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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Therapies for Neurodegenerative Diseases

edited by

Rosa María Giráldez-Pérez

, María Victoria Naval,

Javier Garcia-Pardo

and

Maria João Ramalho

submission deadline 30 Nov 2025 | Viewed by 113 | Submission Open

Keywords: nanotechnology-based therapies; cellular and regenerative therapies; stem cell therapy; gene therapy and RNA interference; protein aggregation inhibitors; neuroinflammation modulators; mitochondrial dysfunction-targeted drugs; preclinical and clinical trials

(This special issue belongs to the Section Gene and Cell Therapy)

From Cell Dysfunction to Prothrombotic Disorders: Molecular Pathways and Clinical Implications

edited by

Cristina Barale

submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open

Keywords: prothrombotic disorder; cellular dysfunction; hemostatic balance; thrombosis; novel biomarkers; antithrombotic therapies

(This special issue belongs to the Section Cell Biology and Pathology)

Nanoparticles and Biomaterials: Pioneering Innovations in Biomedical Device Engineering

edited by Eleni Papachristou

submission deadline 30 Nov 2025 | Viewed by 109 | Submission Open

Keywords: nanoparticle NPs; biomaterials; drug delivery; mRNA delivery; antimicrobial activity; cancer; tissue regeneration; differentiation

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Basic and Clinical Research of Psychiatric Diseases

edited by

Anita Kovács

submission deadline 30 Nov 2025 | Viewed by 109 | Submission Open

Keywords: psychiatric diseases; anxiety disorder; PTSD; schizophrenia; Alzheimer’ s disease; autism spectrum disorder; depression

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research in Congenital Heart Disease (CHD)

edited by Paul Philipp Heinisch

submission deadline 30 Nov 2025 | Viewed by 107 | Submission Open

Keywords: congenital heart disease (CHD); biomaterials; imaging modalities

(This special issue belongs to the Section Molecular and Translational Medicine)

Structure-Based Drug Molecule Design and Organic Synthesis

edited by

Sateesh Dubbu

submission deadline 30 Nov 2025 | Viewed by 105 | Submission Open

Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Pharmacology of Pain and Inflammation

edited by Fernanda Regina de Castro Almeida and Francisco De Assis Oliveira

submission deadline 30 Nov 2025 | Viewed by 104 | Submission Open

Keywords: natural products; chronic pain; neuropathies; oncological pain; anti-inﬂammatory activity; pulmonary emphysema

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Mechanisms of Cellular Senescence and Inflammation in Cardiovascular Disease

edited by Sivareddy Kotla

submission deadline 30 Nov 2025 | Viewed by 100 | Submission Open

Keywords: cellular senescence; inflammation; cardiovascular disease

(This special issue belongs to the Section Cell Biology and Pathology)

Advancing Pharmacogenetics and Pharmacogenomics in Pre-Clinical Research: Unveiling New Avenues for Precision Medicine

edited by

Shengying Qin

and

Cong Huai

submission deadline 30 Nov 2025 | Viewed by 93 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; precision medicine; individualized medicine

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Gut Microbiota and Cancers of the GI Tract: Role in Regulation, Prevention and Therapy

edited by Luka Bočkor and

Jurica Žučko

submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open

Keywords: gut microbiota; gastrointestinal cancers; gastrointestinal microbiota; anti-cancer therapies

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Activation and Regulation of NLRP3 Inflammasome

edited by

Wei Guo

submission deadline 30 Nov 2025 | Viewed by 88 | Submission Open

Keywords: NLRP3 inflammasome; innate immunity; inflammation; pyroptosis; caspase-1; IL-1β ; IL-18; DAMPs; PAMPs; inflammasome inhibitors; post-translational modifications; chronic inflammatory diseases; metabolic disorders; neurodegenerative diseases; therapeutic targeting

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Medically Assisted Reproduction

edited by

Theodoros Kalampokas

submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open

Keywords: infertility; medically assisted reproduction; reproductive endocrinology; clinical embryology; genetics; artificial intelligence; epigenetics; precision medicine; evidence-based medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Immunological Avalanches: Understanding Immune System Instability in Lupus, IgA Nephropathy, and Transplant Rejection

edited by

Davide Viggiano

, Giuseppe Gigliotti and Angelo Ferrantelli

submission deadline 30 Nov 2025 | Viewed by 85 | Submission Open

Keywords: immunological avalanche; lupus nephritis; IgA nephropathy; transplant rejection; complement dysregulation

(This special issue belongs to the Section Immunology and Immunotherapy)

Human Dental Stem Cells: The Last 25 Years

edited by

Christian Morsczeck

submission deadline 30 Nov 2025 | Viewed by 79 | Submission Open

Keywords: dental stem cells; regenerative dentistry; differentiation; periodontitis

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in the Molecular Biology of Transplantation

edited by Anil S. Paramesh

submission deadline 30 Nov 2025 | Viewed by 76 | Submission Open

Keywords: donor-derived cell-free DNA; Torque Teno Virus monitoring; gene expression profiling; kidney/pancreas transplants

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Human Immunodeficiency Virus (HIV): Past, Present and Future

edited by

Ana Borrajo

submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open

Keywords: HIV latency; ART; HIV reservoirs; NeuroHIV; immune activation; HIV cure strategies; virus– host interactions; HIV comorbidities; HIV and ageing; translational HIV research

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Fabry Disease: From Molecular Insights to Innovative Therapeutics

edited by

Yuri Battaglia

and Concetto Sessa

submission deadline 10 Dec 2025 | 6 articles | Viewed by 12628 | Submission Open

Keywords: fabry disease; lysosomal storage disorder; GLA gene mutations; enzyme replacement therapy; chaperone therapy; physical activity; imagining

(This special issue belongs to the Section Molecular and Translational Medicine)

Hepatotoxicity: From Pathology to Novel Therapeutic Approaches (2nd Edition)

edited by

Sanda Win

submission deadline 15 Dec 2025 | 2 articles | Viewed by 4262 | Submission Open

Keywords: cell death; reactive metabolites; oxidative stress; stress signaling; mitochondria; adaptive immunity; HLA associations; hepatotoxicity; drugs; liver injury; adverse drug reaction; drug-induced autoimmune hepatitis; idiosyncratic-drug-induced liver injury; bile acid; drug-induced cholestasis; hepatotoxins; steatosis; fibrosis

(This special issue belongs to the Section Molecular and Translational Medicine)

Extracellular Matrix in Health and Disorders (2nd Edition)

edited by

Caterina Licini

submission deadline 15 Dec 2025 | Viewed by 112 | Submission Open

Keywords: ECM; connective tissue; healthy tissues; pathological tissues; imaging; drug targets; markers; dermis; bone; tendon

(This special issue belongs to the Section Molecular and Translational Medicine)

Personalized Treatment in Cancer Research, Second Edition

edited by

Silvia De Francia

and

Sarah Allegra

submission deadline 30 Dec 2025 | Viewed by 78 | Submission Open

Keywords: cancer; personalized medicine; personalized treatment; pharmacogenetics; pharmacokinetics; chemotherapy; adjuvant treatment; therapeutic drug monitoring

(This special issue belongs to the Section Cancer Biology and Oncology)

SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of Vaccinations

edited by

Barbara Brogna

Marina Piscopo

and

Carlo Brogna

submission deadline 31 Dec 2025 | 7 articles | Viewed by 26677 | Submission Open

Keywords: SARS-CoV-2 complications; SARS-CoV2 prognostic and predictive biomarkers; long COVID-19 and autoimmune disease; COVID-19 and microbiome; artificial intelligence

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies

edited by

Foteini Christidi

and

Dimitrios Tsiptsios

submission deadline 31 Dec 2025 | 8 articles | Viewed by 15958 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; stroke; multiple sclerosis; epilepsy; neuromuscular disorders; demyelinating diseases; traumatic brain injury; clinical neurophysiology; neuroimaging; genetics; neuropsychological tests; molecular and cellular mechanisms; biomarkers; diagnosis and therapeutics; prognosis; neurorehabilitation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Serafino Fazio

and Valentina Mercurio

submission deadline 31 Dec 2025 | 9 articles | Viewed by 11668 | Submission Open

Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Heart Failure and Heart Transplantation

edited by

Nandan Kumar Mondal

submission deadline 31 Dec 2025 | 9 articles | Viewed by 11134 | Submission Open

Keywords: heart failure; heart transplantation; DBD (donation after brain death); DCD (donation after cardiac death); cardiac arrest; ischemic time and reperfusion injury; myocardial damage; preservation techniques; post-transplant outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Tumor Immune Microenvironment and Novel Strategies for Cancer Immunotherapy

edited by Sidra Islam

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10068 | Submission Open

Keywords: tumor microenvironment cancer immunotherapy; immune markers; tumor infilterating immune cells; tumors

(This special issue belongs to the Section Immunology and Immunotherapy)

Challenges in the Diagnosis and Treatment of Parkinson’s Disease

edited by Iro Boura and Cleanthe Spanaki

submission deadline 31 Dec 2025 | 5 articles | Viewed by 9982 | Submission Open

Keywords: Parkinson’ s disease; diagnosis; treatment; pathophysiology; biomarkers; prodromal; advanced therapies; subtypes; imaging; genetic

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advanced Research in Neuroprotection

edited by Evangelia Kesidou, Iliana Michailidou and

Christos Bakirtzis

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9791 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood– brain barrier

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Mechanisms, Implications, and Therapeutic Targets in Infectious Diseases

edited by Mihai Lazăr and Oana Săndulescu

submission deadline 31 Dec 2025 | 5 articles | Viewed by 9375 | Submission Open

Keywords: infectious diseases; virus; antibiotics; pathophysiology; molecular mechanism; therapeutic management

(This special issue belongs to the Section Immunology and Immunotherapy)

Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches

edited by

David J. Rademacher

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9150 | Submission Open

Keywords: cellular senescence; senescence-associated secretory phenotype; aging; senolytics; senomorphics; senoreverters; therapeutics

(This special issue belongs to the Section Cell Biology and Pathology)

Role of Factors in Embryo Implantation and Placental Development

edited by

Micol Massimiani

and Valentina Lacconi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8429 | Submission Open

Keywords: placental development; implantation; embryo development; pregnancy disorders; endometrium; implantation failure; recurrent pregnancy loss; decidualization

(This special issue belongs to the Section Molecular and Translational Medicine)

Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches

edited by

Lu Li

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7911 | Submission Open

Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions

(This special issue belongs to the Section Molecular and Translational Medicine)

Novel Biomarker and Treatments for Diabetic Neuropathy

edited by Arun V. Krishnan and Tushar Issar

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6301 | Submission Open

Keywords: diabetic peripheral neuropathy; type 1 diabetes; type 2 diabetes; glucagon-like peptide-1 receptor agonists; metabolic syndrome; in vivo corneal confocal microscopy; nerve ultrasonography; obesity; exercise

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Traumatic CNS Injury: From Bench to Bedside (2nd Edition)

edited by

Andres M. Rubiano

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5917 | Submission Open

Keywords: neurotrauma; traumatic brain injury; translational science; bench to bedside; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

The Promise and Challenge of Induced Pluripotent Stem Cells (iPSCs): 2nd Edition

edited by

Xiufang Guo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5360 | Submission Open

Keywords: iPSC; cell differentiation; disease model; disease-in-a-dish; body-on-a-chip; CRISPR/Cas9; gene edition; stem cell therapy; cell transplantation; translational

(This special issue belongs to the Section Molecular and Translational Medicine)

Biological Therapies for Asthma: Targeting Type 1 and Type 2 Inflammation

edited by Mohammad Irshad Reza and Nilesh Sudhakar Ambhore

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5072 | Submission Open

Keywords: asthma endotypes; type 1 inflammation; type 2 inflammation; biological therapies for asthma; non-type 2 asthma; cytokine pathways in asthma; precision medicine in asthma; inflammatory biomarkers in asthma; Th1/Th2 immune responses

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Hepatology

edited by Yuanwen Chen

submission deadline 31 Dec 2025 | 5 articles | Viewed by 4813 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); alcohol-associated liver disease (ALD); alcohol-associated hepatitis; viral hepatitis; liver cancer; autoimmune liver diseases; liver fibrosis; gut microbiota; neuroimmune; inflammatory mechanisms; oxidative stress; reversibly oxidized human non-mercaptalbumin-1; irreversibly oxidized human non-mercaptalbumin-2 (HNA2)

(This special issue belongs to the Section Molecular and Translational Medicine)

Epigenetic Regulation in Cancer Progression

edited by

Yonghwan Shin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4751 | Submission Open

Keywords: cancer progression; epigenetic regulation; gene expression; dysregulation; therapeutic targets

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Neurotransmitters in Health and Diseases

edited by

Zsolt Bagosi

and Krisztina Csabafi

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4341 | Submission Open

Keywords: neurotransmitters; GABA; dopamine; glutamate; acetylcholine; neurohormones; neuromodulators

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Molecular Research in Breast Cancer

edited by

Anna De Blasio

and

Daniela Carlisi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4325 | Submission Open

Keywords: breast cancer; apoptosis; signaling pathways; drug resistance; metastasis; cancer stem cells; microRNA; biomarkers; drug target; tumor metabolism; tumor immunity

(This special issue belongs to the Section Molecular and Translational Medicine)

Nano-Based Drug Delivery and Drug Discovery

edited by

Xiangli Shao

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4034 | Submission Open

Keywords: nanotechnology; drug discovery; drug delivery; nanocarriers; nanomaterials; drug targeting; drug release; drug therapeutic

(This special issue belongs to the Section Nanomedicine and Nanobiology)

New Insights in Hematologic Malignancies: From Pathophysiologic Mechanisms to Therapeutic Strategies

edited by

Yun Chen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3518 | Submission Open

Keywords: leukemia; hematological malignancies; tumor microenvironment; disease models; precision medicine; immunotherapy; targeted therapy; drug resistance; biomarkers; translational research

(This special issue belongs to the Section Cancer Biology and Oncology)

Antioxidant Materials with Additional Biological Properties

edited by

Nurettin Sahiner

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3266 | Submission Open

Keywords: natural antioxidants; flavonoids; and polyphenols; biocompatible and blood compatible; hydrogel; microgels; nanogel; and particles; polymeric particles; carbon quantum dots; and g-C3N4; stimuli-responsive materials; drug delivery systems; controlled release; and targeted delivery/therapies; antibacterial; antifungal; antiviral; anticancer; and biocidal; ROS-scavenging activity; proteins; enzyme; peptides; and amino acids; activate-able materials and photodynamic therapy

(This special issue belongs to the Section Biomedical Engineering and Materials)

New Insights in Respiratory Diseases

edited by

Diego Bagnasco

submission deadline 31 Dec 2025 | 5 articles | Viewed by 2996 | Submission Open

Keywords: asthma; COPD; bronchiectasis; genetic; therapeutics

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Psychiatric Disorders

edited by Wen Zhang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2719 | Submission Open

Keywords: psychiatric disorders; artificial intelligence; predictive modeling; personalized treatment strategies; animal experiments; risk factors; multimodal approaches

(This special issue belongs to the Section Molecular and Translational Medicine)

From Molecules to Minds: Translational Breakthroughs in Preclinical Psychiatry

edited by

Masaru Tanaka

Simone Battaglia

and

Sandra Barbalho

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2653 | Submission Open

Keywords: depression; anxiety; bipolar disorder; post-traumatic stress disorder; mental disorders; epigenomics; psychiatric disorders/genetics; circadian rhythm; sex characteristics; mitochondrial dysfunction; neurotoxins; intergenerational transmission; cannabinoid receptor modulators; adolescent neuroplasticity; synaptic pruning; psychoimmunology; preclinical studies; translational medical research; neuroplasticity; neuromodulation; phytochemicals; plant extracts; transcranial magnetic stimulation

(This special issue belongs to the Section Molecular and Translational Medicine)

Liver Disease: Etiology, Pathology, and Treatment

edited by Ivana Mikolašević

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1833 | Submission Open

Keywords: chronic liver disease; metabolic-associated fatty liver disease; liver fibrosis; liver injury; etiology; pathology; molecular and cellular mechanisms; biomarkers and therapeutic targets; immunotherapy; prevention and treatment

(This special issue belongs to the Section Cell Biology and Pathology)

Oxidative Stress in Health and Disease

edited by Federica Mannino

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1637 | Submission Open

Keywords: oxidative stress; inflammation; human diseases; apoptosis; peroxidation; DNA damage; mitochondria

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Reproductive Medicine and Health

edited by Athanasios Zikopoulos, Sofoklis Stavros and

Anastasios Potiris

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1607 | Submission Open

Keywords: reproductive medicine; assisted reproductive technology; fertility preservation; IVF; early pregnancy; miscarriages; proteomics; metabolomics; transcriptomics; infertility; bioethics; cryopreservation; personalized medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Recent Therapeutic Advances in Parkinson’s Disease

edited by

Chieh-Sen Chuang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1591 | Submission Open

Keywords: Parkinson's disease; disease-modifying therapy; continuous dopaminergic stimulation; non-dopaminergic drugs; deep brain stimulation; drug repurposing; immunotherapies; gene therapies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

State-of-the-Art Molecular and Translational Medicine in USA

edited by

Maaike van Gerwen

and

Stephanie J. Tuminello

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1564 | Submission Open

Keywords: diagnostics; therapeutics; prevention; cellular biology; disease mechanisms; precision medicine; biomarker discovery; immunotherapies; bioinformatics

(This special issue belongs to the Section Molecular and Translational Medicine)

Displaying special issue 251-300 on page 6 of 16.

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