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Open AccessArticle

MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules

1
Center of Biostatistics for Clinical Epidemiology, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Vedano al Lambro, Italy
2
Proteomics and Metabolomics platform, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Vedano al Lambro, Italy
3
Department of radiology, San Gerardo Hospital, 20900 ASST Monza, Italy
4
Department of Endocrinology, San Gerardo Hospital, 20900 ASST Monza, Italy
5
Department of Surgery, San Gerardo Hospital, 20900 ASST Monza, Italy
6
Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, 20900 ASST Monza, Italy
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this manuscript.
Cancers 2019, 11(9), 1377; https://doi.org/10.3390/cancers11091377
Received: 6 September 2019 / Revised: 12 September 2019 / Accepted: 13 September 2019 / Published: 16 September 2019
(This article belongs to the Special Issue Thyroid Cancer)
The present study applies for the first time as Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging (MSI) on real thyroid Fine Needle Aspirations (FNAs) to test its possible complementary role in routine cytology in the diagnosis of thyroid nodules. The primary aim is to evaluate the potential employment of MALDI-MSI in cytopathology, using challenging samples such as needle washes. Firstly, we designed a statistical model based on the analysis of Regions of Interest (ROIs), according to the morphological triage performed by the pathologist. Successively, the capability of the model to predict the classification of the FNAs was validated in a different group of patients on ROI and pixel-by-pixel approach. Results are very promising and highlight the possibility to introduce MALDI-MSI as a complementary tool for the diagnostic characterization of thyroid nodules. View Full-Text
Keywords: thyroid carcinoma; MALDI-MSI; proteomics; Fine Needle Aspiration thyroid carcinoma; MALDI-MSI; proteomics; Fine Needle Aspiration
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MDPI and ACS Style

Capitoli, G.; Piga, I.; Galimberti, S.; Leni, D.; Pincelli, A.I.; Garancini, M.; Clerici, F.; Mahajneh, A.; Brambilla, V.; Smith, A.; Magni, F.; Pagni, F. MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules. Cancers 2019, 11, 1377.

AMA Style

Capitoli G, Piga I, Galimberti S, Leni D, Pincelli AI, Garancini M, Clerici F, Mahajneh A, Brambilla V, Smith A, Magni F, Pagni F. MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules. Cancers. 2019; 11(9):1377.

Chicago/Turabian Style

Capitoli, Giulia; Piga, Isabella; Galimberti, Stefania; Leni, Davide; Pincelli, Angela I.; Garancini, Mattia; Clerici, Francesca; Mahajneh, Allia; Brambilla, Virginia; Smith, Andrew; Magni, Fulvio; Pagni, Fabio. 2019. "MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules" Cancers 11, no. 9: 1377.

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