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Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Reprogramming Life: Synthetic Biology Approaches for Next-Gen Strain Engineering

edited by Thanaporn Laothanachareon,

Chitwadee Phithakrotchanakoon

and

Nunthaphan Vikromvarasiri

submission deadline 31 Jul 2026 | Viewed by 384 | Submission Open

Keywords: synthetic biology; strain engineering; metabolic pathway redesign; CRISPR/Cas genome editing; microbial cell factories; multi-omics integration; AI-driven metabolic design; sustainable bioproduction

(This special issue belongs to the Section Biotechnology)

Advances in Plant Genomics and Genome Editing

edited by Xuean Cui

submission deadline 31 Jul 2026 | Viewed by 356 | Submission Open

Keywords: plant genomes; plant genomics; genome sequencing; plant genome engineering; CRISPR/Cas; gene knock-out; gene knock-in; base editor; prime editor; genome editing tools; multiplex genome editing; gene expression regulation; plant trait improvement

(This special issue belongs to the Section Genetics and Genomics)

Exploring the Role of Serotonin in Psychiatric Disorders

edited by

Georgianna Gould

submission deadline 31 Jul 2026 | Viewed by 226 | Submission Open

Keywords: diet; drug treatments; enzymes; epigenetic; post translational modification; serotonin metabolism; serotonin receptors; serotonin transporters

(This special issue belongs to the Section Neuroscience)

Environmental and Nutritional Stress: Metabolic Consequences and Regulatory Strategies in Animals

edited by

Wenqiang Ma

submission deadline 31 Jul 2026 | Viewed by 135 | Submission Open

Keywords: stress physiology; metabolic dysfunction; environmental stress; nutritional stress; gut microbiota; bioactive compounds

(This special issue belongs to the Section Physiology)

Epilepsy: The Mechanisms of Seizure, Termination, and Biomarker Development

edited by

Keisuke Maeda

submission deadline 31 Jul 2026 | Viewed by 122 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; seizure dynamics; termination; biomarkers; neural excitability; neuroscience

(This special issue belongs to the Section Neuroscience)

Animal Cognition and Decision Strategies: From Behaviour to Computation

edited by

HaDi MaBouDi

and

Alice Bridges

submission deadline 31 Jul 2026 | Viewed by 78 | Submission Open

Keywords: animal models; bio-inspired computation; brain– behaviour mapping; cognitive mechanisms; cognitive neuroscience; cognitive strategies; comparative cognition; computational modelling; decision-making; learning and adaptation; naturalistic behaviour; neural computation; neuroethology

(This special issue belongs to the Section Neuroscience)

Regulation of Gene Expression in Immune Cell Development and Function

edited by Bon Quy Trinh

submission deadline 31 Jul 2026 | Viewed by 51 | Submission Open

Keywords: noncoding RNA; enhancer; silencer; transposable element; epigenetics; chromatin structure and architecture; innate immunology; adaptive immunology; development; functions

(This special issue belongs to the Section Immunology)

Applications of Gene Expression Profiling in Human Disease

edited by

Lipei Shao

submission deadline 31 Jul 2026 | Viewed by 20 | Submission Open

Keywords: gene expression profile; biomarkers; cancer; complex disease

(This special issue belongs to the Section Genetics and Genomics)

Aquatic Alien Invasions and Their Impact on Biodiversity and Ecosystem Services—3rd Edition

edited by

Giorgio Mancinelli

Paraskevi K. Karachle

Elena Tricarico

and

Baran Yoğurtçuoğlu

submission deadline 31 Jul 2026 | Viewed by 1 | Submission Open

Keywords: species; aquatic invasions; biodiversity; ecosystem services; conservation

(This special issue belongs to the Section Marine Biology)

Ferroptosis: Mechanisms and Human Disease

edited by Chan-Yen Kuo

submission deadline 15 Aug 2026 | 3 articles | Viewed by 7990 | Submission Open

Keywords: ferroptosis; systemic diseases; inflammatory response; mitochondrial-dependent redox homeostasis; microenvironment

(This special issue belongs to the Section Cell Biology)

Changing Coral Reef Biodiversity and Function in the Anthropocene

edited by

Morgan Pratchett

submission deadline 15 Aug 2026 | Viewed by 365 | Submission Open

Keywords: anthropogenic stressors; coral reefs; climate change; biodiversity loss; marine conservation; ecological adaptation; ecosystem function; resilience

(This special issue belongs to the Section Marine Biology)

Role of CARD9 in Health and Diseases

edited by Zuberwasim Sayyad and Nikhil Sharma

submission deadline 15 Aug 2026 | Viewed by 129 | Submission Open

Keywords: CARD9; innate immunity; pattern recognition receptors; autophagy; apoptosis; inflammasome; reactive oxygen species; post-translational modifications; gut microbiota; inflammation and cancer

Recent Advances in Angiogenesis and Vascular Development

edited by

Concetta Scimone

and

Rosalia D’Angelo

submission deadline 15 Aug 2026 | Viewed by 25 | Submission Open

Keywords: vasculogenesis; angiogenesis; vascular differentiation markers; endothelial-to-mesenchymal transition (EndMT); mechanotransduction; endothelial function; endothelial damage

(This special issue belongs to the Section Cell Biology)

The Role of Autophagy and Macrophages in Modulating Immune Responses in Atherosclerosis

edited by

Kumar Prabhash Jha

and Aatira Vijay

submission deadline 25 Aug 2026 | Viewed by 131 | Submission Open

Keywords: atherosclerosis; macrophages; autophagy; immune regulation; chronic inflammation; plaque stability; lipid metabolism; efferocytosis; immunometabolism

Population Genetics and Conservation of Amphibians and Reptiles

edited by

Fang Yan

submission deadline 25 Aug 2026 | Viewed by 76 | Submission Open

Keywords: conservation genetics; local adaptation; genetic diversity; amphibian; reptile; environmental change

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Animal Models of Arthritis

edited by Nevena Arsenović-Ranin and Biljana Bufan

submission deadline 30 Aug 2026 | 4 articles | Viewed by 10377 | Submission Open

Keywords: animal models; rheumatoid arthritis; osteoarthritis; inflammation; immunopathology; pathological features; joints; treatment; drug screening; traditional medicine

(This special issue belongs to the Section Medical Biology)

Young Researchers in Neuroscience

edited by Yansheng Du

submission deadline 31 Aug 2026 | 4 articles | Viewed by 31092 | Submission Open

Keywords: neurobiology; cell biology; molecular mechanisms; neural development; synaptic function; ion channels; neurotransmitter systems; gene expression; neuronal signaling; cellular physiology

(This special issue belongs to the Section Neuroscience)

Bone Cell Biology

edited by Yohei Abe and

Giulia Lanzolla

submission deadline 31 Aug 2026 | 7 articles | Viewed by 16713 | Submission Open

Keywords: osteoclast; osteoblast; osteocyte; bone density; macrophage; RANK; transcription factor; cell signaling

(This special issue belongs to the Section Cell Biology)

Biology, Ecology and Management of Harmful Algae

edited by Paul V. Zimba and

Jabulani R. Gumbo

submission deadline 31 Aug 2026 | 6 articles | Viewed by 8714 | Submission Open

Keywords: harmful algae; toxic algae; harmful algal bloom (HAB); excessive algae growth; microalgae and macroalgae; cyanobacteria; dinoflagellates; toxins; water quality; phytoplankton; water resources

Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular Disease

edited by

Mridula Chopra

Helen L. Fillmore

and

Maurizio Forte

submission deadline 31 Aug 2026 | 2 articles | Viewed by 8370 | Submission Open

Keywords: cancer; cardiovascular disease; biomarkers; gut microbiome; inflammation; health policy; diet and lifestyle

Lipid Metabolism in Plant Growth and Development

edited by Xiaohong Yu and Yingqi Cai

submission deadline 31 Aug 2026 | 2 articles | Viewed by 4149 | Submission Open

Keywords: lipid metabolism; lipid engineering; plant growth; plant development; lipid biosynthesis; lipid signaling; lipid transport; membrane structure; energy storage; plant– microbe interactions; stress response; nutrition value; cellular process

(This special issue belongs to the Section Plant Science)

Cellular and Molecular Biology of Liver Diseases

edited by Matthew McMillin

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1475 | Submission Open

Keywords: drug-induced liver injury; cholestasis; hepatitis; metabolic dysfunction-associated steatotic liver disease; alcohol-associated liver disease

(This special issue belongs to the Section Cell Biology)

Regenerative Biology: Regeneration After Spinal Cord and Peripheral Nerve Injury

edited by

Alexandre Leite Rodrigues de Oliveira

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1225 | Submission Open

Keywords: neuronal regeneration; peripheral nerve repair; spinal cord injury; axonal growth; neuroplasticity; glial cells; molecular signaling pathways; stem cells in nerve regeneration; neuroinflammation; animal models of nerve injury

(This special issue belongs to the Section Neuroscience)

Host–Microbiome–Environment Interactions in Domestic and Wild Animals

edited by

Cesar A. Rosales-Nieto

and Cesar A. Meza-Herrera

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1225 | Submission Open

Keywords: animal microbiome; environmental microbiota; host– microbiota interactions; wildlife microbiology; livestock health and productivity; microbiome and conservation; One Health approach; gut microbiota dynamics; microbial ecology; microbiome and reproduction; habitat– host microbiome linkages; multi-omics integration

(This special issue belongs to the Section Microbiology)

Microbiology and Metabolomics in Reproductive Biology

edited by

Giuseppina Campisciano

submission deadline 31 Aug 2026 | Viewed by 352 | Submission Open

Keywords: maternal microbiome; metabolome; pregnancy outcomes; fetal development; biomarkers; immune function; metabolic health; disease prediction; therapeutic interventions; maternal and child health

(This special issue belongs to the Section Developmental and Reproductive Biology)

Advances in Cardiac and Vascular Biology: From Mechanisms to Pathophysiology

edited by

Hanqiang Deng

and

Haodi Wu

submission deadline 31 Aug 2026 | Viewed by 221 | Submission Open

Keywords: cardiovascular biology; molecular mechanisms; cellular signaling; epigenomic regulation; vascular remodeling; metabolic reprogramming; cardiac pathophysiology

(This special issue belongs to the Section Physiology)

Advances in Leishmaniasis and Chagas Disease: Biology, Epidemiology, Treatment and Control (2nd Edition)

edited by

Fernando Almeida-Souza

Flávia de Oliveira Cardoso

and

Kátia Da Silva Calabrese

submission deadline 31 Aug 2026 | Viewed by 194 | Submission Open

Keywords: leishmaniasis; Chagas disease; immunopathogeny; diagnosis; epidemiology; control; vaccine

Bone Mechanics: From Cells to Organs, to Function

edited by

Viviana Toro-Ibacache

submission deadline 31 Aug 2026 | Viewed by 190 | Submission Open

Keywords: bone mechanics; bone remodeling; mechanotransduction; structural analysis; functional morphology; bioengineering

(This special issue belongs to the Section Physiology)

Biophysics of Exposome: Molecular Mechanisms of Action

edited by

Judith Klein-Seetharaman

and Madhavi K. Ganapathiraju

submission deadline 31 Aug 2026 | Viewed by 157 | Submission Open

Keywords: computational biology; systems biology; mass spectrometry; protein– ligand networks; protein– protein interaction networks; metabolomics; proteomics; surface plasmon resonance; protein structure prediction; molecular docking; target fishing; machine learning; artificial intelligence

Current Status and Future Perspectives on Lipid Biology and Beyond

edited by

Jasmina Debeljak Martacic

and

Slavica Ranković

submission deadline 31 Aug 2026 | Viewed by 129 | Submission Open

Keywords: lipids; fatty acids (FAs); omega-3 (FA); omega-6 (FA); cancer; cell biology; oxylipins; oxidative stress; lipidomics; lipid nanoparticles; personalized lipid-based therapies

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Fruits and Seeds of Tropical Plants: Conservation of Species, Ecological Importance and Quality Valorization

edited by Edna Ursulino Alves and Silvanda De Melo Silva

submission deadline 31 Aug 2026 | Viewed by 118 | Submission Open

Keywords: climate change; nature conservation; biodiversity; plant propagation; postharvest quality; metabolic profile; orchard management and quality

(This special issue belongs to the Section Conservation Biology and Biodiversity)

Energy Metabolism, Genetics and Development in Drosophila

edited by

Do-Hwan Lim

submission deadline 31 Aug 2026 | Viewed by 88 | Submission Open

Keywords: Drosophila; energy metabolism; development; epigenetics; non-coding RNAs; metabolic disease; growth; signaling pathway

(This special issue belongs to the Section Bioinformatics)

Research Progress on Metabolic Pathways in Neurodegenerative Diseases

edited by Ali H. Rafati

submission deadline 31 Aug 2026 | Viewed by 71 | Submission Open

Keywords: neurodegeneration; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; autophagy; neuroinflammation; biomarkers; therapeutic targets

(This special issue belongs to the Section Neuroscience)

Mitochondrial Genomics of Arthropods

edited by Renfu Shao

submission deadline 31 Aug 2026 | Viewed by 41 | Submission Open

Keywords: mitochondrial genome architecture; transcriptional dynamics; translational mechanisms; comparative genomics; molecular evolution; arthropod phylogenetics; systematics; evolutionary biology

(This special issue belongs to the Section Genetics and Genomics)

Novel Mechanisms and Biological Processes in Redox and Inflammatory Signaling

edited by Shengchen Wang and

Demin Cai

submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open

Keywords: redox; inflammatory; oxidative stress; antioxidant; anti-inflammatory; signaling pathways

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Biogenesis and Function of Centrioles, Centrosomes, and Primary Cilia in Health and Disease

edited by

Ramona Lattao

and

Hélène Rangone

submission deadline 31 Aug 2026 | Viewed by 31 | Submission Open

Keywords: centriole; centrosome; cilia

(This special issue belongs to the Section Cell Biology)

Uncovering the Role of T Cells in Immune Homeostasis and Immune Tolerance

edited by

Yohei Sato

submission deadline 31 Aug 2026 | Viewed by 17 | Submission Open

Keywords: regulatory T cells; immune tolerance; FOXP3; cytokine; suppression

(This special issue belongs to the Section Cell Biology)

Biosynthesis of Metabolites from Microorganisms, or Microorganism-Host Interaction? (Volume II)

edited by

Fengli Zhang

Zhiqiang Liu

and

Michel Denis

submission deadline 1 Sep 2026 | 6 articles | Viewed by 16806 | Submission Open

Keywords: biosynthesis; biological activity; biosynthesis regulation; microbial metabolites; microbe– host reaction

(This special issue belongs to the Section Microbiology)

Viral Infections in Animals: Pathogenesis and Immunity

edited by

Yang Li

submission deadline 1 Sep 2026 | 1 articles | Viewed by 1496 | Submission Open

Keywords: virus– host interactions; antiviral immunity; mechanisms of viral pathogenesis

(This special issue belongs to the Section Immunology)

Latest Discoveries in Non-Model Organisms and Non-Translational Biology

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 8 Sep 2026 | Viewed by 137 | Submission Open

Keywords: basic biological research; non-translational biology; non-clinical biology; fundamental science; non-model organisms; model organisms; scientific curiosity– driven research; biological diversity; experimental biology; theoretical biology

Feature Papers on Developmental and Reproductive Biology

edited by

Jacek Z. Kubiak

submission deadline 15 Sep 2026 | 10 articles | Viewed by 23923 | Submission Open

Keywords: embryo/fetus development; reproductive biology; gametogenesis; differentiation; growth; homeostasis; regeneration; aging; cell cycle regulation; stem cells; organoids

(This special issue belongs to the Section Developmental and Reproductive Biology)

Molecular and Cellular Mechanisms of Neuroinflammation and Chronic Pain

edited by Mario Garcia-Dominguez

submission deadline 15 Sep 2026 | Viewed by 26 | Submission Open

Keywords: neuroinflammation; chronic pain; neuroimmune interactions; glial activation; cytokine signaling; synaptic plasticity; oxidative stress; epigenetic regulation; microglia and astrocytes; therapeutic targets

(This special issue belongs to the Section Neuroscience)

Plant Breeding: From Biology to Biotechnology

edited by Juwu Gong

submission deadline 30 Sep 2026 | 5 articles | Viewed by 7633 | Submission Open

Keywords: plant breeding; biotechnology; molecular marker-assisted selection; genetic engineering; genome editing; tissue culture; phenotype; genetics; omics

(This special issue belongs to the Section Biotechnology)

Molecular Basis of Bone Homeostasis and Skeletal Diseases

edited by

Weirong Xing

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5267 | Submission Open

Keywords: osteoclast; osteoblast; bone; skeletal disease; bone formation; bone resorption; osteoporosis; osteopetrosis; human genetics; mouse genetics

(This special issue belongs to the Section Biochemistry and Molecular Biology)

Signalling Pathways in Cancer and Disease

edited by

Ahmed Elbediwy

and

Nadine Wehida

submission deadline 30 Sep 2026 | 5 articles | Viewed by 4650 | Submission Open

Keywords: cancer; signalling; metastasis; tumorigenesis; cancer targeting

(This special issue belongs to the Section Cancer Biology)

Research Advancements in Oral Biology

edited by

Jelena R. Roganović

and Nina Petrović

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2768 | Submission Open

Keywords: oral biology; oral tissue regeneration; artificial intelligence (AI) in dentistry; genomics and proteomics in dentistry; dental research; salivary diagnostics

(This special issue belongs to the Section Medical Biology)

The Role of Innate Immunity in Organ Transplantation

edited by Todd V. Brennan

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1176 | Submission Open

Keywords: innate immunity; allograft rejection; transplantation; immune tolerance

(This special issue belongs to the Section Medical Biology)

Molecular Mechanisms of Cell Signal Transduction

edited by

Wenjing Zhang

submission deadline 30 Sep 2026 | Viewed by 451 | Submission Open

Keywords: molecular interactions in signaling; phosphorylation and signal propagation; post-translational modifications; cross-talk between signaling pathways; cellular response to extracellular stimuli; metabolic regulation and signaling; signaling in cancer progression; inflammatory signaling pathways; role of signaling in stem cell differentiation; innovative imaging techniques for signaling

(This special issue belongs to the Section Cell Biology)

Physiology and Ecology of Animal Parasites and Related Diseases

edited by Marcela K. Castelo

submission deadline 30 Sep 2026 | Viewed by 398 | Submission Open

Keywords: parasites; parasitoids; physiology; ecology; ecophysiology; diseases; global change

(This special issue belongs to the Section Zoology)

More than a Shield: The Secret Functions of Epithelial Cells in Homeostasis and Infections

edited by