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Brain Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Quantifying Motor Neurone Disease: Advances and Challenges in Developing Biomarkers, Predictive Models and Outcome Measures

edited by Roisin McMackin and

Joke De Vocht

submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open

Keywords: amyotrophic lateral sclerosis; primary lateral sclerosis; progressive muscular atrophy; biomarkers (cognition; neurophysiology; biofluid markers; neuroimaging); modelling; therapeutic development; early detection and diagnosis; precision medicine

(This special issue belongs to the Section Sensory and Motor Neuroscience)

New Advances in Functional Neurosurgery—2nd Edition

edited by

Nicola Montano

submission deadline 31 Dec 2025 | Viewed by 205 | Submission Open

Keywords: functional neurosurgery; trigeminal neuralgia; microvascular decompression; deep brain stimulation; neuromodulation; spinal cord stimulation; epilepsy surgery; neurophysiological intraoperative monitoring; artificial intelligence in neurosurgery; MR-guided focused ultrasound (MRgFUS); laser interstitial thermal therapy (LiTT)

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Advanced Neuromodulation Therapies for Chronic Pain and Psychiatric Disorders

edited by

Valquíria Aparecida da Silva

and Marina de Goes Salvetti

submission deadline 31 Dec 2025 | Viewed by 103 | Submission Open

Keywords: repetitive transcranial magnetic stimulation (rTMS); theta burst stimulation (TBS); chronic pain; treatment-resistant depression; neuromodulation; tDCS; tACS; non-invasive brain stimulation; neuroplasticity; functional connectivity; major depressive disorder and generalized anxiety disorder

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Applications of Cognitive Behavioral Therapy in Mental Disorders

edited by Maria Rita Sergi

submission deadline 31 Dec 2025 | Viewed by 102 | Submission Open

Keywords: psychological well-being; psychotherapy; assessment tools; psychometric validation; clinical psychology; mental health interventions

Multiple Sclerosis Across the Age Spectrum—Beyond Inflammation

edited by

Angelo Bellinvia

submission deadline 1 Jan 2026 | Viewed by 77 | Submission Open

Keywords: multiple sclerosis; neurodegeneration; disability; cognition; functional outcomes; rehabilitation; pediatric-onset; late onset; ageing

Neural Mechanisms Underlying Social Cognition and Emotional Processing

edited by

Atiqah Azhari

submission deadline 10 Jan 2026 | Viewed by 301 | Submission Open

Keywords: social cognition; emotional processing; social neuroscience; developmental neuroscience

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Deep Research into Stroke

edited by

Min Su Kim

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2444 | Submission Open

Keywords: stroke; rehabilitation; neuromodulation; physical therapy; robotics; artificial intelligence; neuroimaging; deep learning; machine learning; exercise

(This special issue belongs to the Section Neurorehabilitation)

Heterogeneity in Cognitive Aging: From Healthy Aging to Neurodegenerative Disease

edited by Yuta Katsumi,

Deepti Putcha

and Bradford C. Dickerson

submission deadline 15 Jan 2026 | 2 articles | Viewed by 1443 | Submission Open

Keywords: aging; cognition; cognitive impairment; subjective cognitive decline; neurodegeneration; Alzheimer’ s disease; prognostication; brain imaging; neuromodulation; interventions

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Beyond Boundaries: Current Advances in Developmental Learning Disorders

edited by Daniela Traficante and

Luisa Girelli

submission deadline 15 Jan 2026 | Viewed by 163 | Submission Open

Keywords: developmental learning disorders; transdiagnostic approach; comorbidity; domain-general components

(This special issue belongs to the Section Neuropsychology)

Non-Invasive Neurotechnologies for Cognitive Augmentation

edited by

Caterina Cinel

Davide Valeriani

and

Saugat Bhattacharyya

submission deadline 15 Jan 2026 | Viewed by 92 | Submission Open

Keywords: neurotechnology; brain– computer interfaces; neuroergonomics; neurorehabilitation; neuroethics; brain stimulation; cognitive augmentation; cognitive enhancement; adaptive neurotechnology

(This special issue belongs to the Section Neural Engineering, Neuroergonomics and Neurorobotics)

Inflammation and Central Nervous System

edited by

Saifudeen Ismael

submission deadline 15 Jan 2026 | Viewed by 85 | Submission Open

Keywords: inflammation; inflammasome; brain injury; neurodegeneration; aging; cognition; brain senescence

(This special issue belongs to the Section Systems Neuroscience)

Anxiety, Depression and Stress

edited by

Sung Joon Cho

submission deadline 18 Jan 2026 | 3 articles | Viewed by 2429 | Submission Open

Keywords: anxiety; depression; stress; NMDA modulators; brain stimulation; anti-inflammatory agents; psychosocial interventions

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Perception Across Disciplines: Exploring the Intersections of Cognitive, Social, Affective and Neural Dimensions

edited by

Yang Zhang

submission deadline 18 Jan 2026 | 1 articles | Viewed by 1135 | Submission Open

Keywords: sensory processing; cognitive systems; perception-action binding; multimodal processing; neural foundations; socio-affective systems; computational models; interdisciplinary research

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

From Bench to Bedside: Motor–Cognitive Interactions—2nd Edition

edited by

Daniele Corbo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8699 | Submission Open

Keywords: motor control and motor learning; movement; cognitive functions; falls; diagnosis; intervention; cognitive– motor training; cognition; fMRI

(This special issue belongs to the Section Cognitive, Social and Affective Neuroscience)

Brain Boosting: Recent Advances in Neurostimulation on Cognitive Functions and Behavioral Performance

edited by

Rinaldo L. Perri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2050 | Submission Open

Keywords: TMS; cognitive functions; behavioral interventions; brain plasticity; addictions; hypnosis; neurostimulation

(This special issue belongs to the Section Behavioral Neuroscience)

Translational EEG Biomarkers in Animal Models: Bridging Pre-Clinical Findings to Human Neuroscience

edited by

Inga Griskova-Bulanova

and Cestmir Vejmola

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1538 | Submission Open

Keywords: EEG; ECoG; biomarker; animal model; pre-clinical

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Advances in the Treatment of Depression, Anxiety, and Other Psychiatric Disorders

edited by Danielle S. Cha

submission deadline 20 Jan 2026 | Viewed by 317 | Submission Open

Keywords: mental health; mental illness; treatment; hypothesis driven; burden of disease

(This special issue belongs to the Section Neuropsychiatry)

Neuropathic Pain: Pathophysiology, Diagnosis and Treatment

edited by Marcos Brioschi and

Areerat Suputtitada

submission deadline 20 Jan 2026 | Viewed by 86 | Submission Open

Keywords: neuropathic pain; pathophysiology; diagnosis; neuroimaging; thermography; artificial intelligence; treatment; rehabilitation; translational research; neuromodulation

(This special issue belongs to the Section Sensory and Motor Neuroscience)

The Gut–Brain Axis: Exploring the Interactions Between the Microbiota and the Nervous System

edited by

Kyle Gobrogge

submission deadline 23 Jan 2026 | 2 articles | Viewed by 5354 | Submission Open

Keywords: gut– brain axis; microbiota– neuron interactions; neurological functions and disorders; animal models; behavior and cognition

(This special issue belongs to the Section Molecular and Cellular Neuroscience)

Emerging Trends in Youth Mental Health

edited by

Ilaria Riboldi

submission deadline 23 Jan 2026 | 1 articles | Viewed by 739 | Submission Open

Keywords: mental health; adolescent mental health; young adult; stress; psychological; social media; climate change; identity development; digital health; school health services

(This special issue belongs to the Section Neuropsychology)

Assessment and Rehabilitation of Cognitive Function in Neurological Disorders

edited by Gilles Naeije

submission deadline 25 Jan 2026 | 1 articles | Viewed by 835 | Submission Open

Keywords: post-stroke cognitive impairment; diaschisis; cerebellum; cortico-cerebellar connectivity; neuromodulation; transcranial cerebellar stimulation; cognitive rehabilitation; functional connectivity

(This special issue belongs to the Section Neurorehabilitation)

Advances in Neurofeedback Research

edited by

Eddy J. Davelaar

submission deadline 25 Jan 2026 | 1 articles | Viewed by 709 | Submission Open

Keywords: neurofeedback; brain– computer interface; neurophenomenology; EEG; rt-fMRI; fNIRS-neurofeedback

(This special issue belongs to the Section Neurotechnology and Neuroimaging)

Current Research in Neurosurgery

edited by

Roberto Altieri

, Manlio Barbarisi and Lucas Alverne Freitas De Albuquerque

submission deadline 30 Jan 2026 | 8 articles | Viewed by 9198 | Submission Open

Keywords: CSN tumor; glioblastoma; skull base; vertebral metastasis; spinal surgery; cerebral aneurysm; AVM; cavernoma; epilepsy

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Brain Tumors: From Molecular Basis to Therapy

edited by Paolo Tini and Giuseppe Minniti

submission deadline 30 Jan 2026 | 5 articles | Viewed by 6689 | Submission Open

Keywords: brain tumors; molecular pathways; targeted therapy; diagnostic biomarkers; predictive biomarkers; therapeutic resistance

(This special issue belongs to the Section Neuro-oncology)

Advances in the Relationship Among Brain, Physical Function, and Exercise Performance

edited by

Luca Petrigna

submission deadline 30 Jan 2026 | 3 articles | Viewed by 3976 | Submission Open

Keywords: physical performance; dual task; cognition; sport; environment; cerebellum; movement; neurodegenerative disease

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Management of Acute Stroke

edited by

Christian Tanislav

and Ali Hammed

submission deadline 30 Jan 2026 | 4 articles | Viewed by 2696 | Submission Open

Keywords: management in acute stroke care; thrombolysis; mechanical thrombectomy; epidemiology in stroke care; stroke unit; cerebral infarction; intracranial bleeding; therapy in acute stroke

(This special issue belongs to the Section Systems Neuroscience)

The Relationship Between Sleep and the Brain: New Insights into Sleep Disorders and Their Effects on Mental Health, Cognition, and Quality of Life

edited by

Giuseppe Barbato

submission deadline 31 Jan 2026 | 5 articles | Viewed by 15498 | Submission Open

Keywords: sleep; REM sleep; circadian rhythm; melatonin; mood disorders; delta sleep; clock genes

(This special issue belongs to the Section Sleep and Circadian Neuroscience)

Advances in Memory and Cognitive Decline Associated with Aging and Alzheimer's Disease

edited by

Pavan Kumar

submission deadline 31 Jan 2026 | 8 articles | Viewed by 15055 | Submission Open

Keywords: neurodegeneration; neuroprotection; neurogenesis; learning and memory; engram; neuro-vascular

(This special issue belongs to the Section Neurodegenerative Diseases)

Advanced Clinical Diagnosis, Evaluation, and Treatment of Psychosis

edited by Giulia Menculini and

Gaia Sampogna

submission deadline 31 Jan 2026 | 5 articles | Viewed by 10839 | Submission Open

Keywords: psychotic disorders; affective psychoses; schizophrenia; antipsychotic drugs; psychosocial treatments; at-risk mental states; biomarkers; early intervention; prevention; social psychiatry

(This special issue belongs to the Section Neuropsychiatry)

Advances in the Diagnosis, Visualization and Treatment of Intracranial Aneurysms and Subarachnoid Hemorrhage

edited by

Serge Marbacher

and Lukas Andereggen

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1496 | Submission Open

Keywords: neurovascular; intracranial aneurysm; subarachnoid hemorrhage; education and teaching; imaging technology; hybrid operating room; augmented reality; cerebrovascular disease; cost-effectiveness; artificial intelligence

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Outcome Measures in Rehabilitation

edited by

Antonio Nardone

and

Irene Aprile

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1365 | Submission Open

Keywords: outcome measures; qualitative measures; quantitative measures; neurologic rehabilitation; musculoskeletal rehabilitation; cardiopulmonary rehabilitation; robotic rehabilitation; movement analysis; gait analysis

(This special issue belongs to the Section Neurorehabilitation)

The Eye as the Window to Brain Science: Fields of Neuroscience Created from Eye Research

edited by

George Ayoub

submission deadline 31 Jan 2026 | 3 articles | Viewed by 1341 | Submission Open

Keywords: sensory system functions; neuroanatomy; neurochemistry; neurophysiology; developmental neurobiology; neurological health and disease

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Mechanisms That Support Music Learning and Development

edited by Jennifer A. Bugos

submission deadline 31 Jan 2026 | Viewed by 261 | Submission Open

Keywords: music; music therapy; neurophysiological research; cognitive development; music cognition; performance; auditory processing

(This special issue belongs to the Section Behavioral Neuroscience)

Deep Brain Stimulation (DBS)—Current Status and Future Directions

edited by Yousef Salimpour

submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open

Keywords: deep brain stimulation; neuromodulation; adaptive closed-loop systems; directional leads; neural biomarkers artificial intelligence; personalization treatment; biocompatible materials

(This special issue belongs to the Section Neurodegenerative Diseases)

Translational Neuroanatomy: Recent Updates and Future Perspectives—2nd Edition

edited by

Grzegorz Wysiadecki

and Andrzej Żytkowski

submission deadline 10 Feb 2026 | 1 articles | Viewed by 201 | Submission Open

Keywords: neuroanatomy; clinical neuroscience; central or peripheral nervous system

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Advancements and Future Directions in Clinical Psychosis

edited by

Marco Colizzi

and

Alessandra Martinelli

submission deadline 10 Feb 2026 | Viewed by 97 | Submission Open

Keywords: clinical psychosis; schizophrenia spectrum disorders; early detection of psychosis; treatment-resistant psychosis; long-term outcomes; personalized psychiatry; digital mental health; AI in psychiatry; neurocognitive interventions; psychosocial therapies; translational psychiatry; interdisciplinary mental health; psychosis clinical trials; innovative diagnostic tools

Novel Insights into Developmental Coordination Disorder

edited by Rita C Silveira and

Renato S. Procianoy

submission deadline 10 Feb 2026 | Viewed by 62 | Submission Open

Keywords: neurodevelopment; prematurity; developmental coordination disorder (DCD); executive function; life-course trajectories; mental health; brain development

(This special issue belongs to the Section Developmental Neuroscience)

Neuropathic Pain: From Physiopathology to Improvements in Diagnosis and Management

edited by Caren Tatiane De David Antoniazzi and Patricia Rodrigues

submission deadline 15 Feb 2026 | Viewed by 143 | Submission Open

Keywords: neuropathic pain; pain mechanisms; neuroinflammation; sensitization; biomarkers; chronic pain; somatosensory system; pain diagnosis; personalized medicine; pain management

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Critical Issues in Motor Control and Sensory–Motor Integration

edited by Simone Gill

submission deadline 15 Feb 2026 | Viewed by 70 | Submission Open

Keywords: motor control; sensorimotor; multisensory; human movement

(This special issue belongs to the Section Sensory and Motor Neuroscience)

Somatosensory Evoked Potentials: Beyond Somesthesis

edited by Ana Maria Cebolla and Guy Cheron

submission deadline 15 Feb 2026 | Viewed by 67 | Submission Open

Keywords: somatosensory evoked potentials; EEG; brain oscillations; movement; gating; modified consciousness states; motor learning

(This special issue belongs to the Section Systems Neuroscience)

Migraine Management: Exploring Neural Clues

edited by Soma Sahai-Srivastava

submission deadline 15 Feb 2026 | Viewed by 47 | Submission Open

Keywords: migraine management; translational research; non-drug treatment; neural cues; non-pharmacological treatment

(This special issue belongs to the Section Neuropharmacology and Neuropathology)

The Role of Glia in Inflammatory Processes

edited by

Charles Elias Assmann

and Margarete Dulce Bagatini

submission deadline 16 Feb 2026 | 4 articles | Viewed by 4862 | Submission Open

Keywords: neuroinflammation; neurodegenerative and psychiatric disorders; microglia; astrocytes; purinergic signaling; bioactive and natural compounds; immunopharmacology and immunotoxicology; oxidative and nitrosative stress; neuroimaging; neuroscience and behavior

(This special issue belongs to the Section Neuroglia)

Language, Communication and the Brain—2nd Edition

edited by

Jayanthi Sasisekaran

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2007 | Submission Open

Keywords: cognitive; attention; working memory; executive functions; linguistic; language planning; speech production; fluency; sensorimotor; hearing; speech and language production; neurotypical; neurodiverse; autism; apraxia; dysarthria; stuttering; speech sound disorders; artificial intelligence; data science; theoretical; data-driven

(This special issue belongs to the Section Neurolinguistics)

Advanced Technologies and Approaches for Understanding and Treating Psychological Disorders

edited by

Alessandra Vergallito

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1425 | Submission Open

Keywords: psychological disorders; psychological well-being; psychological interventions; non-invasive brain stimulation; digital therapies; artificial intelligence; virtual reality; pharmacological interventions

(This special issue belongs to the Section Neuropsychiatry)

Advances in Cerebral Aneurysm Surgery: The Latest Technologies and Techniques

edited by Andreas Gruber

submission deadline 20 Feb 2026 | Viewed by 91 | Submission Open

Keywords: microsurgical aneurysm clipping; preoperative simulation; hybrid neurovascular surgery; skills-lab training; intraoperative monitoring and imaging

(This special issue belongs to the Section Neurosurgery and Neuroanatomy)

Non-Invasive Neural Technology in Analysing Spinal Cord Activity

edited by

Giulio Gabrieli

submission deadline 20 Feb 2026 | Viewed by 54 | Submission Open

Keywords: spinal cord; non-invasive recording; electrophysiology; neurotechnology; signal processing; artifact reduction; wearable sensors; machine learning

(This special issue belongs to the Section Neural Engineering, Neuroergonomics and Neurorobotics)

Cognitive Training in Health and Disease

edited by

María del Carmen Carcelén-Fraile

submission deadline 22 Feb 2026 | Viewed by 63 | Submission Open

Keywords: cognitive training; child development; adolescence; executive functions; cognitive stimulation; mental health; neurodevelopmental disorders; healthy aging; education and cognition

(This special issue belongs to the Section Cognitive Neuroscience)

Eye-Tracking Monitoring of Neurological and Psychiatric Conditions Across Life Span

edited by