Immunometabolism in Disease Development
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 September 2026
Special Issue Editors
Interests: bioactive compounds; immunometabolism; nutritional immunology; NAFLD; hepatocellular carcinoma; metabolic disorders; gut–liver axis; inflammation; preclinical models; functional foods; nutritional interventions
Interests: immunonutrition; innate immunity; macrophage; bioenergetics; hepatoblastoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunometabolism, the dynamic interplay between metabolic pathways and immune cell function, has emerged as a pivotal regulatory axis in health and disease. It is now evident that metabolic reprogramming not only supports the bioenergetic and biosynthetic demands of immune cells but also directly governs their differentiation, activation, and effector functions. In particular, the understanding of how immune cells alter their metabolism during inflammation, cancer, infection, and autoimmune diseases has profound implications for both basic science and therapeutic interventions.
This Special Issue, Immunometabolism in Disease Development, seeks to highlight the crucial role of metabolic pathways in immune system function and how dysregulation in these pathways can contribute to disease pathogenesis. Key objectives include the following:
- Exploring how immune cells (e.g., T cells, macrophages, dendritic cells) undergo metabolic shifts in response to infection, inflammation, or cancer.
- Identifying new therapeutic approaches based on targeting metabolic pathways in immune cells for disease intervention.
- Studies exploring specific molecules and signaling pathways that link metabolism and immune function, including key metabolic enzymes, metabolites, and transcription factors.
- Analyzing how metabolic disorders impact immune function and exacerbate chronic inflammation.
We look forward to receiving your contributions to this integrative exploration of immunometabolism, a field poised to redefine our understanding of disease mechanisms and open new avenues for immune-modulating therapies.
Dr. Aurora Garcia Tejedor
Dr. Jose Moisés Laparra
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- immunometabolism
- metabolic reprogramming
- cancer immunometabolism
- metabolic checkpoints
- therapeutic targeting
- chronic inflammation
- signaling pathways
- gut–liver–brain
- bioenergetics
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