Pathogenesis and Treatment of Mycobacterium Tuberculosis Infection
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 824
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tuberculosis (TB), caused by a recalcitrant pathogen, Mycobacterium tuberculosis (Mtb), remains a significant global health concern. Despite advances in diagnosis and treatment, approximately 10 million new cases of TB are diagnosed each year, with over a million people succumbing to it and latently infecting approximately a quarter of the worldwide population. Poverty, co-infection with diseases like acquired immunodeficiency syndrome (AIDS) and the emergence of drug-resistant strains of Mtb, likely due to extensive use of antibiotics, have further complicated the treatment landscape. Understanding the pathogenesis of Mtb, which comprises the phases of invasion, proliferation, dormancy and active disease, is of utmost importance in identifying important biological targets that lead to novel treatments. In addition to the therapeutics targeting pathogen-related processes directly, there is also an urgent need to boost the host immune response by employing host-directed therapy (HDT), which can significantly reduce the dose and duration of anti-tubercular drugs, leading to reduced incidence of drug resistance.
This Special Issue welcomes original articles and reviews focused on understanding the pathogenesis of Mtb in latent and active disease states inside the host. To improve treatment effectiveness, articles in this Special Issue will help us to understand the molecular mechanisms of tuberculosis, identify novel therapeutic targets and employ HDT modalities to address immunopathology and survival mechanisms.
Dr. Sajid Nadeem
Guest Editor
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Keywords
- mycobacterium tuberculosis
- pathogenesis
- host-directed therapy
- inflammation
- necrosis
- innate and adaptive immunity
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