Advances in Parkinson's Disease and Movement Disorders

Dear Colleagues,

Parkinson’s disease and related movement disorders remain a major challenge in neurology due to their complex pathophysiology, progressive course, and impact on quality of life. Recent advances are reshaping both our understanding and management of these conditions, with research into genetic mutations, mitochondrial dysfunction, and neuroinflammation highlighting disease variability and opening new paths to targeted molecular therapies. Modern neuroimaging and fluid biomarkers, including α-synuclein and tau seeding assays, are improving early diagnosis, refining clinical classification, and strengthening clinical trials designs. Moreover, therapeutic options have expanded beyond dopamine replacement, with advances in continuous drug delivery, new non-dopaminergic agents, and important technological progress in device-assisted interventions such as deep brain stimulation and focused ultrasound (also applied in cases of tremor and dystonia). Beyond Parkinson’s, important breakthroughs include the approval of omaveloxolone, the first disease-modifying therapy for Friedreich’s ataxia, and the use of VMAT2 inhibitors, which have improved care in hyperkinetic disorders such as tardive dyskinesia and chorea. At the same time, digital health technologies—from wearable sensors to AI-driven analytics—are transforming longitudinal monitoring and supporting more personalized care. Given this background, this Special Issue will highlight multidisciplinary contributions that integrate basic science, clinical practice, and technological innovation across the spectrum of movement disorders.

Dr. Gabriele Imbalzano
Dr. Domiziana Rinaldi
Guest Editors

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