Molecular Research of Brain Tumors

Dear Colleagues,

Brain tumours are biologically heterogeneous diseases characterised by complex molecular alterations, cellular plasticity, and dynamic interactions with the surrounding brain microenvironment. Despite advances in molecular classification, diagnostics, precision oncology, and therapeutic approaches, major gaps remain in understanding the mechanisms that drive tumour initiation, progression, treatment resistance, recurrence, and variable treatment responses.

This Special Issue aims to bring together basic, translational, and clinical research that advances our understanding of the molecular biology of primary and secondary brain tumours and supports the development of precision oncology approaches. Areas of interest include tumour plasticity and heterogeneity, the tumour microenvironment, neuro–brain tumour interactions, molecular mechanisms of tumour progression and therapeutic response, and the identification and validation of diagnostic, prognostic, predictive, and therapeutic biomarkers. Studies employing genomics, transcriptomics, proteomics, multi-omics, molecular and advanced imaging, and integrative computational approaches are particularly encouraged.

We welcome studies ranging from in vitro and ex vivo models to animal studies, patient-derived models, and clinical investigations. This includes research identifying novel mechanisms, pathways, molecular targets, biomarkers, or therapeutic strategies; studies advancing patient stratification, treatment selection, treatment-response prediction, and other precision oncology applications; and work that strengthens current biological knowledge, addresses empirical or translational gaps, or provides new insights into established mechanisms.

Original research, translational and clinical studies, methodological advances, and comprehensive reviews contributing to improved understanding, diagnosis, prognosis, therapeutic development, and precision management of brain tumours are encouraged.

Dr. Muhamad Noor Alfarizal Kamarudin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.