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AZD1775 Increases Sensitivity to Olaparib and Gemcitabine in Cancer Cells with p53 Mutations

40 Years of Research Put p53 in Translation

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France
Author to whom correspondence should be addressed.
Cancers 2018, 10(5), 152;
Received: 18 April 2018 / Revised: 15 May 2018 / Accepted: 18 May 2018 / Published: 21 May 2018
(This article belongs to the Special Issue p53 Signaling in Cancers)
Since its discovery in 1979, p53 has shown multiple facets. Initially the tumor suppressor p53 protein was considered as a stress sensor able to maintain the genome integrity by regulating transcription of genes involved in cell cycle arrest, apoptosis and DNA repair. However, it rapidly came into light that p53 regulates gene expression to control a wider range of biological processes allowing rapid cell adaptation to environmental context. Among them, those related to cancer have been extensively documented. In addition to its role as transcription factor, scattered studies reported that p53 regulates miRNA processing, modulates protein activity by direct interaction or exhibits RNA-binding activity, thus suggesting a role of p53 in regulating several layers of gene expression not restricted to transcription. After 40 years of research, it appears more and more clearly that p53 is strongly implicated in translational regulation as well as in the control of the production and activity of the translational machinery. Translation control of specific mRNAs could provide yet unsuspected capabilities to this well-known guardian of the genome. View Full-Text
Keywords: p53; translational control; ribosome; cancer p53; translational control; ribosome; cancer
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MDPI and ACS Style

Marcel, V.; Nguyen Van Long, F.; Diaz, J.-J. 40 Years of Research Put p53 in Translation. Cancers 2018, 10, 152.

AMA Style

Marcel V, Nguyen Van Long F, Diaz J-J. 40 Years of Research Put p53 in Translation. Cancers. 2018; 10(5):152.

Chicago/Turabian Style

Marcel, Virginie, Flora Nguyen Van Long, and Jean-Jacques Diaz. 2018. "40 Years of Research Put p53 in Translation" Cancers 10, no. 5: 152.

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