Immune Cell Reprogramming: Molecular Mechanisms and Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 58
Special Issue Editors
Interests: macrophage activation; immunometabolism; gene expression; transcriptional regulation; epigenetics; cell signaling
Special Issues, Collections and Topics in MDPI journals
Interests: macrophage activation; immunometabolism; gene expression; transcriptional regulation; epigenetics; cell signaling; mitochondria
Special Issues, Collections and Topics in MDPI journals
Interests: macrophage activation; immunometabolism; transcriptional regulation; post-transcriptional regulation; miRNA; splicing mechanisms; liver
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immune cell function is tightly linked to cellular metabolism, with metabolic reprogramming now recognized as a central driver—not merely a consequence—of both innate and adaptive immune responses in health and disease. Key metabolic pathways, such as glycolysis, oxidative phosphorylation, and fatty acid oxidation, influence not only energy production but also gene expression, signaling, and epigenetic modifications, ultimately shaping the phenotypes of immune cells. Moreover, metabolic intermediates generated through these pathways can act as immunomodulators, further impacting immune function. The disruption of immune–metabolic interactions contributes to chronic inflammation, a defining feature of many metabolic disorders, such as obesity, type 2 diabetes, cancer, and autoimmune diseases.
For this Special Issue, we invite researchers to contribute their valuable work, whether in the form of original research or review articles, on the mechanistic underpinnings and translational potential of immune cell reprogramming, Topics of interest include signaling networks, metabolic pathways, gene expression regulation, and epigenetic modulation, as well as innovative therapeutic strategies such as immunostimulation and targeted modulation of immunometabolic circuits.
Dr. Santarsiero Anna
Dr. Vittoria Infantino
Dr. Paolo Convertini
Guest Editors
Manuscript Submission Information
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Keywords
- immune cell reprogramming
- immunometabolism
- macrophage activation
- gene expression regulation
- cell signaling
- innate immunity
- adaptive immunity
- metabolic disorders
- chronic inflammation
- targeted therapies
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