Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Therapies for Neurodegenerative Diseases submission deadline 30 Nov 2025 | Viewed by 113 | Submission Open
Keywords: nanotechnology-based therapies; cellular and regenerative therapies; stem cell therapy; gene therapy and RNA interference; protein aggregation inhibitors; neuroinflammation modulators; mitochondrial dysfunction-targeted drugs; preclinical and clinical trials
(This special issue belongs to the Section Gene and Cell Therapy)
Nanoparticles and Biomaterials: Pioneering Innovations in Biomedical Device Engineering
edited by Eleni Papachristou
submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open
Keywords: nanoparticle NPs; biomaterials; drug delivery; mRNA delivery; antimicrobial activity; cancer; tissue regeneration; differentiation
(This special issue belongs to the Section Nanomedicine and Nanobiology)
From Cell Dysfunction to Prothrombotic Disorders: Molecular Pathways and Clinical Implications
edited by
submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open
Keywords: prothrombotic disorder; cellular dysfunction; hemostatic balance; thrombosis; novel biomarkers; antithrombotic therapies
(This special issue belongs to the Section Cell Biology and Pathology)
Advanced Research in Congenital Heart Disease (CHD)
edited by Paul Philipp Heinisch
submission deadline 30 Nov 2025 | Viewed by 109 | Submission Open
Keywords: congenital heart disease (CHD); biomaterials; imaging modalities
(This special issue belongs to the Section Molecular and Translational Medicine)
Basic and Clinical Research of Psychiatric Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 109 | Submission Open
Keywords: psychiatric diseases; anxiety disorder; PTSD; schizophrenia; Alzheimer’ s disease; autism spectrum disorder; depression
(This special issue belongs to the Section Molecular and Translational Medicine)
Structure-Based Drug Molecule Design and Organic Synthesis
edited by
submission deadline 30 Nov 2025 | Viewed by 105 | Submission Open
Keywords: molecular modeling; drug discovery; medicinal chemistry; structure-based (SB) drug design; artificial intelligence in drug design; software development for drug design; teaching methods in drug design
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Pharmacology of Pain and Inflammation
edited by Fernanda Regina de Castro Almeida and Francisco De Assis Oliveira
submission deadline 30 Nov 2025 | Viewed by 104 | Submission Open
Keywords: natural products; chronic pain; neuropathies; oncological pain; anti-inflammatory activity; pulmonary emphysema
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Mechanisms of Cellular Senescence and Inflammation in Cardiovascular Disease
edited by Sivareddy Kotla
submission deadline 30 Nov 2025 | Viewed by 100 | Submission Open
Keywords: cellular senescence; inflammation; cardiovascular disease
(This special issue belongs to the Section Cell Biology and Pathology)
Gut Microbiota and Cancers of the GI Tract: Role in Regulation, Prevention and Therapy
edited by Luka Bočkor and
submission deadline 30 Nov 2025 | Viewed by 93 | Submission Open
Keywords: gut microbiota; gastrointestinal cancers; gastrointestinal microbiota; anti-cancer therapies
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Advancing Pharmacogenetics and Pharmacogenomics in Pre-Clinical Research: Unveiling New Avenues for Precision Medicine
edited by and
submission deadline 30 Nov 2025 | Viewed by 93 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; precision medicine; individualized medicine
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Activation and Regulation of NLRP3 Inflammasome
edited by
submission deadline 30 Nov 2025 | Viewed by 88 | Submission Open
Keywords: NLRP3 inflammasome; innate immunity; inflammation; pyroptosis; caspase-1; IL-1β ; IL-18; DAMPs; PAMPs; inflammasome inhibitors; post-translational modifications; chronic inflammatory diseases; metabolic disorders; neurodegenerative diseases; therapeutic targeting
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Medically Assisted Reproduction submission deadline 30 Nov 2025 | Viewed by 88 | Submission Open
Keywords: infertility; medically assisted reproduction; reproductive endocrinology; clinical embryology; genetics; artificial intelligence; epigenetics; precision medicine; evidence-based medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Immunological Avalanches: Understanding Immune System Instability in Lupus, IgA Nephropathy, and Transplant Rejection
edited by , Giuseppe Gigliotti and Angelo Ferrantelli
submission deadline 30 Nov 2025 | Viewed by 85 | Submission Open
Keywords: immunological avalanche; lupus nephritis; IgA nephropathy; transplant rejection; complement dysregulation
(This special issue belongs to the Section Immunology and Immunotherapy)
Human Dental Stem Cells: The Last 25 Years submission deadline 30 Nov 2025 | Viewed by 80 | Submission Open
Keywords: dental stem cells; regenerative dentistry; differentiation; periodontitis
(This special issue belongs to the Section Cell Biology and Pathology)
Recent Advances in the Molecular Biology of Transplantation
edited by Anil S. Paramesh
submission deadline 30 Nov 2025 | Viewed by 76 | Submission Open
Keywords: donor-derived cell-free DNA; Torque Teno Virus monitoring; gene expression profiling; kidney/pancreas transplants
(This special issue belongs to the Section Immunology and Immunotherapy)
Advances in Human Immunodeficiency Virus (HIV): Past, Present and Future
edited by
submission deadline 30 Nov 2025 | Viewed by 64 | Submission Open
Keywords: HIV latency; ART; HIV reservoirs; NeuroHIV; immune activation; HIV cure strategies; virus– host interactions; HIV comorbidities; HIV and ageing; translational HIV research
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Fabry Disease: From Molecular Insights to Innovative Therapeutics
edited by and Concetto Sessa
submission deadline 10 Dec 2025 | 6 articles | Viewed by 12671 | Submission Open
Keywords: fabry disease; lysosomal storage disorder; GLA gene mutations; enzyme replacement therapy; chaperone therapy; physical activity; imagining
(This special issue belongs to the Section Molecular and Translational Medicine)
Hepatotoxicity: From Pathology to Novel Therapeutic Approaches (2nd Edition)
edited by
submission deadline 15 Dec 2025 | 2 articles | Viewed by 4287 | Submission Open
Keywords: cell death; reactive metabolites; oxidative stress; stress signaling; mitochondria; adaptive immunity; HLA associations; hepatotoxicity; drugs; liver injury; adverse drug reaction; drug-induced autoimmune hepatitis; idiosyncratic-drug-induced liver injury; bile acid; drug-induced cholestasis; hepatotoxins; steatosis; fibrosis
(This special issue belongs to the Section Molecular and Translational Medicine)
Extracellular Matrix in Health and Disorders (2nd Edition)
edited by
submission deadline 15 Dec 2025 | Viewed by 113 | Submission Open
Keywords: ECM; connective tissue; healthy tissues; pathological tissues; imaging; drug targets; markers; dermis; bone; tendon
(This special issue belongs to the Section Molecular and Translational Medicine)
Personalized Treatment in Cancer Research, Second Edition submission deadline 30 Dec 2025 | Viewed by 78 | Submission Open
Keywords: cancer; personalized medicine; personalized treatment; pharmacogenetics; pharmacokinetics; chemotherapy; adjuvant treatment; therapeutic drug monitoring
(This special issue belongs to the Section Cancer Biology and Oncology)
SARS-CoV-2 Infection: Focus on Pathophysiological Characteristics, Complications and Effects of Vaccinations submission deadline 31 Dec 2025 | 7 articles | Viewed by 26746 | Submission Open
Keywords: SARS-CoV-2 complications; SARS-CoV2 prognostic and predictive biomarkers; long COVID-19 and autoimmune disease; COVID-19 and microbiome; artificial intelligence
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies submission deadline 31 Dec 2025 | 8 articles | Viewed by 16322 | Submission Open
Keywords: neurological diseases; neurodegenerative diseases; stroke; multiple sclerosis; epilepsy; neuromuscular disorders; demyelinating diseases; traumatic brain injury; clinical neurophysiology; neuroimaging; genetics; neuropsychological tests; molecular and cellular mechanisms; biomarkers; diagnosis and therapeutics; prognosis; neurorehabilitation
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches
edited by and Valentina Mercurio
submission deadline 31 Dec 2025 | 9 articles | Viewed by 11766 | Submission Open
Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research on Heart Failure and Heart Transplantation submission deadline 31 Dec 2025 | 9 articles | Viewed by 11208 | Submission Open
Keywords: heart failure; heart transplantation; DBD (donation after brain death); DCD (donation after cardiac death); cardiac arrest; ischemic time and reperfusion injury; myocardial damage; preservation techniques; post-transplant outcomes
(This special issue belongs to the Section Molecular and Translational Medicine)
Tumor Immune Microenvironment and Novel Strategies for Cancer Immunotherapy
edited by Sidra Islam
submission deadline 31 Dec 2025 | 6 articles | Viewed by 10131 | Submission Open
Keywords: tumor microenvironment cancer immunotherapy; immune markers; tumor infilterating immune cells; tumors
(This special issue belongs to the Section Immunology and Immunotherapy)
Challenges in the Diagnosis and Treatment of Parkinson’s Disease
edited by Iro Boura and Cleanthe Spanaki
submission deadline 31 Dec 2025 | 5 articles | Viewed by 10033 | Submission Open
Keywords: Parkinson’ s disease; diagnosis; treatment; pathophysiology; biomarkers; prodromal; advanced therapies; subtypes; imaging; genetic
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advanced Research in Neuroprotection
edited by Evangelia Kesidou, Iliana Michailidou and
submission deadline 31 Dec 2025 | 4 articles | Viewed by 9840 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood– brain barrier
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Mechanisms, Implications, and Therapeutic Targets in Infectious Diseases
edited by Mihai Lazăr and Oana Săndulescu
submission deadline 31 Dec 2025 | 5 articles | Viewed by 9420 | Submission Open
Keywords: infectious diseases; virus; antibiotics; pathophysiology; molecular mechanism; therapeutic management
(This special issue belongs to the Section Immunology and Immunotherapy)
Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches submission deadline 31 Dec 2025 | 3 articles | Viewed by 9171 | Submission Open
Keywords: cellular senescence; senescence-associated secretory phenotype; aging; senolytics; senomorphics; senoreverters; therapeutics
(This special issue belongs to the Section Cell Biology and Pathology)
Role of Factors in Embryo Implantation and Placental Development
edited by and Valentina Lacconi
submission deadline 31 Dec 2025 | 4 articles | Viewed by 8460 | Submission Open
Keywords: placental development; implantation; embryo development; pregnancy disorders; endometrium; implantation failure; recurrent pregnancy loss; decidualization
(This special issue belongs to the Section Molecular and Translational Medicine)
Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7939 | Submission Open
Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Biomarker and Treatments for Diabetic Neuropathy
edited by Arun V. Krishnan and Tushar Issar
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6376 | Submission Open
Keywords: diabetic peripheral neuropathy; type 1 diabetes; type 2 diabetes; glucagon-like peptide-1 receptor agonists; metabolic syndrome; in vivo corneal confocal microscopy; nerve ultrasonography; obesity; exercise
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Traumatic CNS Injury: From Bench to Bedside (2nd Edition)
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5981 | Submission Open
Keywords: neurotrauma; traumatic brain injury; translational science; bench to bedside; neuroprotection
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
The Promise and Challenge of Induced Pluripotent Stem Cells (iPSCs): 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5370 | Submission Open
Keywords: iPSC; cell differentiation; disease model; disease-in-a-dish; body-on-a-chip; CRISPR/Cas9; gene edition; stem cell therapy; cell transplantation; translational
(This special issue belongs to the Section Molecular and Translational Medicine)
Biological Therapies for Asthma: Targeting Type 1 and Type 2 Inflammation
edited by Mohammad Irshad Reza and Nilesh Sudhakar Ambhore
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5120 | Submission Open
Keywords: asthma endotypes; type 1 inflammation; type 2 inflammation; biological therapies for asthma; non-type 2 asthma; cytokine pathways in asthma; precision medicine in asthma; inflammatory biomarkers in asthma; Th1/Th2 immune responses
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Hepatology
edited by Yuanwen Chen
submission deadline 31 Dec 2025 | 5 articles | Viewed by 4866 | Submission Open
Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); alcohol-associated liver disease (ALD); alcohol-associated hepatitis; viral hepatitis; liver cancer; autoimmune liver diseases; liver fibrosis; gut microbiota; neuroimmune; inflammatory mechanisms; oxidative stress; reversibly oxidized human non-mercaptalbumin-1; irreversibly oxidized human non-mercaptalbumin-2 (HNA2)
(This special issue belongs to the Section Molecular and Translational Medicine)
Epigenetic Regulation in Cancer Progression
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4761 | Submission Open
Keywords: cancer progression; epigenetic regulation; gene expression; dysregulation; therapeutic targets
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Molecular Research in Breast Cancer submission deadline 31 Dec 2025 | 2 articles | Viewed by 4363 | Submission Open
Keywords: breast cancer; apoptosis; signaling pathways; drug resistance; metastasis; cancer stem cells; microRNA; biomarkers; drug target; tumor metabolism; tumor immunity
(This special issue belongs to the Section Molecular and Translational Medicine)
Neurotransmitters in Health and Diseases
edited by and Krisztina Csabafi
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4351 | Submission Open
Keywords: neurotransmitters; GABA; dopamine; glutamate; acetylcholine; neurohormones; neuromodulators
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Nano-Based Drug Delivery and Drug Discovery
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4039 | Submission Open
Keywords: nanotechnology; drug discovery; drug delivery; nanocarriers; nanomaterials; drug targeting; drug release; drug therapeutic
(This special issue belongs to the Section Nanomedicine and Nanobiology)
New Insights in Hematologic Malignancies: From Pathophysiologic Mechanisms to Therapeutic Strategies
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3572 | Submission Open
Keywords: leukemia; hematological malignancies; tumor microenvironment; disease models; precision medicine; immunotherapy; targeted therapy; drug resistance; biomarkers; translational research
(This special issue belongs to the Section Cancer Biology and Oncology)
Antioxidant Materials with Additional Biological Properties
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3276 | Submission Open
Keywords: natural antioxidants; flavonoids; and polyphenols; biocompatible and blood compatible; hydrogel; microgels; nanogel; and particles; polymeric particles; carbon quantum dots; and g-C3N4; stimuli-responsive materials; drug delivery systems; controlled release; and targeted delivery/therapies; antibacterial; antifungal; antiviral; anticancer; and biocidal; ROS-scavenging activity; proteins; enzyme; peptides; and amino acids; activate-able materials and photodynamic therapy
(This special issue belongs to the Section Biomedical Engineering and Materials)
New Insights in Respiratory Diseases
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 3044 | Submission Open
Keywords: asthma; COPD; bronchiectasis; genetic; therapeutics
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research on Psychiatric Disorders
edited by Wen Zhang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2739 | Submission Open
Keywords: psychiatric disorders; artificial intelligence; predictive modeling; personalized treatment strategies; animal experiments; risk factors; multimodal approaches
(This special issue belongs to the Section Molecular and Translational Medicine)
From Molecules to Minds: Translational Breakthroughs in Preclinical Psychiatry submission deadline 31 Dec 2025 | 1 articles | Viewed by 2668 | Submission Open
Keywords: depression; anxiety; bipolar disorder; post-traumatic stress disorder; mental disorders; epigenomics; psychiatric disorders/genetics; circadian rhythm; sex characteristics; mitochondrial dysfunction; neurotoxins; intergenerational transmission; cannabinoid receptor modulators; adolescent neuroplasticity; synaptic pruning; psychoimmunology; preclinical studies; translational medical research; neuroplasticity; neuromodulation; phytochemicals; plant extracts; transcranial magnetic stimulation
(This special issue belongs to the Section Molecular and Translational Medicine)
Liver Disease: Etiology, Pathology, and Treatment
edited by Ivana Mikolašević
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1838 | Submission Open
Keywords: chronic liver disease; metabolic-associated fatty liver disease; liver fibrosis; liver injury; etiology; pathology; molecular and cellular mechanisms; biomarkers and therapeutic targets; immunotherapy; prevention and treatment
(This special issue belongs to the Section Cell Biology and Pathology)
Oxidative Stress in Health and Disease
edited by Federica Mannino
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1649 | Submission Open
Keywords: oxidative stress; inflammation; human diseases; apoptosis; peroxidation; DNA damage; mitochondria
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Reproductive Medicine and Health
edited by Athanasios Zikopoulos, Sofoklis Stavros and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1615 | Submission Open
Keywords: reproductive medicine; assisted reproductive technology; fertility preservation; IVF; early pregnancy; miscarriages; proteomics; metabolomics; transcriptomics; infertility; bioethics; cryopreservation; personalized medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Recent Therapeutic Advances in Parkinson’s Disease
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1600 | Submission Open
Keywords: Parkinson's disease; disease-modifying therapy; continuous dopaminergic stimulation; non-dopaminergic drugs; deep brain stimulation; drug repurposing; immunotherapies; gene therapies
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
State-of-the-Art Molecular and Translational Medicine in USA submission deadline 31 Dec 2025 | 2 articles | Viewed by 1578 | Submission Open
Keywords: diagnostics; therapeutics; prevention; cellular biology; disease mechanisms; precision medicine; biomarker discovery; immunotherapies; bioinformatics
(This special issue belongs to the Section Molecular and Translational Medicine)
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