Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Spinal Muscular Atrophy: Pathogenesis, Diagnosis, Therapeutics and Future Directions
edited by , and Valentino Rački
submission deadline 15 Nov 2025 | 1 articles | Viewed by 2249 | Submission Open
Keywords: genetic diseases; neuromuscular disorders; rare diseases; spinal muscular atrophy; survival motor neuron protein
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
“The Power of Light” in Biomedical and Pharmaceutics: New Approaches for Photodynamic Purposes submission deadline 20 Nov 2025 | Viewed by 203 | Submission Open
Keywords: light; photosensitizers; photochemistry; photobiology; photodynamic therapy
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Head and Neck Cancer submission deadline 29 Nov 2025 | 3 articles | Viewed by 5981 | Submission Open
Keywords: modern therapeutic approach; nasopharyngeal carcinoma; head and neck cancer; particle therapy; cancer survivorship; sinonasal cancer
(This special issue belongs to the Section Molecular and Translational Medicine)
The End of the COVID-19 Pandemic—What Is Currently Known and What Could Have Been Useful Four Years Ago? (2nd Edition) submission deadline 30 Nov 2025 | 18 articles | Viewed by 44947 | Submission Open
Keywords: COVID-19; SARS-CoV-2; pandemic; diagnosis; biomarkers; treatment; immunity; inflammation; cytokines; vaccine
(This special issue belongs to the Section Molecular and Translational Medicine)
Dopamine Signaling Pathway in Health and Disease—2nd Edition submission deadline 30 Nov 2025 | 9 articles | Viewed by 27092 | Submission Open
Keywords: differentiation; disease modeling  ; dopamine and drugs; gene expression; human stem cells; neuronal development; reprogramming; signaling pathways; neurodegeneration; neuromodulation
(This special issue belongs to the Section Molecular and Translational Medicine)
Progress in Neurodevelopmental Disorders Research submission deadline 30 Nov 2025 | 6 articles | Viewed by 23978 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder; attention deficit hyperactivity disorder
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 2nd Edition submission deadline 30 Nov 2025 | 6 articles | Viewed by 21077 | Submission Open
Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Acute and Chronic Heart Failure: Pathophysiology and New Therapeutic Developments, 2nd Edition
edited by and Valentina Mercurio
submission deadline 30 Nov 2025 | 15 articles | Viewed by 20340 | Submission Open
Keywords: heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; pathophysiological novelties; treatment advances; pulmonary arterial hypertension; at-home follow-up of patients with heart failure
(This special issue belongs to the Section Molecular and Translational Medicine)
Women’s Special Issue Series: Biomedicines (2nd Edition) submission deadline 30 Nov 2025 | 6 articles | Viewed by 18098 | Submission Open
Keywords: antibody; biomedicines; biopharmaceutical products; cancer therapy; drug delivery; immunoconjugates; immunotoxins; immunotherapy; immunotargeting; nanodelivery; toxins
(This special issue belongs to the Section Molecular and Translational Medicine)
Feature Reviews on Cardiovascular and Metabolic Diseases
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 12964 | Submission Open
Keywords: cardiovascular diseases; metabolic diseases; global health; disease prevention; innovative treatments
(This special issue belongs to the Section Cell Biology and Pathology)
The Neuropharmacology of Cannabinoids: Developments in Medicine
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 12795 | Submission Open
Keywords: THC; CBD; cannabis; endocannabinoid system; therapeutic; disease; health
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Neonatal Disease: From Pathophysiology to Current and Emerging Therapeutic Approaches (2nd Edition)
edited by
submission deadline 30 Nov 2025 | 8 articles | Viewed by 12381 | Submission Open
Keywords: fetal therapy; neonatal diseases; pathophysiology; innovative therapeutic approaches
(This special issue belongs to the Section Cell Biology and Pathology)
Ovarian Physiology and Reproduction
edited by Atefeh Najafi
submission deadline 30 Nov 2025 | 5 articles | Viewed by 10078 | Submission Open
Keywords: ovarian physiology; female fertility; folliculogenesis; oocyte; hormonal regulation; endocrine disruptors; ovarian aging; genetic modifications; environmental factors and female fertility; female reproductive health and disorders
(This special issue belongs to the Section Molecular and Translational Medicine)
The Development of Cancer Immunotherapy
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 9927 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors
(This special issue belongs to the Section Cancer Biology and Oncology)
Wound Healing: From Mechanisms to Therapeutic Approaches
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 9573 | Submission Open
Keywords: wound healing; acute wounds; chronic wounds; keloids; hypertrophic scar; therapies; photobiomodulation; neuroimmunomodulation
(This special issue belongs to the Section Molecular and Translational Medicine)
New Insights into Bone and Cartilage Biology
edited by Vincent Yuan
submission deadline 30 Nov 2025 | 5 articles | Viewed by 9435 | Submission Open
Keywords: bone remodeling; cartilage degeneration; osteoporosis; osteoarthritis; mitochondrial function; protein modifications; immune signaling; therapeutic strategies
(This special issue belongs to the Section Molecular and Translational Medicine)
Emerging Trends in Gastrointestinal Tract Disease Therapies
edited by , Jenwei Chou and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 8610 | Submission Open
Keywords: gut microbiota; fecal microbiota transplantation; inflammatory bowel disease; advanced endoscopy; endoscopic bariatric therapy; endoscopic anti-reflux therapy natural orifice transluminal endoscopic surgery; artificial intelligence
(This special issue belongs to the Section Molecular and Translational Medicine)
Extracellular Vesicles for Diagnosis and Treatment of Human Diseases
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 8216 | Submission Open
Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology
(This special issue belongs to the Section Molecular and Translational Medicine)
New Insights and Latest Advances in Corneal and Ocular Surface Diseases
edited by Isabella M. Y. Cheung and Akilesh Gokul
submission deadline 30 Nov 2025 | 6 articles | Viewed by 7638 | Submission Open
Keywords: corneal disease; ocular surface disease prevention; diagnosis; management; pathobiology; epidemiology; health service delivery
(This special issue belongs to the Section Molecular and Translational Medicine)
Tendinopathy and Myopathy: From Molecular Basis to Therapy
edited by and Carl Pai Chu Chen
submission deadline 30 Nov 2025 | 2 articles | Viewed by 7058 | Submission Open
Keywords: musculoskeletal disorder; tendinopathy; myopathy
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research on Genitourinary Cancer
edited by Jue Wang
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6768 | Submission Open
Keywords: genitourinary (GU) cancer; prostate; bladder; kidney; and testicular cancer; diagnosis; treatment; pathogenesis; precision medicine; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular and Translational Medicine)
Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches submission deadline 30 Nov 2025 | 3 articles | Viewed by 6664 | Submission Open
Keywords: colorectal cancer; biomarkers; chemotherapy; immunotherapy; liquid biopsy; endoscopy; surgery; microbiota; screening
(This special issue belongs to the Section Cancer Biology and Oncology)
Neuroinflammation and Neuroprotection
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6456 | Submission Open
Keywords: neuroinflammation; neurodegeneration; mechanisms; disease progression; ER stress; oxidative stress; mitochondrial dysfunction
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Novel Insights into Liver Metabolism submission deadline 30 Nov 2025 | 4 articles | Viewed by 6417 | Submission Open
Keywords: liver; metabolism; oxidative stress; mi-RNAs; cirrhosis; alcohol-related liver disease; autoimmune liver disorders; hepatocellular cancer; liver steatosis; microbiota; diagnostic markers
(This special issue belongs to the Section Endocrinology and Metabolism Research)
From Bench to Bedside: Advances in Non-small Cell Lung Cancer in the Era of Precision Oncology
edited by Iyare Izevbaye
submission deadline 30 Nov 2025 | 2 articles | Viewed by 5855 | Submission Open
Keywords: non-small-cell lung cancer; precision medicine; liquid biopsy; biomarkers; predictive modeling; comprehensive genomic profiling; biomarkers; immuno-oncology; lung cancer biology
(This special issue belongs to the Section Cancer Biology and Oncology)
Connections Between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies—Second Edition
edited by and Dragos Cozma
submission deadline 30 Nov 2025 | 7 articles | Viewed by 5500 | Submission Open
Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; thyroid dysfunction; hormonal alterations; endothelial dysfunction; coronary artery disease; hypertension; peripheric arterial disease
(This special issue belongs to the Section Endocrinology and Metabolism Research)
The Art of ART (Assisted Reproductive Technologies) submission deadline 30 Nov 2025 | 4 articles | Viewed by 5023 | Submission Open
Keywords: assisted reproductive technologies; infertility diagnosis; intrauterine insemination (IUI); intracytoplasmic sperm injection (ICSI); in vitro fertilization (IVF); embryo implantation; oocyte quality; preimplantation genetic testing; mitochondrial replacement therapy; follicular recruitment; reproductive medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Bioinformatics Analysis of RNA for Human Health and Disease
edited by Jihwan Ha
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4971 | Submission Open
Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g.; m6A; pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Mechanisms and Therapeutic Strategies of Brain and Spinal Cord Injury
edited by and Xabier Urra
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4930 | Submission Open
Keywords: brain injury; spinal cord injury; stem cells; gene therapy; neuromodulation techniques
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4773 | Submission Open
Keywords: skin diseases; cell death; ferroptosis; cuproptosis; melanoma; cancer immunotherapy; psoriasis
(This special issue belongs to the Section Molecular and Translational Medicine)
Animal Models of Neurological Disorders: Where Are We Now? (3rd Edition)
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4698 | Submission Open
Keywords: animal model of neurological disorders; Parkinson’ s disease; Alzheimer’ s disease; epilepsy; seizures; Huntington’ s disease; schizophrenia
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Diagnostics and Therapy for Malignant Tumors: New Developments
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 4603 | Submission Open
Keywords: metabolites; immunity; microbiome; microenvironment; inflammation
(This special issue belongs to the Section Cancer Biology and Oncology)
Neurodegeneration No More: Cutting-Edge Technologies and Therapies in the Evolution of Neurodegenerative Disease Management—2nd Edition submission deadline 30 Nov 2025 | 5 articles | Viewed by 4270 | Submission Open
Keywords: Alzheimer’ s disease; frontotemporal lobar degeneration; Parkinson’ s disease; aging decline; mild cognitive impairment; multiple sclerosis; stroke; acquired brain damage; altered cognitive processes; brain functional impairment; neurocognitive disorders; cognitive; behavioral; and functional disorders; acquired trauma; brain plasticity and connectivity; non-invasive brain stimulation; diagnosis and treatment; functional evidence of altered cognition and connectivity; blood-based biomarkers; disease heterogeneity; prognosis; protein aggregation; inflammation; oxidative stress; medicinal plants; phytocompounds
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Animal Models for Neurological Disease Research
edited by
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4142 | Submission Open
Keywords: animal models; neurological diseases; genetic models; CRISPR/Cas9; transgenic organisms; behavioral analysis; neurodegeneration; single-cell approaches; zebrafish; lamprey; biocomputational approaches; gene therapy; pharmacological interventions; translational neurobiology; disease pathways
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Reproductive Endocrinology and Fertility: From Bench to Bedside
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 4075 | Submission Open
Keywords: reproductive health; reproductive system diseases; hormonal regulation; infertility; reproductive dysfunction; reproductive genetics; reproductive physiology; assisted reproductive technologies
(This special issue belongs to the Section Molecular and Translational Medicine)
Bench-to-Bedside Approach to Migraine: How Pathophysiology Could Influence Novel Therapeutic Approaches and Back
edited by Alessandro Vigano and Matteo Castaldo
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4073 | Submission Open
Keywords: migraine; comorbidities; pathophysiology; pharmacological interventions; non-pharmacological interventions; chronicization; neurophysiological or neuroimaging for disability or clinical response
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Genomics and Bioinformatics of Human Disease submission deadline 30 Nov 2025 | 2 articles | Viewed by 3853 | Submission Open
Keywords: genomics; bioinformatics; precision medicine; single-cell RNA sequencing; genetic variations; cellular heterogeneity; AI/ML; pathogenicity prediction
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Brain Tumor Diagnosis: Innovations and Emerging Technologies submission deadline 30 Nov 2025 | 3 articles | Viewed by 3430 | Submission Open
Keywords: brain tumor diagnosis; artificial intelligence in oncology; deep learning in medical imaging; machine learning models; predictive analytics in healthcare; digital pathology; glioma detection; multi-modal data integration; neuro-oncology; precision medicine
(This special issue belongs to the Section Cancer Biology and Oncology)
Exploring Human Diseases Through Genomic and Genetic Analyses
edited by Fernando Regateiro and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3417 | Submission Open
Keywords: genomic and genetic analyses; genomic medicine; personalized medicine; technologies and testing methods; complex diseases; monogenic diseases; pharmacogenomics
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Advanced Research in Pulmonary Pathophysiology
edited by Ourania S. Kotsiou and Erasmia Rouka
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3295 | Submission Open
Keywords: pathophysiology; aging; disease; injury; microbiome; small airways; pleura; lung cancer; infections; critical care
(This special issue belongs to the Section Cell Biology and Pathology)
The Role of Iron in Human Diseases
edited by Margherita Correnti
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3207 | Submission Open
Keywords: iron metabolism; iron dysregulation; diseases; iron deficiency; iron overload
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Periodontal Disease and Periodontal Tissue Regeneration—Second Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 3109 | Submission Open
Keywords: periodontal diagnosis; periodontal immunology; periodontal microbiology; periodontal tissue regeneration; tissue engineering
(This special issue belongs to the Section Biomedical Engineering and Materials)
Role of Natural Product in Cardiovascular Disease—2nd Edition
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2897 | Submission Open
Keywords: nature products; phytochemicals; biological and pharmacological activity; cardiovascular disease (CVD) pathogenesis of CVD; risk factors of CVD; metabolic symptom; clinical or preclinical studies
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Pediatric Tumors: Diagnosis, Pathogenesis, Treatment, and Outcome
edited by Hermann L. Müller
submission deadline 30 Nov 2025 | 4 articles | Viewed by 2808 | Submission Open
Keywords: pediatric oncology; leukemia; sarcoma; brain tumor; chemotherapy; irradiation; targeted therapy; sequelae
(This special issue belongs to the Section Cancer Biology and Oncology)
Coronary Artery Disease: From Pathophysiology to Therapeutic Strategies submission deadline 30 Nov 2025 | 2 articles | Viewed by 2720 | Submission Open
Keywords: pathophysiological concept of coronary artery disease; coronary microvascular dysfunction; chronic coronary syndrome; acute coronary syndrome; post-acute coronary syndrome with heart failure; diagnostics in coronary artery disease; therapeutic strategies in CAD; revascularization
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in the Pathogenesis and Treatment of Heart Failure and Cardiomyopathy
edited by , Ednei Luiz Antonio, Gianna Móes de Albuquerque-Pontes and Luis Felipe Neves dos Santos
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2636 | Submission Open
Keywords: cardiomyopathy; cardiac remodeling; heart disease; heart failure; mechanisms; new therapies; targeted therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Thoracic Malignancies: From Pathophysiology to Novel Therapeutic Approaches
edited by Yanyun Gao
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2625 | Submission Open
Keywords: thoracic malignancies; lung cancer; esophageal cancer; pleural mesothelioma (PM); molecular subtypes; drug resistance; target therapy; biomarkers; immunotherapy; preclinical models
(This special issue belongs to the Section Cancer Biology and Oncology)
Two Decades of Advances in Colorectal Cancer Prevention and Treatment: From Aspirin to Precision Oncology
edited by and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2399 | Submission Open
Keywords: immunotherapy; biomarkers; colorectal cancer; targeted therapies; molecular pathways
(This special issue belongs to the Section Cancer Biology and Oncology)
Inflammatory Bowel Diseases: New Diagnostic and Therapeutic Approaches—Second Edition submission deadline 30 Nov 2025 | 1 articles | Viewed by 2084 | Submission Open
Keywords: bowel inflammation; Crohn’ s disease; endoscopy; inflammatory bowel disease; targeted therapy; ulcerative colitis
(This special issue belongs to the Section Immunology and Immunotherapy)
Non-Invasive Brain Stimulation Techniques and Their Application in the Study of Cognitive Function Physiology and Neuro-Psychiatric Rehabilitation
edited by , and Andrea Stefano Moro
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2072 | Submission Open
Keywords: non-invasive brain stimulation; neurophysiology; cognitive function; depression; schizophrenia  
(This special issue belongs to the Section Molecular and Translational Medicine)
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