Application of Artificial Intelligence in Biomedicines

Dear Colleagues,

Artificial Intelligence (AI) plays an increasingly transformative role in biomedicine, enabling breakthroughs across a wide range of domains, ranging from accelerating drug discovery and enhancing diagnostic accuracy to enabling precision medicine and augmenting surgical procedures. This Special Issue will showcase the latest advances, innovative methodologies, and real-world applications of AI in biomedical research.

AI and Generative AI have demonstrated an exceptional capacity to analyze complex, high-dimensional datasets; uncover hidden patterns; and generate predictive models that support data-driven decision-making in clinical and research environments. With the advent of deep learning, reinforcement learning, and other advanced techniques, AI is rapidly redefining the frontiers of biomedical science.

Hence, in this Special Issue, we welcome original research articles and reviews that explore—but are not limited to—the following topics:

Drug Discovery and Development

• AI-driven identification and optimization of drug candidates;
• Predictive models for drug efficacy, toxicity, and pharmacokinetics;
• Computational design of bioactive molecules and peptides. 

Disease Diagnosis and Prognosis

• AI-based medical image analysis (e.g., MRI, CT, histopathology);
• Predictive analytics for early disease detection and progression modeling. 

Personalized and Precision Medicine

• AI algorithms for individualized therapy recommendations;
• Monitoring and adaptive treatment strategies using AI. 

Biomedical Research and Discovery

• Generative AI for hypothesis generation and experimental design;
• AI in clinical decision support;
• Knowledge discovery from scientific literature using natural language processing (NLP) and Large Langue Models (LLMs);
• Ensuring fairness, transparency, and accountability in AI models;
• Ethical principles for trustworthy AI in personalized medicine. 

This Special Issue will bring together contributions from academia and industry to provide a comprehensive overview of how AI is shaping the future of biomedicine. By highlighting both opportunities and challenges, including those related to ethics and trust, we hope to foster interdisciplinary dialogue and drive the responsible integration of AI into biomedical science.

Dr. Raffaele Pugliese
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• artificial intelligence
• generative artificial intelligence
• precision medicine
• clinical decision support
• drug discovery
• personalized therapy
• trustworthy AI