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Open AccessArticle

Epidemiology of Simultaneous Medullary and Papillary Thyroid Carcinomas (MTC/PTC): An Italian Multicenter Study

by Marialuisa Appetecchia 1,*, Rosa Lauretta 1, Agnese Barnabei 1, Letizia Pieruzzi 2, Irene Terrenato 3, Elisabetta Cavedon 4, Caterina Mian 4, Maria Grazia Castagna 5 and Rossella Elisei 2,† on behalf of the SIE (Italian Society of Endocrinology) Working Group
1
Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy
2
Endocrinology Unit, University Hospital of Pisa, 56121 Pisa, Italy
3
Biostatistics-Scientific Direction, IRCSS Regina Elena National Institute, 00144 Rome, Italy
4
Istituto Oncologico Veneto, University of Padua, 35100 Padua, Italy
5
Endocrinology Unit, Policlinico S.M. alle Scotte, 53100 Siena, Italy
*
Author to whom correspondence should be addressed.
Listed in Appendix A.
Cancers 2019, 11(10), 1516; https://doi.org/10.3390/cancers11101516
Received: 11 September 2019 / Accepted: 25 September 2019 / Published: 9 October 2019
(This article belongs to the Special Issue Thyroid Cancer)
Background: The concomitant presence of papillary thyroid cancer (PTC) and medullary TC (MTC) is rare. In this multicentric study, we documented the epidemiological characteristics, disease conditions and clinical outcome of patients with simultaneous MTC/PTC. Methods: We collected data of patients with concomitant MTC/PTC at 14 Italian referral centers. Results: In total, 183 patients were enrolled. Diagnosis was mostly based on cytological examination (n = 58, 32%). At diagnosis, in the majority of cases, both PTC (n = 142, 78%) and MTC (n = 100, 54%) were at stage I. However, more cases of stage II–IV were reported with MTC (stage IV: n = 27, 15%) compared with PTC (n = 9, 5%). Information on survival was available for 165 patients: 109 patients (66%) were disease-free for both PTC and MTC at the last follow-up. Six patients died from MTC. Median time to progression was 123 months (95% confidence interval (CI): 89.3–156.7 months). Overall, 45% of patients were disease-free after >10 years from diagnosis (125 months); this figure was 72.5% for PTC and 51.1% for MTC. Conclusions: When MTC and PTC are concurrent, the priority should be given to the management of MTC since this entity appears associated with the most severe impact on prognosis. View Full-Text
Keywords: medullary thyroid cancer; papillary thyroid cancer; epidemiology medullary thyroid cancer; papillary thyroid cancer; epidemiology
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Appetecchia, M.; Lauretta, R.; Barnabei, A.; Pieruzzi, L.; Terrenato, I.; Cavedon, E.; Mian, C.; Castagna, M.G.; Elisei, R., on behalf of the SIE (Italian Society of Endocrinology) Working Group; Epidemiology of Simultaneous Medullary and Papillary Thyroid Carcinomas (MTC/PTC): An Italian Multicenter Study. Cancers 2019, 11, 1516.

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