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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Immune Microenvironment in Gastric Cancers

edited by

Chandrani Sarkar

and

Debanjan Chakroborty

submission deadline 25 Dec 2025 | 4 articles | Viewed by 17882 | Submission Open

Keywords: tumor immune microenvironment; gastric cancer; therapeutic strategies; therapeutic response; tumor-associated macrophages

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Ovarian Cancer Research and Treatment: 2nd Edition

edited by

Maria Barbolina

submission deadline 25 Dec 2025 | 4 articles | Viewed by 7551 | Submission Open

Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets

(This special issue belongs to the Section Cancer Therapy)

Epigenetics in Endocrine-Related Cancer

edited by Jennie N Jeyapalan

submission deadline 25 Dec 2025 | 2 articles | Viewed by 4727 | Submission Open

Keywords: breast; ovarian; CRPC (castration-resistant prostate cancer); thyroid; histone modification; DNA methylation; epigenomics; chromatin; microRNAs; lncRNAs; epi-drugs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Measurable Residual Disease in Cancer: 2nd Edition

edited by Krzysztof Jamroziak and

Bartosz Pula

submission deadline 25 Dec 2025 | Viewed by 238 | Submission Open

Keywords: MRD; measurable residual disease; minimal residual disease; cancer; tumor microenvironment; next generation sequencing; flow cytometry; imaging techniques

(This special issue belongs to the Section Cancer Drug Development)

Predictive Biomarkers for Lung Cancer

edited by Ole Hilberg

submission deadline 30 Dec 2025 | 10 articles | Viewed by 27518 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

Class 2 Tumor Suppressor Gene Pathways for Therapeutic Applications in Hard-to-Treat Cancers

edited by

Edgar Dahl

submission deadline 30 Dec 2025 | 2 articles | Viewed by 6218 | Submission Open

Keywords: hard-to-treat cancers; HTT cancers; class 2 tumor suppressor genes; C2TSGs; DNA methylation driver; DNAme driver; epigenetic therapies; cancer drug development; personalized cancer therapy; tumor suppressor mimetics

(This special issue belongs to the Section Tumor Microenvironment)

Understanding the Complexities of Anticancer Drugs Resistance

edited by

Mariarosaria Conte

and

Nunzio Del Gaudio

submission deadline 30 Dec 2025 | 2 articles | Viewed by 5218 | Submission Open

(This special issue belongs to the Section Cancer Drug Development)

Transcription Factors in Breast Cancer

edited by

Sarah Walker

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4404 | Submission Open

Keywords: breast cancer; transcription factors; signaling pathways; hormone receptors; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Surgical Treatment Approaches in Advanced Gastrointestinal Neoplasms

edited by Francesco Santullo and Agostino Maria De Rose

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3632 | Submission Open

Keywords: advanced gastrointestinal neoplasms; colon cancer; cytoreductive surgery; gastric cancer; liver metastases; peritoneal metastases; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy); pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Combination Therapy in Geriatric Population with Cancer (2nd Edition)

edited by

Lore Decoster

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2634 | Submission Open

Keywords: older patients with cancer; surgery; radiotherapy; chemotherapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials for Thoracic Cancers

edited by

Monica Casiraghi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 806 | Submission Open

Keywords: lung cancer; thoracic oncology; thymoma; mesothelioma

(This special issue belongs to the Section Clinical Research of Cancer)

Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer

edited by

Subburaj Ilangumaran

and

Seung-Hwan Lee

submission deadline 30 Dec 2025 | Viewed by 633 | Submission Open

Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity

(This special issue belongs to the Section Molecular Cancer Biology)

Insights from the Editorial Board Member

edited by

Carlos S. Moreno

submission deadline 31 Dec 2025 | 53 articles | Viewed by 140700 | Submission Open

Keywords: cancer therapeutics; cancer biomarkers; precision medicine; cancer genomics; cancer immunology; cancer biology; clinical trials; cancer epidemiology and prevention; tumor microenvironment and metastasis; cancer informatics

Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management

edited by

Roberto Fabiani

and

Irene Giacchetta

submission deadline 31 Dec 2025 | 19 articles | Viewed by 52882 | Submission Open

Keywords: non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); prevention; risk management; mechanisms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Integrating Palliative Care in Oncology

edited by

Albert Tuca-Rodríguez

submission deadline 31 Dec 2025 | 13 articles | Viewed by 39413 | Submission Open

Keywords: early palliative care; advanced cancer; complexity of care needs; integration of palliative care in oncology; cancer pain; symptom control; end-of-life; advance care planning

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Skin Cancer: Diagnosis, Treatment and Prognosis

edited by Iris Zalaudek and

Roberta Giuffrida

submission deadline 31 Dec 2025 | 14 articles | Viewed by 38239 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Cervical Cancer: Screening and Treatment in 2024-2025

edited by

Fabrice Lécuru

and

Benedetta Guani

submission deadline 31 Dec 2025 | 9 articles | Viewed by 37769 | Submission Open

Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Disparities in Cancer Prevention, Screening, Diagnosis and Management

edited by

Eliza W. Beal

submission deadline 31 Dec 2025 | 17 articles | Viewed by 37651 | Submission Open

Keywords: social determinants of health (SDOH); financial toxicity; racial disparities; ethnic disparities; LGBTQIA+ disparities; cultural competency; cancer; health status disparities; healthcare disparities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advanced Diagnostics and Optical Imaging Technologies in Cancer Research

edited by Vlad Mihai Voiculescu

submission deadline 31 Dec 2025 | 12 articles | Viewed by 28384 | Submission Open

Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies

(This special issue belongs to the Section Methods and Technologies Development)

PTEN: Regulation, Signalling and Targeting in Cancer

edited by

Mark G.H. Scott

Larissa Kotelevets

and

Éric Chastre

submission deadline 31 Dec 2025 | 7 articles | Viewed by 26902 | Submission Open

Keywords: PTEN; tumour suppressor; phosphatase; AKT signalling; genome integrity; apoptosis; proliferation; cancer; biomarker; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Oral Potentially Malignant Disorders and Oral Cavity Cancer

edited by

I-Ta Lee

submission deadline 31 Dec 2025 | 9 articles | Viewed by 25888 | Submission Open

Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine

(This special issue belongs to the Section Cancer Therapy)

Oncology: State-of-the-Art Research and Initiatives in Japan

edited by

Satoshi Ikeda

and

Tateaki Naito

submission deadline 31 Dec 2025 | 8 articles | Viewed by 23505 | Submission Open

Keywords: Japan; cancer; oncology; research; clinical trial; survivorship; patient support

Medical Imaging and Artificial Intelligence in Cancer

edited by Debiao Li and

Stephen J. Pandol

submission deadline 31 Dec 2025 | 11 articles | Viewed by 23101 | Submission Open

Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Biology, Diagnosis and Management of Cervical Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

, Thomas Vrekoussis and

George Valasoulis

submission deadline 31 Dec 2025 | 6 articles | Viewed by 16621 | Submission Open

Keywords: cervical cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Updates in Neuroendocrine Neoplasms

edited by Jonathan Strosberg

submission deadline 31 Dec 2025 | 9 articles | Viewed by 16503 | Submission Open

Keywords: neuroendocrine tumors; neuroendocrine neoplasms; neuroendocrine carcinomas; therapy; germline mutations; somatic mutations

(This special issue belongs to the Section Cancer Therapy)

The Advance of Biomarker-Driven Targeted Therapies in Cancer

edited by

Tianshun Zhang

, Qiushi Wang and Ann Bode

submission deadline 31 Dec 2025 | 5 articles | Viewed by 15488 | Submission Open

Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy

(This special issue belongs to the Section Cancer Therapy)

Long-Term Cancer Survivors: Rehabilitation and Quality of Life

edited by

Juan Rodríguez-Mansilla

Blanca Gonzalez-Sanchez

and

María Jiménez-Palomares

submission deadline 31 Dec 2025 | 7 articles | Viewed by 15301 | Submission Open

Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Chronic Lymphocytic Leukaemia (CLL) Research

edited by

H. Denis Alexander

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14931 | Submission Open

Keywords: chronic lymphocytic leukaemia; CLL; aetiology; oncogenic transformation; survival; cure

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section "Tumor Microenvironment"

edited by

Sanjay Gupta

submission deadline 31 Dec 2025 | 6 articles | Viewed by 14645 | Submission Open

Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response

(This special issue belongs to the Section Tumor Microenvironment)

State-of-the-Art Treatment on Chemotherapy and Immunotherapy for Urological Cancer

edited by

Kouji Izumi

and Hiroshi Yaegashi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 13786 | Submission Open

Keywords: chemotherapy; immunotherapy; antibody– drug conjugate; radioligand therapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; urachal cancer; penile cancer; adrenal cancer; sarcoma; clinical trial; basic research

(This special issue belongs to the Section Tumor Microenvironment)

Robotic Surgery in Colorectal Cancer

edited by James Chi Yong Ngu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 13652 | Submission Open

Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy

(This special issue belongs to the Section Clinical Research of Cancer)

Advancements in Preclinical Models for Solid Cancers

edited by

Ewa Krawczyk

and Paula Dobosz

submission deadline 31 Dec 2025 | 6 articles | Viewed by 13510 | Submission Open

Keywords: solid cancers; preclinical cancer models; in vitro cancer models; in vivo cancer models; translational cancer research; strengths and limitations of preclinical cancer models

(This special issue belongs to the Section Clinical Research of Cancer)

The Applications of Artificial Intelligence in Gastroenterology

edited by

Marcello F. Maida

Ciro Celsa

and Louis H. S. Lau

submission deadline 31 Dec 2025 | 3 articles | Viewed by 12685 | Submission Open

Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases

(This special issue belongs to the Section Cancer Therapy)

Surgery for Colorectal Cancer

edited by

Antonio V. Sterpetti

and

Raimondo Gabriele

submission deadline 31 Dec 2025 | 7 articles | Viewed by 12615 | Submission Open

Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer

(This special issue belongs to the Section Cancer Therapy)

Physiotherapy in Advanced Cancer and Palliative Care

edited by Nele Adriaenssens

submission deadline 31 Dec 2025 | 3 articles | Viewed by 12548 | Submission Open

Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Lymph Node Dissection for Gynecologic Cancers

edited by

Fabio Landoni

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11995 | Submission Open

(This special issue belongs to the Section Methods and Technologies Development)

Medical Complications and Supportive Care in Patients with Cancer (2nd Edition)

edited by

Javier Marco-Hernández

submission deadline 31 Dec 2025 | 10 articles | Viewed by 11773 | Submission Open

Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Unravelling Cancer Mechanism and Developing Novel Therapeutics: An Urgent Need to Treat Cancer (2nd Edition)

edited by

Santosh Kumar Singh

and

Rajesh Singh

submission deadline 31 Dec 2025 | 6 articles | Viewed by 11080 | Submission Open

Keywords: cancer; anticancer therapy; combination therapy; natural compound; nanotherapy; exosome therapy; targeted therapy; immunotherapy; chemokines; cytokines; antibodies; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition

edited by

Andrew Stephens

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10555 | Submission Open

Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion

(This special issue belongs to the Section Cancer Biomarkers)

Radiomics in Cancer

edited by Isabelle M. Germano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10486 | Submission Open

Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care

(This special issue belongs to the Section Cancer Therapy)

Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets

edited by

Annapina Russo

Giulia Russo

and

Annalisa Pecoraro

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10447 | Submission Open

Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction

(This special issue belongs to the Section Cancer Biomarkers)

The Development and Application of Imaging Biomarkers in Cancer

edited by

Abhishek Mahajan

submission deadline 31 Dec 2025 | 5 articles | Viewed by 9884 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Technological Development for Advances in Cancer Research and Precision Oncology

edited by

Nelson Yee

Ilias Georgakopoulos-Soares

and Fenglong Ma

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9530 | Submission Open

Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics

(This special issue belongs to the Section Molecular Cancer Biology)

Immunotherapy in Non-Small Cell Lung Cancers

edited by Marco Russano

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9174 | Submission Open

Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advancements in Head and Neck Cancer Surgery

edited by

Carlos M. Chiesa-Estomba

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8327 | Submission Open

Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging

(This special issue belongs to the Section Clinical Research of Cancer)

Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics

edited by

Athanasios G. Papavassiliou

and

Le Zhang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8212 | Submission Open

Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications

(This special issue belongs to the Section Cancer Therapy)

Ovarian Cancer Stem Cells and Tumor Microenvironment

edited by

Carrie House

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8136 | Submission Open

Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts

(This special issue belongs to the Section Tumor Microenvironment)

Cost-Effectiveness Studies in Cancers

edited by

Ippazio Cosimo Antonazzo

Paolo Angelo Cortesi

and

Pietro Ferrara

submission deadline 31 Dec 2025 | 5 articles | Viewed by 7957 | Submission Open

Keywords: cancer therapies; cost-effectiveness; cost-utility; cost-consequence; treatment economic impact; health economic; economic sustainability; public health; decision analytical models.

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Pancreatic Ductal Adenocarcinoma Diagnosis and Treatment 2nd Edition

edited by

Andrzej Deptała

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7936 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; genetic changes; genomics; surgical resection; radiotherapy; radiochemotherapy; chemotherapy; targeted therapy; immunotherapy; resectable tumor; borderline resectable tumor; metastatic disease; nutritional treatment; quality of life

(This special issue belongs to the Section Cancer Therapy)

AI-Based Applications in Cancers

edited by

Xia Jiang

submission deadline 31 Dec 2025 | 9 articles | Viewed by 7902 | Submission Open

Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer

(This special issue belongs to the Section Cancer Informatics and Big Data)

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