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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Prefrontal Cortex in Cognition and Diseases

edited by

Xuehan Zhang

submission deadline 31 Jan 2026 | Viewed by 62 | Submission Open

Keywords: executive function; working memory; behavioral inhibition; attention; anxiety; social behavior; ADHD (attention-deficit hyperactivity disorder); schizophrenia; MDD (major depressive disorder); AD (Alzheimer's disease); PD (Parkinson’ s disease)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Biochemical and Molecular Perspectives on Engineered Nanoparticles for Cancer Therapy

edited by

Luca Vanella

and

Valeria Consoli

submission deadline 10 Feb 2026 | Viewed by 187 | Submission Open

Keywords: cancer; oxidative stress; engineered nanoparticles (ENPs); drug delivery; biochemical processes; ferroptosis; apoptosis; cell death; molecular interactions; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Innovations in Bone and Craniofacial Tissue Engineering: From Biomaterials and Mechanobiology to Clinical Applications

edited by Zhekai Hu

submission deadline 15 Feb 2026 | Viewed by 165 | Submission Open

Keywords: bone tissue engineering; craniofacial regeneration; biomaterials and scaffolds; stem cells and exosomes; mechanobiology and orthodontic forces; osteoimmunology; oxidative stress modulation; gene/drug delivery; translational research; periodontal and alveolar bone regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Emerging Trends in Malignant Mesothelioma

edited by Yuan Xu

submission deadline 20 Feb 2026 | Viewed by 263 | Submission Open

Keywords: mesothelioma; asbestos; novel therapeutic strategies; treatment resistance; multi-omics analysis

(This special issue belongs to the Section Cancer Biology and Oncology)

Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications

edited by

Simone Patergnani

and

Alberto Danese

submission deadline 20 Feb 2026 | Viewed by 126 | Submission Open

Keywords: autophagy; pathology; physiology; therapy; methods

(This special issue belongs to the Section Cell Biology and Pathology)

Obstructive Sleep Apnea: Mechanisms, Comorbidities, and Optimization of Emerging and Established Therapies

edited by

Ivana Pavlinac Dodig

and

Renata Pecotic

submission deadline 25 Feb 2026 | 3 articles | Viewed by 5051 | Submission Open

Keywords: obstructive sleep apnea; sleep-disordered breathing; pathophysiology; cardiometabolic comorbidities; precision medicine; CPAP; sleep diagnostics; biomarkers; neurocognitive impairment; new therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Current Trends in Diabetic Foot Disease

edited by Xuefeng Yu

submission deadline 27 Feb 2026 | Viewed by 228 | Submission Open

Keywords: diabetes; diabetic foot; endocrinology; metabolic disease

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Pathology, Complications and Prognosis of Type 1 Diabetes

edited by Maurizio Delvecchio

submission deadline 27 Feb 2026 | Viewed by 63 | Submission Open

Keywords: type 1 diabetes mellitus; autoimmune β -cell destruction; diabetic complications; microvascular and macrovascular damage; diabetic ketoacidosis; glycemic control; disease prognosis; immunopathogenesis

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Advanced Research of Gut Microbiota in Health and Diseases—2nd Edition

edited by

Andrea Piccioni

and

Federico Rosa

submission deadline 28 Feb 2026 | 8 articles | Viewed by 21837 | Submission Open

Keywords: microbiota; gut; dysbiosis; gut microbiome; pathological conditions; metabolic disorders; autoimmune disease; inflammatory disorders; degenerative diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

Cellular and Molecular Biology of Neurodegenerative Disorders

edited by

Marta Lualdi

submission deadline 28 Feb 2026 | 5 articles | Viewed by 16929 | Submission Open

Keywords: neurodegeneration; omics; biomarkers; systems biology; disease-modifying therapies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Glioblastoma: Pathogenetic, Diagnostic and Therapeutic Perspectives

edited by

Thi Thu Trang Nguyen

submission deadline 28 Feb 2026 | 5 articles | Viewed by 15548 | Submission Open

Keywords: drug delivery methods (TTFields; nanoparticles); immunotherapy; oncolytic virotherapy; cell metabolism (glycolysis; OXPHOS; fatty acid oxidation); epigenetic; biomarkers; gene therapy (CRISPR/Cas9)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Cellular and Pathogenesis Mechanisms in Oral Cancer

edited by

Jun-Ichi Tanuma

submission deadline 28 Feb 2026 | 5 articles | Viewed by 14146 | Submission Open

Keywords: oral carcinogenesis; oral cancer model; OSCC; oral cytology; biomarkers; targeted therapies; precision medicine; bioinformatics

(This special issue belongs to the Section Molecular and Translational Medicine)

Natural Product for the Interventions of Chronic Diseases: From Source to Therapy

edited by

Qilei Chen

submission deadline 28 Feb 2026 | 2 articles | Viewed by 14004 | Submission Open

Keywords: natural products; chronic diseases; drug discovery; pharmacodynamics; pharmacokinetics; nanotechnology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Musculoskeletal Injuries: Clinical, Radiological, and Biochemical Evaluation in Orthopedics

edited by

Carlo Biz

Elisa Belluzzi

and

Pietro Ruggieri

submission deadline 28 Feb 2026 | 6 articles | Viewed by 13930 | Submission Open

Keywords: orthopedic surgery; sports injuries; bone cancer; diabetic foot; clinical evaluation; radiological evaluation; biomarkers; prognostic markers

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Cell Death

edited by

Adrian-Bogdan Țigu

and Madalina Nistor

submission deadline 28 Feb 2026 | 4 articles | Viewed by 11680 | Submission Open

Keywords: cell death pathways; apoptosis; necrosis; biomarkers; therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Progress in Cardiovascular Pharmacology

edited by

Pietro Scicchitano

and

Francesco Massari

submission deadline 28 Feb 2026 | 3 articles | Viewed by 9789 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pharmacology; target therapies; molecular pharmacology; heart failure; preventive cardiology; atherosclerosis

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Feature Reviews in Mesenchymal Stem Cells

edited by

Debora Lo Furno

and

Giuliana Mannino

submission deadline 28 Feb 2026 | 2 articles | Viewed by 9553 | Submission Open

Keywords: mesenchymal stem cells; tissue repair and regeneration; immunomodulatory functions

(This special issue belongs to the Section Cell Biology and Pathology)

Neuroendocrine Neoplasia and Endocrine Tumors: Pathogenic Features, Prognostic Markers and New Therapeutic Approaches

edited by

Mara Carsote

submission deadline 28 Feb 2026 | 5 articles | Viewed by 8791 | Submission Open

Keywords: neuroendocrine tumors; endocrine tumors; somatostatin analogues; carcinoid syndrome; PRRT; mTOR inhibitor; lymph node; neuroendocrine marker; hormone; ki67

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Biomarker Discovery for Cardiovascular Disease

edited by

Qin Fu

and

Haijun Liu

submission deadline 28 Feb 2026 | 6 articles | Viewed by 7702 | Submission Open

Keywords: cardiovascular disease; genomics; transcriptomics; proteomics; metabolomics; multiomics; gene sequencing; liquid chromatography/gas chromatography tandem mass spectrometry; diagnostic biomarkers; biomedicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Liquid Biopsy from Technological Innovation to Therapeutic Intervention

edited by

Mohamed Kamal

and

James Hicks

submission deadline 28 Feb 2026 | 4 articles | Viewed by 7241 | Submission Open

Keywords: liquid biopsy; biomarkers; circulating tumor cells

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Breast Diseases and Histopathology

edited by Michał Budzik

submission deadline 28 Feb 2026 | 3 articles | Viewed by 6050 | Submission Open

Keywords: breast cancer; breast diseases; histopathology; biomarkers; screening; diagnosis; early detection; tumor microenvironment; pathophysiology; molecular biology

(This special issue belongs to the Section Cell Biology and Pathology)

Progress in Nanotechnology-Based Therapeutic Strategies

edited by Ambra Del Grosso and Mariacristina Gagliardi

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5928 | Submission Open

Keywords: nanotechnology-based therapies; targeted drug delivery; nanoparticles; nanostructures; cancer treatment; cardiovascular diseases; neurodegenerative diseases; infectious diseases; lysosomal storage disorders; regenerative medicine; tissue engineering; gene therapy; biochemical diagnostics; omics approaches; biological barriers

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Diabetes: Comorbidities, Therapeutics and Insights (3rd Edition)

edited by

Tomislav Bulum

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5728 | Submission Open

Keywords: diabetes; complications; diabetic retinopathy; diabetic neuropathy; diabetic nephropathy; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Animal Models for the Study of Human Diseases

edited by

Yong-He Ding

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5514 | Submission Open

Keywords: animal models; zebrafish; mice; rats

(This special issue belongs to the Section Molecular and Translational Medicine)

Urticaria: New Insights into Pathogenesis, Diagnosis and Therapy

edited by

Angela Rizzi

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4775 | Submission Open

Keywords: acute urticaria; chronic urticaria; pathogenesis; mast cells; biomarkers; diagnosis; biologicals

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Ion Channels and Transporters in Human Health and Diseases (2nd Edition)

edited by Teresa Soda

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4108 | Submission Open

Keywords: ion channels; transporters; ion pumps; voltage-gated channels; ionotropic receptors; TRP channels; store-operated channels; piezo channels; NALCN channels; inositol-1; 4; 5-receptors; ryanodine receptors; two-pore channels; synaptic transmission; channelopathies; neurodegenerative disorders; cardiovascular disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Research in Ocular Pathology

edited by

Sorin Lucian Bolintineanu

and

Laura Andreea Ghenciu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3914 | Submission Open

Keywords: molecular pathology; ocular diseases; biomarkers; diabetic retinopathy; glaucoma; age-related macular degeneration; thyroid eye disease; inflammatory pathways; oxidative stress; angiogenesis; neurodegeneration; gene therapy; cell therapy; precision medicine; ocular imaging

(This special issue belongs to the Section Molecular and Translational Medicine)

Endothelial Dysfunction: From a Pathophysiological Mechanism to a Potential Therapeutic Target—3rd Edition

edited by

Pasquale Ambrosino

and

Guido Grassi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3712 | Submission Open

Keywords: endothelial function; arterial stiffness; vascular medicine; cardiovascular risk; nitric oxide; reactive oxygen species; interleukins; inflammation; biomarkers

(This special issue belongs to the Section Cell Biology and Pathology)

Kidney Diseases in Critical Ill Patients

edited by

Caterina Carollo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3551 | Submission Open

Keywords: acute kidney disease; critical care; beside diagnostics; point of care ultrasounds; dialysis

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Cardiovascular Remodeling: Molecular Mechanisms and Therapeutic Targets

edited by

Elena Kaschina

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3349 | Submission Open

Keywords: cardiac remodeling; vascular remodeling; ageing; pathogenesis; molecular mechanisms; diagnostics; therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Skeletal Muscle Metabolism

edited by Lorenzo Sanesi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3323 | Submission Open

Keywords: energy metabolism; mebabolic signaling pathways; homeostasis; myokines; aging; atrophy; muscle metabolism

(This special issue belongs to the Section Molecular and Translational Medicine)

Biotechnology in the Treatment and Management of Hearing Loss

edited by

Alessandro Castiglione

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3160 | Submission Open

Keywords: hearing loss; gene therapy; regenerative medicine; cochlear implants; nanotechnology stem cell therapy; CRISPR-Cas9; auditory prosthetics; artificial intelligence; auditory regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Mechanisms and Therapeutic Approaches for Hepatocellular Carcinoma

edited by Lanqi Gong,

Xinyuan Guan

and Yu Zhang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2797 | Submission Open

Keywords: hepatocellular carcinoma; HCC diagnosis and prognosis; HCC mechanisms; therapeutic resistance; immunotherapy; targeted therapy; personalized medicine; drug development; clinical trials; translational studies

(This special issue belongs to the Section Cancer Biology and Oncology)

Autophagy, Apoptosis and Cancer: 2025 Update

edited by

Md Ataur Rahman

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2748 | Submission Open

Keywords: autophagy; apoptosis; glioblastoma; hypoxia-inducible factors (HIFs); female fertility and ovarian cancer; nanoparticle-based drug delivery; bioactive natural products

(This special issue belongs to the Section Cancer Biology and Oncology)

Growth Hormone Disorders and Their Related Diseases: From Pathophysiology to Therapeutic Approaches

edited by

Giorgio Sodero

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2663 | Submission Open

Keywords: growth; growth hormone deficiency; GH; IGF-1; pediatric endocrinology

(This special issue belongs to the Section Endocrinology and Metabolism Research)

New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition

edited by

Evangelos Koustas

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2519 | Submission Open

Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurodegenerative Diseases: From Mechanisms to Therapeutic Approaches, 2nd Edition

edited by

Marie-Lise Maddelein

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2443 | Submission Open

Keywords: neurodegenerative diseases; neurons; mechanism

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Application of Artificial Intelligence in Biomedicines

edited by

Raffaele Pugliese

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2375 | Submission Open

Keywords: artificial intelligence; generative artificial intelligence; precision medicine; clinical decision support; drug discovery; personalized therapy; trustworthy AI

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Advances in Oral Medicine—2nd Edition

edited by

Arkadiusz Dziedzic

and

Robert Kubina

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2332 | Submission Open

Keywords: oral medicine; oral manifestations of systemic conditions; drug-induced lesions; oral pathologies; head and neck cancer; autoimmune; oral lesions; bisphosphonates; systemic pharmacotherapy; infectious diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

Pluripotent Stem Cells: Current Understanding and Future Directions—2nd Edition

edited by

Aline Yen Ling Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2111 | Submission Open

Keywords: induced pluripotent stem cells; iPSC generation; somatic reprogramming; iPSC-derived cells; cell therapy; exosome therapy; therapeutic application; drug screening

(This special issue belongs to the Section Cell Biology and Pathology)

Microcirculation, Thrombosis, and Inflammation in Peripheral Artery Disease and in the Brain

edited by

Patricia Pia Wadowski

and

Henriette Löffler-Stastka

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1949 | Submission Open

Keywords: microcirculation; thrombosis; inflammation; peripheral artery disease; brain

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathogenesis and Treatment of Mycobacterium Tuberculosis Infection

edited by Sajid Nadeem

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1872 | Submission Open

Keywords: mycobacterium tuberculosis; pathogenesis; host-directed therapy; inflammation; necrosis; innate and adaptive immunity

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Congenital Heart Disease: Diagnosis, Treatment and Prognosis

edited by

Gaetano Thiene

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1574 | Submission Open

Keywords: adult congenital heart disease; eisenmenger's syndrome; endocarditis; thromboprophylaxis

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Precision Cancer Therapy

edited by

Yongheng Chen

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1429 | Submission Open

Keywords: personalized cancer therapy; targeted therapy; immunotherapy; cancer genomics; cancer biomarker; liquid biopsy; CAR-T cell therapy; kinase inhibitor; combination therapy; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

Pathophysiology and Therapeutic Innovations in Skin and Appendage Disorders

edited by

Xuming Zhu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1362 | Submission Open

Keywords: skin disorders; skin development; skin pathophysiology; tumorigenesis; psoriasis; atopic dermatitis; acne; innovative therapies; molecular dermatology; translational skin research

(This special issue belongs to the Section Cell Biology and Pathology)

Progress in Cytotoxicity of Biomaterials

edited by Lakkamraju Vijayalakshmi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1243 | Submission Open

Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety

(This special issue belongs to the Section Biomedical Engineering and Materials)

Multisystem Crosstalk in Health and Disease

edited by

Mehmet Bostancıklıoğlu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1232 | Submission Open

Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host– microbe interactions; metabolic regulation

(This special issue belongs to the Section Endocrinology and Metabolism Research)

New Advances in Wound Healing and Skin Regeneration

edited by

Bingrong Zhou

and Siqi Fu

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1223 | Submission Open

Keywords: wound healing; skin regeneration; biomaterials; stem cell therapy; tissue engineering; bioactive dressings; 3D bioprinting; growth factors; chronic wounds; regenerative medicine

Innovations in Nanomedicine for Disease Management

edited by Anna Valentino and

Raffaele Conte

submission deadline 28 Feb 2026 | 1 articles | Viewed by 905 | Submission Open

Keywords: nanomedicine; nanoparticles; smart drug delivery; personalized medicine; minimally invasive treatments; gene therapy; regenerative medicine

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Immune Cell Reprogramming: Molecular Mechanisms and Therapeutic Approaches

edited by

Santarsiero Anna

Vittoria Infantino

and Paolo Convertini

submission deadline 28 Feb 2026 | 1 articles | Viewed by 756 | Submission Open

Keywords: immune cell reprogramming; immunometabolism; macrophage activation; gene expression regulation; cell signaling; innate immunity; adaptive immunity; metabolic disorders; chronic inflammation; targeted therapies

(This special issue belongs to the Section Immunology and Immunotherapy)

Displaying special issue 301-350 on page 7 of 15.

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