Glaucoma: The Mechanisms and Novel Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 16
Special Issue Editor
2. Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China
3. Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China
Interests: autophagy; intraocular pressure; ocular hypertension; outflow facility; gene-editing; DNA methylation; small RNAs
Special Issue Information
Dear Colleagues,
Glaucoma remains a leading cause of irreversible blindness worldwide, primarily driven by elevated intraocular pressure and impaired aqueous humor outflow. Recent advances in molecular biology have revealed critical roles for autophagy, epigenetic regulation, and non-coding RNAs in maintaining ocular homeostasis and modulating disease progression.
This Special Issue will focus on the molecular and physiological mechanisms underlying ocular pressure regulation and their implications for glaucoma and related disorders. We invite authors to submit contributions that explore autophagy, intraocular pressure (IOP) dynamics, ocular hypertension, and aqueous humor outflow facility. Studies leveraging advanced gene-editing technologies, epigenetic modifications such as DNA methylation, and the role of small RNAs in ocular health and disease are particularly encouraged. Both experimental and translational studies addressing therapeutic targets and innovative interventions are welcome.
Topics of Interest
- Gene-editing approaches for glaucoma therapy (e.g., CRISPR/Cas systems).
- Epigenetic modifications in glaucoma.
- Role of small RNAs in IOP regulation and neuroprotection.
- Novel biomarkers for glaucoma diagnosis and progression monitoring.
- Translational studies targeting outflow facility and neuroprotection.
- Therapeutic strategies integrating molecular and physiological insights.
Dr. Samantha Sze Wan Shan
Guest Editor
Manuscript Submission Information
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Keywords
- intraocular pressure
- ocular hypertension
- outflow facility
- gene-editing
- epigenetic modifications
- small RNAs
- translational studies
- biomarkers
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