Autophagy, Apoptosis and Cancer: 2025 Update
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 1214
Special Issue Editor
Interests: autophagy; apoptosis; glioblastoma; bioactive natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autophagy and apoptosis are essential cellular mechanisms with significant consequences for cancer initiation, advancement, and treatment. Autophagy serves a dual function in cancer, functioning as a tumor suppressor in the first stages by eliminating damaged cellular components, while facilitating tumor survival in subsequent stages by boosting adaptation to stress. Apoptosis, the mechanism of programmed cell death, is precisely regulated in cancer, with its avoidance serving as a hallmark of carcinogenesis. This Special Issue seeks to offer current knowledge of these intricate pathways in cancer biology for 2025.
The interaction between autophagy and apoptosis is particularly crucial in aggressive malignancies such as glioblastoma, where therapeutic resistance and the tumor microenvironment, notably hypoxia-inducible factors (HIFs), complicate standard treatments. This Special Issue's articles will examine new insights into these pathways, emphasizing their regulation under hypoxic conditions and their role in tumor adaptation and resistance.
The topic of discussion will encompass female fertility and ovarian cancer, elucidating the roles of autophagy and apoptosis in ovarian aging and cancer progression. The capacity of bioactive natural compounds to influence these pathways offers a promising opportunity for innovative therapeutics. The utilization of nanoparticle-based drug delivery methods to target autophagy and apoptosis pathways is advancing rapidly and will be a primary area of attention.
This Special Issue seeks submissions that investigate molecular pathways, therapeutic targets, and novel strategies in cancer treatment. Submissions of original research articles, complete reviews, and short communications concerning autophagy, apoptosis, glioblastoma, female fertility-associated malignancies, and advanced drug delivery methods are welcome. This Special Issue promises to advocate for interdisciplinary collaboration and facilitate advancements in cancer therapy through the combination of molecular biology, pharmacology, and clinical applications.
Dr. Md Ataur Rahman
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- autophagy
- apoptosis
- glioblastoma
- hypoxia-inducible factors (HIFs)
- female fertility and ovarian cancer
- nanoparticle-based drug delivery
- bioactive natural products
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