Macrophages and Immune Modulation in Cancer Therapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 965
Special Issue Editor
Interests: tumor immunology and macrophage biology; tumor microenvironment and immune modulation; cancer signaling and stromal–immune crosstalk; translational oncology and therapeutic targeting of myeloid cells
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the pivotal and multifaceted roles of macrophages in cancer, highlighting recent advances in macrophage heterogeneity, lineage plasticity, and functional reprogramming.
Macrophages are not merely participants but central orchestrators of the tumor immune microenvironment. As one of the most abundant and functionally dominant immune cell populations in solid tumors, they exert profound influence over cancer progression, immune suppression, stromal remodeling, angiogenesis, and therapeutic resistance. Their exceptional plasticity enables them to transition between tumor-promoting and tumor-restraining states, making them indispensable determinants of disease trajectory and highly promising targets for next-generation cancer immunotherapies.
We welcome studies investigating macrophage–tumor and macrophage–stromal interactions, molecular mechanisms of immune modulation, and macrophage-based therapeutic strategies. Submissions focusing on macrophage reprogramming, targeted signaling pathways, or innovative immunotherapy approaches are also encouraged. Original research, reviews, and translational studies that deepen mechanistic understanding or propose macrophage-targeted treatments are particularly welcome.
Dr. Max Kam-Kwan Chan
Guest Editor
Manuscript Submission Information
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Keywords
- tumor-associated macrophages
- macrophage plasticity
- macrophage reprogramming
- immune modulation
- macrophage-targeted therapies
- macrophage–stromal interactions
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