)
Artificial Intelligence (AI), Robotics, and Cancer Surgery
edited by Zaid M. Abdelsattar
submission deadline 30 Sep 2026 | Viewed by 262 | Submission Open
Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging
edited by
submission deadline 30 Sep 2026 | Viewed by 198 | Submission Open
Keywords: immune-related adverse events (irAEs); accelerated aging; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Cancer Drug Resistance: Mechanisms and Overcoming Strategies
edited by
submission deadline 30 Sep 2026 | Viewed by 151 | Submission Open
Keywords: intrinsic resistance; acquired resistance; targeted therapy resistance; combination treatment strategies; immunotherapy resistance; tumor heterogeneity
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications
edited by
submission deadline 30 Sep 2026 | Viewed by 141 | Submission Open
Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma
(This special issue belongs to the Section Tumor Microenvironment)
Pediatric Surgery in Oncology: Innovations, Challenges, and Future Directions
edited by Abdelhafeez H. Abdelhafeez and Kokila Lakhoo
submission deadline 30 Sep 2026 | Viewed by 139 | Submission Open
Keywords: pediatric surgical oncology; intraoperative image guidance; minimally invasive surgery; fluorescence guidance; augmented reality; precision cancer surgery
(This special issue belongs to the Section Pediatric Oncology)
The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)
edited by and Kanae Taruno
submission deadline 30 Sep 2026 | 1 articles | Viewed by 135 | Submission Open
Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level
(This special issue belongs to the Section Tumor Microenvironment)
Medical Image-Based Cervical Cancer Prevention, Diagnosis, and Treatment
edited by Emma R. Allanson and Ming Yin Lin
submission deadline 30 Sep 2026 | Viewed by 124 | Submission Open
Keywords: medical imaging; 3-dimensional imaging; cervical cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
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