Molecular Researches in Pro-thrombotic Disorders

Dear Colleagues,

Cardiovascular and cerebrovascular diseases, chronic obstructive pulmonary disease, diabetes, and cancer are the leading causes of death worldwide. They share common ground in the form of inflammation that contributes to the onset of a systemic hypercoagulable state, initiating continuous crosstalk between phlogistic and thrombotic processes. In this context, vascular cells such as platelets, endothelial cells, pericytes, and inflammatory cells (i.e., neutrophils, macrophages), interact through a plethora of substances, including cytokines and chemokines that promote a prothrombotic state. The heterogeneous clinical sequelae include myocardial infarction, stroke, venous deep thrombosis and pulmonary embolisms, splanchnic thrombosis, and peripheral arterial disease. These complications worsen the prognosis and increase the mortality of any chronic disease. 

This Special Issue welcomes original articles and reviews that contribute to understanding the molecular pathways involved in prothrombotic states; better comprehension of the molecular signaling that underlies such conditions could lead to the identification of new therapeutic mechanisms targets.

Dr. Cristina Barale
Guest Editor

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