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p53 and the Viral Connection: Back into the Future

Department of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Box 19, 74100 Ness-Ziona, Israel
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
This review is dedicated to the 25th memorial year of Prof. Yosef Aloni of the Weizmann Institute of Science, for his seminal and important pioneering research in the field of molecular biology of the SV40 virus.
Cancers 2018, 10(6), 178;
Received: 15 May 2018 / Revised: 31 May 2018 / Accepted: 1 June 2018 / Published: 4 June 2018
(This article belongs to the Special Issue p53 Signaling in Cancers)
The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Viruses have learned to manipulate WTp53 through different strategies to improve their replication and spreading in a stage-specific, bidirectional way. While some viruses require active WTp53 for efficient viral replication, others require reduction/inhibition of WTp53 activity. A better understanding of WTp53 functionality in viral life may offer new future clinical approaches, based on WTp53 manipulation, for viral infections. View Full-Text
Keywords: virus; p53; cancer; SV40; papilloma; zika; influenza; HIV-1; HSV-1; vaccinia virus; p53; cancer; SV40; papilloma; zika; influenza; HIV-1; HSV-1; vaccinia
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Aloni-Grinstein, R.; Charni-Natan, M.; Solomon, H.; Rotter, V. p53 and the Viral Connection: Back into the Future . Cancers 2018, 10, 178.

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