Neuroinflammation: From Mechanisms to Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 July 2026
Special Issue Editor
Interests: bioinformatics; computational biology; artificial intelligence; brain development and disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroinflammation is now widely appreciated as a core, mechanistically informative feature of many CNS disorders, including neurodegenerative diseases, demyelinating conditions, stroke and traumatic injury, infection, and selected neuropsychiatric syndromes. Importantly, inflammatory programs in the brain are not simply downstream consequences of pathology; they can shape synaptic remodeling, neuronal vulnerability, and blood–brain barrier function through dynamic interactions among microglia, astrocytes, neurons, peripheral immune cells, and the neurovascular unit. As tools such as single-cell and spatial profiling, advanced imaging, and human genetics refine our view of inflammatory states, the field is poised to move from descriptive associations toward actionable, disease-stage-specific interventions.
This Special Issue, “Neuroinflammation: From Mechanisms to Therapeutic Approaches,” welcomes original research and authoritative reviews that bridge fundamental mechanisms with translational impact. We invite submissions addressing, for example, glial state regulation; cytokine/chemokine and complement signaling; inflammasomes, immunometabolism, and oxidative stress; neuroimmune-synaptic and neurovascular crosstalk; BBB dysfunction and systemic immune influences; biomarkers and imaging (CSF/plasma, PET, multi-omics signatures); and therapeutic strategies including anti-inflammatory and immunomodulatory agents, biologics, gene/RNA-based approaches, pro-resolving mediators, microbiome-directed interventions, and regenerative cell or cell-free therapies. By bringing together diverse experimental and clinical viewpoints, this Special Issue seeks to clarify convergent inflammatory mechanisms, highlight emerging therapeutic opportunities, and accelerate translation from discovery to patient benefit.
Dr. Yuen Gao
Guest Editor
Manuscript Submission Information
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Keywords
- neuroinflammation
- molecular mechanism
- cell-free stem-cell-based therapy
- anti-inflammation
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