Periodontal Disease and Periodontal Tissue Regeneration—Second Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 75

Special Issue Editors


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Department of Periodontology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania
Interests: periodontitis etiopathogeny; periodontal medicine; periodontal surgery; periodontal adjunctive treatment
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Odontology-Periodontology and Fixed Prosthodontics Department, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: periodontal risk factors; periodontal non-surgical therapy; periodontal surgical therapy; periodontal adjunctive treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We cordially extend an invitation for you to submit a manuscript for our forthcoming Special Issue on “Periodontal Disease and Periodontal Tissue Regeneration—Second Edition”.

Further clarification is needed regarding the onset and evolutionary mechanisms of periodontal disease to ensure appropriate treatment. It is imperative that there is a clear understanding of the underlying causes and factors contributing to the disease. This understanding will facilitate the development of effective treatment plans tailored to individual patients’ needs, ultimately improving patient outcomes.

Advancing our understanding of periodontal tissue regeneration is imperative to enhance the quality of life for patients affected by periodontal diseases. Innovations in periodontal tissue engineering hold the promise of revolutionizing dental healthcare, emphasizing the urgency of ongoing research.

All review articles, research articles, and techniques on advanced technologies and methods for periodontal diagnosis and the surgical approach for periodontal tissue regeneration are of interest to this Special Issue. Your contribution to this topic would be greatly appreciated and could potentially provide valuable insights into this area of research. We look forward to receiving your submission and are confident that your work will be of great interest to our readers.

Dr. Irina-Georgeta Sufaru
Prof. Dr. Sorina Mihaela Solomon
Guest Editors

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Keywords

  • periodontal diagnosis
  • periodontal immunology
  • periodontal microbiology
  • periodontal tissue regeneration
  • tissue engineering

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Published Papers (1 paper)

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Review

15 pages, 452 KiB  
Review
More than Just a Toothache: Inflammatory Mechanisms Linking Periodontal Disease to Cardiovascular Disease and the Protective Impact of Cardiorespiratory Fitness
by Michael F. Mendoza, Michael A. Anzelmo, Nina M. Suan, Chloe S. Cuccia and Carl J. Lavie
Biomedicines 2025, 13(7), 1512; https://doi.org/10.3390/biomedicines13071512 - 20 Jun 2025
Abstract
Periodontal disease is a chronic inflammatory condition that extends beyond the oral cavity and is increasingly recognized as a significant contributor to cardiovascular disease, the leading cause of global mortality. Systemic inflammation serves as the key link between the two, with elevated biomarkers [...] Read more.
Periodontal disease is a chronic inflammatory condition that extends beyond the oral cavity and is increasingly recognized as a significant contributor to cardiovascular disease, the leading cause of global mortality. Systemic inflammation serves as the key link between the two, with elevated biomarkers such as C-reactive protein and interleukin-6 observed in individuals with PD, driving endothelial dysfunction and atherogenesis. Epidemiological and mechanistic studies consistently demonstrate that PD not only heightens the risk of major adverse cardiovascular events but is also independently associated with increased all-cause and cardiovascular mortality. In parallel, emerging research underscores the protective role of regular physical activity and improved cardiorespiratory fitness, which attenuate systemic inflammation and may reduce the burden of both PD and CVD. This review integrates current evidence on the shared inflammatory mechanisms linking PD and CVD, highlights the systemic impact of poor oral health, and advocates for incorporating exercise-based interventions and oral health assessments into comprehensive cardiovascular risk management. A multidisciplinary approach—bridging cardiology, dentistry, and preventive medicine—may offer a novel strategy to reduce inflammation-driven morbidity and mortality. Full article
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