New Insights into Motor Neuron Diseases

Dear Colleagues,

Motor neuron diseases include a variety of rare diseases characterized by progressive disability and a significant psychological, social, and economic burden. Their extreme genetic, pathology, and phenotype heterogeneity make them major causes of clinical trial failure and the substantial absence of effective treatments. Furthermore, the still incomplete knowledge of their pathogenic mechanisms and risk factors, especially environmental ones, complicates the search for a personalized therapeutic approach.

Nonetheless, in the last few years, considerable progress has been made in the study of motor neuron diseases, especially in the genetic field, with consequent and important therapeutic implications.

This Special Issue aims to collect high-quality papers on the emerging research on motor neuron diseases, with special consideration of new insights into disease pathomechanisms and possible genetic and/or environmental risk factors, biological and clinical heterogeneity, biomarkers, and studies aimed at identifying potential treatment targets. As we believe this field could benefit from multidisciplinary approaches, contributions including basic, translational, and clinical studies are strongly encouraged.

Dr. Jessica Mandrioli
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.