Macrophages and Immune Modulation in Cancer Therapy

Dear Colleagues,

This Special Issue focuses on the pivotal and multifaceted roles of macrophages in cancer, highlighting recent advances in macrophage heterogeneity, lineage plasticity, and functional reprogramming.

Macrophages are not merely participants but central orchestrators of the tumor immune microenvironment. As one of the most abundant and functionally dominant immune cell populations in solid tumors, they exert profound influence over cancer progression, immune suppression, stromal remodeling, angiogenesis, and therapeutic resistance. Their exceptional plasticity enables them to transition between tumor-promoting and tumor-restraining states, making them indispensable determinants of disease trajectory and highly promising targets for next-generation cancer immunotherapies.

We welcome studies investigating macrophage–tumor and macrophage–stromal interactions, molecular mechanisms of immune modulation, and macrophage-based therapeutic strategies. Submissions focusing on macrophage reprogramming, targeted signaling pathways, or innovative immunotherapy approaches are also encouraged. Original research, reviews, and translational studies that deepen mechanistic understanding or propose macrophage-targeted treatments are particularly welcome.

Dr. Max Kam-Kwan Chan
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.