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Epidemiology of Simultaneous Medullary and Papillary Thyroid Carcinomas (MTC/PTC): An Italian Multicenter Study
Open AccessReview

Virotherapy as a Potential Therapeutic Approach for the Treatment of Aggressive Thyroid Cancer

Dipartimento di Scienze Mediche Traslazionali, Università Federico II Napoli, URT “Genomic of Diabetes” of Institute of Experimental Endocrinology and Oncology “G. Salvatore”, National Council of Research (CNR), 80131 Naples, Italy
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Cancers 2019, 11(10), 1532; https://doi.org/10.3390/cancers11101532
Received: 18 September 2019 / Revised: 2 October 2019 / Accepted: 3 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Thyroid Cancer)
Virotherapy is a novel cancer treatment based on oncolytic viruses (OVs), which selectively infect and lyse cancer cells, without harming normal cells or tissues. Several viruses, either naturally occurring or developed through genetic engineering, are currently under investigation in clinical studies. Emerging reports suggesting the immune-stimulatory property of OVs against tumor cells further support the clinical use of OVs for the treatment of lesions lacking effective therapies. Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC), have a poor prognosis and limited treatment options. Therefore, several groups investigated the therapeutic potential of OVs in PDTC/ATC models producing experimental data sustaining the potential clinical efficacy of OVs in these cancer models. Moreover, the presence of an immunosuppressive microenvironment further supports the potential use of OVs in ATC. In this review, we present the results of the studies evaluating the efficacy of OVs alone or in combination with other treatment options. In particular, their potential therapeutic combination with multiple kinases inhibitors (MKIs) or immune checkpoint inhibitors are discussed.
Keywords: oncolytic virus; immunotherapy; anaplastic and poorly differentiated thyroid carcinoma oncolytic virus; immunotherapy; anaplastic and poorly differentiated thyroid carcinoma
MDPI and ACS Style

Malfitano, A.M.; Somma, S.D.; Prevete, N.; Portella, G. Virotherapy as a Potential Therapeutic Approach for the Treatment of Aggressive Thyroid Cancer. Cancers 2019, 11, 1532.

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