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Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression

Department of Molecular Oncology, Institute for Advanced Medical Sciences, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan
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Cancers 2018, 10(7), 219; https://doi.org/10.3390/cancers10070219
Received: 18 May 2018 / Revised: 18 June 2018 / Accepted: 22 June 2018 / Published: 27 June 2018
(This article belongs to the Special Issue p53 Signaling in Cancers)
p53 has functional roles in tumor suppression as a guardian of the genome, surveillant of oncogenic cell transformation, and as recently demonstrated, a regulator of intracellular metabolism. Accumulating evidence has shown that the tumor microenvironment, accompanied by inflammation and tissue remodeling, is important for cancer proliferation, metastasis, and maintenance of cancer stem cells (CSCs) that self-renew and generate the diverse cells comprising the tumor. Furthermore, p53 has been demonstrated to inhibit inflammatory responses, and functional loss of p53 causes excessive inflammatory reactions. Moreover, the generation and maintenance of CSCs are supported by the inflammatory tumor microenvironment. Considering that the functions of p53 inhibit reprogramming of somatic cells to stem cells, p53 may have a major role in the inflammatory microenvironment as a tumor suppressor. Here, we review our current understanding of the mechanisms underlying the roles of p53 in regulation of the inflammatory microenvironment, tumor microenvironment, and tumor suppression. View Full-Text
Keywords: p53; inflammation; tumor microenvironment; cancer stem cells; nuclear factor-κB (NF-κB); cancer metabolism; oxidative stress; cellular reprograming p53; inflammation; tumor microenvironment; cancer stem cells; nuclear factor-κB (NF-κB); cancer metabolism; oxidative stress; cellular reprograming
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MDPI and ACS Style

Uehara, I.; Tanaka, N. Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression. Cancers 2018, 10, 219. https://doi.org/10.3390/cancers10070219

AMA Style

Uehara I, Tanaka N. Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression. Cancers. 2018; 10(7):219. https://doi.org/10.3390/cancers10070219

Chicago/Turabian Style

Uehara, Ikuno, and Nobuyuki Tanaka. 2018. "Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression" Cancers 10, no. 7: 219. https://doi.org/10.3390/cancers10070219

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