Thyroid Cancer

Dear Colleagues,

The incidence of thyroid cancer has dramatically increased in the last 40 years, due to both an improved detection of small (<2 cm) thyroid nodules by neck ultrasonography and a true escalation in thyroid cancer incidence. In spite of this dramatic increase, the vast majority (more than 85%) of thyroid cancer patients are cured by initial treatment and mortality is stably low. This claims for the need of precise parameters able to distinguish between indolent and clinically aggressive nodules, to avoid overtreatment and to accurately identify those tumors that require a more aggressive therapy. Molecular biology has been of great benefit in this respect, and new classifications, taking into account molecular parameters, have recently been introduced, defining new subclasses of thyroid tumors.  The aim of this Special Issue is to provide an overview of recent developments in understanding the biology and molecular oncology of thyroid tumors of follicular cell derivation and their repercussions on the diagnosis, prognosis and therapy. 

We particularly welcome contributions on all aspects related to thyroid tumors of follicular origin, in the form of either original research articles, concise reviews, or shorter perspective articles. Articles with mechanistic and functional insights from a cellular and molecular biological perspective are especially welcome. 

Relevant topics include, but are not limited to:

• Molecular pathology of follicular cell derived thyroid cancer
• Preoperative evaluation of thyroid nodules: ultrasonography     
• Preoperative evaluation of thyroid nodules: cytopathology      
• Thyroid tumors in children    
• Radiation-induced thyroid cancer
• The role of Chemokines in Thyroid Cancer Microenvironment      
• The role of miRNA and long non coding RNA in thyroid cancer      
• The role of precision thyroid cancer medicine
• Thyroid cancer stem and progenitor cells
• Radioiodine-refractory thyroid cancer
• Tyrosine kinase inhibitors
• Immunotherapy for thyroid carcinoma
• Thyroid cancer proteomics
• Thyroid cancer metabolomics

Prof. Roberta Vanni
Prof. Giovanni Tallini
Prof. Efisio Puxeddu
Guest Editors

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