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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights in Radiotherapy: Bridging Radiobiology and Oncology

edited by

Yuan-Hao Lee

and I-Tsang Chiang

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1867 | Submission Open

Keywords: tissue-sparing effect; bystander effect; factors that affect radiation-induced lethality; radiation-induced abscopal effect; mechanisms that enhance tissue radiosensitivity; synergistic effect from radiotherapy and immunotherapy; regulatory perspectives on medical radiation safety

(This special issue belongs to the Section Cancer Biology and Oncology)

Biomarkers for Neurodegenerative Disorders: From Bench to Bedside

edited by George P. Paraskevas

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1818 | Submission Open

Keywords: dementia; Alzheimer’ s disease; frontotemporal dementia; dementia with Lewy bodies; parkinsonism; tau protein; TDP-43; α -synuclein; Tau-PET; amyloid-PET

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neurodevelopmental and Neuropsychiatric Disorders in Animal Models

edited by Yael Abreu-Villaça

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1422 | Submission Open

Keywords: mood disorder; mental disorder; substance use disorder; autism spectrum disorder (ASD); attention-deficit/hyperactive disorder (ADHD); depression and anxiety disorders; schizophrenia; bipolar disorder; epilepsy; eating disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Endocrine Cancer Biology and Oncology

edited by

Piotr Glinicki

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1267 | Submission Open

Keywords: thyroid and parathyroid tumors; adrenal tumors (hormonally active and inactive; ACC); neuroendocrine tumors (NEN); pituitary neuroendocrine tumors (PiNETs)

(This special issue belongs to the Section Cancer Biology and Oncology)

Innovative Biomaterials and Advanced Techniques for Bone Regeneration Applications

edited by

Antonio Apicella

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1210 | Submission Open

Keywords: biomaterials; bone regeneration; osteointegration; 3D printing; biomimetic design

(This special issue belongs to the Section Biomedical Engineering and Materials)

Cardiomyopathies and Heart Failure: Charting the Future—2nd Edition

edited by Ali Amr

submission deadline 30 Nov 2025 | 1 articles | Viewed by 992 | Submission Open

Keywords: cardiomyopathies; heart failure; risk stratification; management of cardiomyopathies; cardiac imaging; telemedicine

(This special issue belongs to the Section Cell Biology and Pathology)

Diagnosis, Management and Treatment of Rheumatoid Arthritis

edited by Yong Feng

submission deadline 30 Nov 2025 | 1 articles | Viewed by 831 | Submission Open

Keywords: rheumatoid arthritis; autoimmune disorder; synovial inflammation; genetic factors; signaling pathway; targeted therapies

(This special issue belongs to the Section Molecular and Translational Medicine)

Phenotypes and Endotypes in Interstitial Lung Diseases—Second Edition

edited by

Francesco Amati

submission deadline 30 Nov 2025 | 1 articles | Viewed by 710 | Submission Open

Keywords: interstitial lung diseases (ILDs); heterogeneity; pathogenesis; progressive pulmonary fibrosis (PPF); molecular biomarkers

(This special issue belongs to the Section Immunology and Immunotherapy)

Advancing Pharmacogenetics and Pharmacogenomics in Pre-Clinical Research: Unveiling New Avenues for Precision Medicine

edited by

Shengying Qin

and

Cong Huai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 545 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; precision medicine; individualized medicine

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Decoding Colorectal Cancer: Innovations in Biomarkers, Microbiota, and Therapeutic Resistance

edited by

Yinghao Cao

submission deadline 30 Nov 2025 | 1 articles | Viewed by 540 | Submission Open

Keywords: colorectal cancer; tumor biomarkers; nanomaterials; drug delivery; microbiome– tumor interaction; therapeutic resistance; exosomes; tumor microenvironment; prognostic model; neoadjuvant therapy; conversion therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

The Interplay Between miRNA and Mitochondrial Dysfunction in Neurodegenerative Diseases

edited by

Mariano Catanesi

submission deadline 30 Nov 2025 | Viewed by 380 | Submission Open

Keywords: miRNA; neurodegenerative diseases; mitochondrial dysfunction; aging; gene expression

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Molecular Mechanisms of Normal and Malignant Hematopoiesis: 2nd Edition

edited by

Myunggon Ko

submission deadline 30 Nov 2025 | Viewed by 371 | Submission Open

Keywords: hematopoietic stem cells; self-renewal; differentiation; hematological malignancies; molecular mechanisms; genetic factors; epigenetic factors; transcriptional regulation; HSC niche; targeted therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Cancer Genetics and Epigenetics

edited by

Zheng-Yuan Su

submission deadline 30 Nov 2025 | Viewed by 295 | Submission Open

Keywords: cancer genetics; epigenetics; DNA methylation; histone modifications; non-coding RNAs; tumor heterogeneity; drug resistance; biomarkers; precision oncology; personalized therapy

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advances in Molecular Research on Physical Activity, Sleep and Cognitive Function

edited by

Yanwei You

submission deadline 30 Nov 2025 | Viewed by 258 | Submission Open

Keywords: physical activity; sleep; cognitive function; molecular mechanisms; neuroplasticity; oxidative stress; inflammation; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular and Histopathological Background of Diabetic Neuropathy

edited by

Mária Bagyánszki

submission deadline 30 Nov 2025 | Viewed by 254 | Submission Open

Keywords: diabetic neuropathy; insulin; hyperglycaemia; peripheral neuropathy; autonomic neuropathy; proximal neuropathy; enteric neuropathy; mononeuropathy

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances of Microbiome in Human Cancers

edited by

Weg M. Ongkeko

submission deadline 30 Nov 2025 | Viewed by 252 | Submission Open

Keywords: human microbiome; gut microbiota; tumor-resident microbes; translational research; biomarkers; computational biology

(This special issue belongs to the Section Cancer Biology and Oncology)

The Role of HOX Genes in Particular Cancers

edited by

Renata Freitas

submission deadline 30 Nov 2025 | Viewed by 245 | Submission Open

Keywords: HOX genes; anti-cancer drugs; cell memory program; epigenetic regulation

(This special issue belongs to the Section Cancer Biology and Oncology)

Animal Models of Human Pathology: Revision, Relevance and Refinements (4th Edition)

edited by

Martina Perše

submission deadline 30 Nov 2025 | Viewed by 242 | Submission Open

Keywords: animal models; biomarkers; human disease; pathology; translation; mechanisms; nephrology; gastroenterology; urology; neuroscience; cancer; experimental design; reproducibility; refinements

(This special issue belongs to the Section Molecular and Translational Medicine)

Hepatocellular Carcinoma: From Pathophysiology to Therapeutic Approaches Treatment

edited by

Wasim A. Dar

submission deadline 30 Nov 2025 | Viewed by 224 | Submission Open

Keywords: hepatocellular carcinoma; pathophysiology; therapeutic interventions

(This special issue belongs to the Section Cancer Biology and Oncology)

Therapeutic Resistance in Oral Cancer: Mechanisms, Biomarkers, and Novel Strategies to Restore Treatment Responses

edited by

Vui King Vincent-Chong

submission deadline 30 Nov 2025 | Viewed by 219 | Submission Open

Keywords: oral cancer; OSCC; chemotherapy; radiotherapy; immunotherapy; therapeutic resistance; HNSCC; biomarker; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Neurophysiology and the Treatment of Parkinson’s Disease

edited by

Giorgia Sciacca

submission deadline 30 Nov 2025 | 1 articles | Viewed by 215 | Submission Open

Keywords: movement disorders; hypokinetic movement disorders; Parkinson’ s disease; levodopa; treatment; neurophysiology; neuroplasticity; motor learning

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Lymphoma: Second Edition

edited by

Socorro María Rodríguez-Pinilla

and

Marta Rodríguez Moreno

submission deadline 30 Nov 2025 | Viewed by 207 | Submission Open

Keywords: lymphoma; cancer; gene expression; mutational analysis; target; therapy; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Exercise-Induced Physiological Responses: From Oxidative Stress to DNA Alterations

edited by

Robert Stawski

submission deadline 30 Nov 2025 | Viewed by 207 | Submission Open

Keywords: exercise-induced oxidative stress; reactive oxygen species (ROS); molecular adaptations to exercise; epigenetic modifications in exercise; DNA damage and repair; cell-free DNA; extracellular DNA; inflammation and exercise; DNA alterations

(This special issue belongs to the Section Cell Biology and Pathology)

Application of New Technologies in Drug Delivery

edited by Venkata Raman Kallakunta

submission deadline 30 Nov 2025 | Viewed by 205 | Submission Open

Keywords: drug delivery; new technologies; nanoparticles; self-emulsifying drug delivery systems (SEDDSs); hot melt extrusion (HME); gene editing; 3D printing

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Coronary Artery Disease: Current Evidence and Future Perspectives

edited by Tadateru Takayama

submission deadline 30 Nov 2025 | Viewed by 202 | Submission Open

Keywords: coronary artery disease; lipid-lowering therapy; residual risk; small dense LDL; lipoprotein(a); endothelial dysfunction; oxidative stress; inflammation; biomarkers; cardiovascular prevention

(This special issue belongs to the Section Molecular and Translational Medicine)

Urogenital Cancers: New Molecular and Translational Aspects on Carcinogenesis and Treatments (2nd Edition)

edited by

Silvia Di Agostino

Vittoria Rago

and

Anna Perri

submission deadline 30 Nov 2025 | Viewed by 198 | Submission Open

Keywords: prostate cancer; bladder cancer; renal cell carcinoma; testicular cancer; ovarian cancer; endometrial cancer; carcinogenesis; biomarkers; early diagnosis; upper urinary tract tumors; diagnosis; treatment; environmental factors; diet

(This special issue belongs to the Section Cancer Biology and Oncology)

Mitochondrion-Targeting Agents for Tumor Therapy

edited by

Menghuan Tang

submission deadline 30 Nov 2025 | Viewed by 190 | Submission Open

Keywords: mitochondria; cell signaling; apoptosis; cancer therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Novel Biomaterials and Tissue Engineering Approaches in Periodontal Regeneration

edited by

Federico Mussano

submission deadline 30 Nov 2025 | Viewed by 177 | Submission Open

Keywords: periodontium; tissue engineering; regenerative medicine; biomaterials; bioprinting; mesenchymal stem/stromal cells; senescence; aging; advanced therapeutics

(This special issue belongs to the Section Biomedical Engineering and Materials)

Pathogenesis, Diagnosis, and Treatment of Prostate Cancer

edited by

Sara Harsini

submission deadline 30 Nov 2025 | Viewed by 171 | Submission Open

Keywords: prostate cancer ; molecular imaging; PET/CT; PSMA (prostate-specific membrane antigen); theranostics; radiopharmaceutical therapy; diagnosis and staging; radiology; targeted therapy; tumor microenvironment

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in the Pathogenesis and Treatment of Acute Myeloid Leukemia—2nd Edition

edited by

Alessandra Sperotto

submission deadline 30 Nov 2025 | Viewed by 159 | Submission Open

Keywords: acute myeloid leukemia; target therapies; molecular pathogenesis; biological therapy; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Gut Microbiota and Cancers of the GI Tract: Role in Regulation, Prevention and Therapy

edited by Luka Bočkor and

Jurica Žučko

submission deadline 30 Nov 2025 | Viewed by 156 | Submission Open

Keywords: gut microbiota; gastrointestinal cancers; gastrointestinal microbiota; anti-cancer therapies

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Engineering Extracellular Matrix (ECM)-Based Scaffold Biomaterials for Cancer Treatment

edited by

Sanjay Pal

submission deadline 30 Nov 2025 | Viewed by 155 | Submission Open

Keywords: extracellular matrix; biomaterials; immunomodulatory agents; cancer immunotherapy; sustained delivery; drug delivery; tumor modeling; 3D model; therapeutic response; decellularized ECM

(This special issue belongs to the Section Gene and Cell Therapy)

Clinical Advances in Hepatocellular Carcinoma

edited by Mohamed A. Abd El Aziz

submission deadline 30 Nov 2025 | Viewed by 153 | Submission Open

Keywords: hepatocellular cancer; liver cirrhosis; chemotherapy; immunotherapy; radiofrequency ablation; microwave ablation

(This special issue belongs to the Section Cancer Biology and Oncology)

Small Intestinal Bacterial Overgrowth and Antimicrobial

edited by

Andrej Belančić

and

Mislav Radić

submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open

Keywords: small intestine bacterial overgrowth; antibiotics; probiotics; gut microbiome

(This special issue belongs to the Section Molecular and Translational Medicine)

The Preparation of an Exosome/Liposomal Nano-Drug Delivery System and Its Application in the Treatment of Inflammatory Bowel Disease

edited by

Dingpei Long

and

Jialing Bao

submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open

Keywords: exosomes; liposomes; nano-drug delivery systems; inflammatory bowel disease (IBD); targeted therapy; mucosal drug delivery; drug encapsulation; immunomodulation; nanomedicine; extracellular vesicles; personalized medicine

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Pharmacology of Pain and Inflammation

edited by Fernanda Regina de Castro Almeida and Francisco De Assis Oliveira

submission deadline 30 Nov 2025 | Viewed by 143 | Submission Open

Keywords: natural products; chronic pain; neuropathies; oncological pain; anti-inﬂammatory activity; pulmonary emphysema

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Innovative Therapies for Neurodegenerative Diseases

edited by

Rosa María Giráldez-Pérez

, María Victoria Naval,

Javier Garcia-Pardo

and

Maria João Ramalho

submission deadline 30 Nov 2025 | Viewed by 139 | Submission Open

Keywords: nanotechnology-based therapies; cellular and regenerative therapies; stem cell therapy; gene therapy and RNA interference; protein aggregation inhibitors; neuroinflammation modulators; mitochondrial dysfunction-targeted drugs; preclinical and clinical trials

(This special issue belongs to the Section Gene and Cell Therapy)

Basic and Clinical Research of Psychiatric Diseases

edited by

Anita Kovács

submission deadline 30 Nov 2025 | Viewed by 130 | Submission Open

Keywords: psychiatric diseases; anxiety disorder; PTSD; schizophrenia; Alzheimer’ s disease; autism spectrum disorder; depression

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Congenital Heart Disease (CHD)

edited by Paul Philipp Heinisch

submission deadline 30 Nov 2025 | Viewed by 127 | Submission Open

Keywords: congenital heart disease (CHD); biomaterials; imaging modalities

(This special issue belongs to the Section Molecular and Translational Medicine)

Structure-Based Drug Molecule Design and Organic Synthesis

edited by

Sateesh Dubbu

submission deadline 30 Nov 2025 | Viewed by 126 | Submission Open

Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Mechanisms of Cellular Senescence and Inflammation in Cardiovascular Disease

edited by Sivareddy Kotla

submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open

Keywords: cellular senescence; inflammation; cardiovascular disease

(This special issue belongs to the Section Cell Biology and Pathology)

Nanoparticles and Biomaterials: Pioneering Innovations in Biomedical Device Engineering

edited by Eleni Papachristou

submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open

Keywords: nanoparticle NPs; biomaterials; drug delivery; mRNA delivery; antimicrobial activity; cancer; tissue regeneration; differentiation

(This special issue belongs to the Section Nanomedicine and Nanobiology)

From Cell Dysfunction to Prothrombotic Disorders: Molecular Pathways and Clinical Implications

edited by

Cristina Barale

submission deadline 30 Nov 2025 | Viewed by 123 | Submission Open

Keywords: prothrombotic disorder; cellular dysfunction; hemostatic balance; thrombosis; novel biomarkers; antithrombotic therapies

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Medically Assisted Reproduction

edited by

Theodoros Kalampokas

submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open

Keywords: infertility; medically assisted reproduction; reproductive endocrinology; clinical embryology; genetics; artificial intelligence; epigenetics; precision medicine; evidence-based medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Immunological Avalanches: Understanding Immune System Instability in Lupus, IgA Nephropathy, and Transplant Rejection

edited by

Davide Viggiano

, Giuseppe Gigliotti and Angelo Ferrantelli

submission deadline 30 Nov 2025 | Viewed by 102 | Submission Open

Keywords: immunological avalanche; lupus nephritis; IgA nephropathy; transplant rejection; complement dysregulation

(This special issue belongs to the Section Immunology and Immunotherapy)

Activation and Regulation of NLRP3 Inflammasome

edited by

Wei Guo

submission deadline 30 Nov 2025 | Viewed by 98 | Submission Open

Keywords: NLRP3 inflammasome; innate immunity; inflammation; pyroptosis; caspase-1; IL-1β ; IL-18; DAMPs; PAMPs; inflammasome inhibitors; post-translational modifications; chronic inflammatory diseases; metabolic disorders; neurodegenerative diseases; therapeutic targeting

(This special issue belongs to the Section Molecular and Translational Medicine)

Human Dental Stem Cells: The Last 25 Years

edited by

Christian Morsczeck

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: dental stem cells; regenerative dentistry; differentiation; periodontitis

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in the Molecular Biology of Transplantation

edited by Anil S. Paramesh

submission deadline 30 Nov 2025 | Viewed by 89 | Submission Open

Keywords: donor-derived cell-free DNA; Torque Teno Virus monitoring; gene expression profiling; kidney/pancreas transplants

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Human Immunodeficiency Virus (HIV): Past, Present and Future

edited by

Ana Borrajo

submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open

Keywords: HIV latency; ART; HIV reservoirs; NeuroHIV; immune activation; HIV cure strategies; virus– host interactions; HIV comorbidities; HIV and ageing; translational HIV research

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Fabry Disease: From Molecular Insights to Innovative Therapeutics

edited by

Yuri Battaglia

and Concetto Sessa

submission deadline 10 Dec 2025 | 8 articles | Viewed by 15738 | Submission Open

Keywords: fabry disease; lysosomal storage disorder; GLA gene mutations; enzyme replacement therapy; chaperone therapy; physical activity; imagining

(This special issue belongs to the Section Molecular and Translational Medicine)

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