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The Role of JMY in p53 Regulation

Nuffield Division of Clinical Laboratory Science—Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 DU, UK
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Cancers 2018, 10(6), 173; https://doi.org/10.3390/cancers10060173
Received: 13 April 2018 / Revised: 10 May 2018 / Accepted: 10 May 2018 / Published: 31 May 2018
(This article belongs to the Special Issue p53 Signaling in Cancers)
Following the event of DNA damage, the level of tumour suppressor protein p53 increases inducing either cell cycle arrest or apoptosis. Junctional Mediating and Regulating Y protein (JMY) is a transcription co-factor involved in p53 regulation. In event of DNA damage, JMY levels also upregulate in the nucleus where JMY forms a co-activator complex with p300/CREB-binding protein (p300/CBP), Apoptosis-stimulating protein of p53 (ASPP) and Stress responsive activator of p53 (Strap). This co-activator complex then binds to and increases the ability of p53 to induce transcription of proteins triggering apoptosis but not cell cycle arrest. This then suggests that the increase of JMY levels due to DNA damage putatively “directs” p53 activity toward triggering apoptosis. JMY expression is also linked to increased cell motility as it: (1) downregulates the expression of adhesion molecules of the Cadherin family and (2) induces actin nucleation, making cells less adhesive and more mobile, favouring metastasis. All these characteristics taken together imply that JMY possesses both tumour suppressive and tumour metastasis promoting capabilities. View Full-Text
Keywords: p53; JMY; regulation; apoptosis; motility p53; JMY; regulation; apoptosis; motility
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MDPI and ACS Style

Adighibe, O.; Pezzella, F. The Role of JMY in p53 Regulation. Cancers 2018, 10, 173. https://doi.org/10.3390/cancers10060173

AMA Style

Adighibe O, Pezzella F. The Role of JMY in p53 Regulation. Cancers. 2018; 10(6):173. https://doi.org/10.3390/cancers10060173

Chicago/Turabian Style

Adighibe, Omanma, and Francesco Pezzella. 2018. "The Role of JMY in p53 Regulation" Cancers 10, no. 6: 173. https://doi.org/10.3390/cancers10060173

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