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Regulators of Oncogenic Mutant TP53 Gain of Function

1
Department of Cancer Biology, The University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS 66010, USA
2
Department of Hematology and Oncology, Children’s Mercy Research Institute, Kansas City, MO 64108, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(1), 4; https://doi.org/10.3390/cancers11010004
Received: 15 November 2018 / Revised: 11 December 2018 / Accepted: 18 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue p53 Signaling in Cancers)
The tumor suppressor p53 (TP53) is the most frequently mutated human gene. Mutations in TP53 not only disrupt its tumor suppressor function, but also endow oncogenic gain-of-function (GOF) activities in a manner independent of wild-type TP53 (wtp53). Mutant TP53 (mutp53) GOF is mainly mediated by its binding with other tumor suppressive or oncogenic proteins. Increasing evidence indicates that stabilization of mutp53 is crucial for its GOF activity. However, little is known about factors that alter mutp53 stability and its oncogenic GOF activities. In this review article, we primarily summarize key regulators of mutp53 stability/activities, including genotoxic stress, post-translational modifications, ubiquitin ligases, and molecular chaperones, as well as a single nucleotide polymorphism (SNP) and dimer-forming mutations in mutp53. View Full-Text
Keywords: TP53; mutant TP53; gain of function; post-translational modification; molecular chaperone; single nucleotide polymorphism; dimer-forming mutation TP53; mutant TP53; gain of function; post-translational modification; molecular chaperone; single nucleotide polymorphism; dimer-forming mutation
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MDPI and ACS Style

Yamamoto, S.; Iwakuma, T. Regulators of Oncogenic Mutant TP53 Gain of Function. Cancers 2019, 11, 4. https://doi.org/10.3390/cancers11010004

AMA Style

Yamamoto S, Iwakuma T. Regulators of Oncogenic Mutant TP53 Gain of Function. Cancers. 2019; 11(1):4. https://doi.org/10.3390/cancers11010004

Chicago/Turabian Style

Yamamoto, Satomi; Iwakuma, Tomoo. 2019. "Regulators of Oncogenic Mutant TP53 Gain of Function" Cancers 11, no. 1: 4. https://doi.org/10.3390/cancers11010004

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