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Cancers 2018, 10(5), 148; https://doi.org/10.3390/cancers10050148

p53-Autophagy-Metastasis Link

1
Faculty of Medicine, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia
2
Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Received: 23 April 2018 / Revised: 8 May 2018 / Accepted: 16 May 2018 / Published: 18 May 2018
(This article belongs to the Special Issue p53 Signaling in Cancers)
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Abstract

The tumor suppressor p53 as the “guardian of the genome” plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence suggests that this function of p53 is closely involved in the process of cancer development. Here, present knowledge concerning a p53-autophagy-metastasis link, as well as therapeutic approaches that influence this link, are discussed. View Full-Text
Keywords: autophagy; apoptosis; p53; cancer; metastasis autophagy; apoptosis; p53; cancer; metastasis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Denisenko, T.V.; Pivnyuk, A.D.; Zhivotovsky, B. p53-Autophagy-Metastasis Link. Cancers 2018, 10, 148.

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