Novel Strategy for Treating Castration-Resistant Prostate Cancer

Dear Colleagues,

Prostate cancer is the most frequently diagnosed cancer among men. Androgen deprivation therapy (ADT) has emerged as a first-line therapy for initial management of advanced or metastatic prostate cancer; however, many patients eventually develop castration-resistant prostate cancer (CRPC) and distant metastasis, accounting for the majority of the mortality from the prostate cancer. Although several new options for the treatment of metastatic CRPC (mCRPC) have been approved in the last few years: the CYP17 inhibitor abiraterone, the androgen receptor (AR) antagonist enzalutamide, the taxane cabazitaxel, the immunotherapy sipuleucel-T and the alpha-emmitter radium-223 for men with bone metastases, CRPC remains incurable. To improve the therapeutic efficacy of CRPC or develop a novel therapeutic agent is urgently needed. This Special Issue of Biomedicines, entitled “Novel strategy for treating castration-resistant prostate cancer,” will include reviews that describe novel strategies for treating CRPC developed over the past few years as well as original research articles that describe novel strategies for treating CRPC using preclinical and/or translational studies. In addition, studies in combination therapy, drug response, tumor microenvironment, and mechanistic approaches will be accepted.

Prof. Dr. Shu-Pin Huang
Dr. Chia-Yang Li
Guest Editors

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