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Critical Prognostic Parameters in the Anatomic Pathology Reporting of Differentiated Follicular Cell-Derived Thyroid Carcinoma

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
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Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1100; https://doi.org/10.3390/cancers11081100
Received: 17 July 2019 / Revised: 30 July 2019 / Accepted: 31 July 2019 / Published: 2 August 2019
(This article belongs to the Special Issue Thyroid Cancer)
In the past decades, pathology reporting on thyroid carcinoma has evolved from a narrative approach to structured synoptic reports. Many histologic variables are present in the current synoptic reports that are crucial elements for initial risk stratification and clinical management. In this review, we compare and summarize the key prognostic pathologic characteristics utilized by the most influential clinical and pathologic guidelines from the American Thyroid Association (ATA), the National Comprehensive Cancer Network (NCCN), the current World Health Organization (WHO) classification of endocrine tumors (fourth edition), the current American Joint Committee on Cancer (AJCC) staging system (eighth edition), the College of American Pathologists (CAP) protocol, and the International Collaboration on Cancer Reporting (ICCR) dataset. The aim is to provide a comprehensive review focused on the definitions and prognostic impacts of these crucial pathologic parameters. View Full-Text
Keywords: extrathyroidal extension; lymphovascular invasion; capsular invasion; AJCC staging extrathyroidal extension; lymphovascular invasion; capsular invasion; AJCC staging
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Xu, B.; Ghossein, R. Critical Prognostic Parameters in the Anatomic Pathology Reporting of Differentiated Follicular Cell-Derived Thyroid Carcinoma. Cancers 2019, 11, 1100.

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