Exploring the Role of Serotonin in Psychiatric Disorders
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 197
Special Issue Editor
Interests: social behavior and its serotonergic and hormonal underpinnings; developmental disruption of brain circuits governing social behaviors and motivation; cognitive flexibility
Special Issue Information
Dear Colleagues,
The neurotransmitter and hormone serotonin plays many modulatory roles in shaping mood, emotional stability, sleep, and our behaviors, both through its effects in the central nervous system and peripheral effects in the gastrointestinal tract and elsewhere in the body. Through numerous autoreceptors and heteroreceptors (from seven different receptor subfamilies), enzymes, and transporters, the serotonin system is among the most tightly regulated in the body. Given this, it is not surprising that serotonin dysregulation is implicated in various psychiatric disorders that occur across the lifespan. While considerable progress has been made since serotonin’s discovery soon after World War II, there is still much to learn to effectively treat psychiatric disorders through targeting and modulation of the serotonin system.
This Special Issue highlights recent advances in our understanding of the molecular, cellular, and physiological mechanisms of serotonin regulation that can underlie psychiatric disorders coming from in vitro and in vivo basic science research. Explorations of novel treatment interventions are featured, from a range of pharmacological, dietary, or environmental approaches.
It aims to foster a deeper understanding of how serotonin regulation in the brain and periphery can affect biomarkers and/or behaviors relevant to psychiatric disorders. We invite you to explore the cutting-edge research presented here, with the goal of advancing knowledge and improving outcomes for people affected by psychiatric disorders across their lifespan.
In this Special Issue, original research articles are welcome. Research areas may include (but are not limited to) the following:
- Manipulating the serotonin system or testing pharmacological, dietary or environmental treatments in animal models of psychiatric disorders.
- Identification of potential biomarkers for various psychiatric conditions.
- In vitro investigations of cellular or molecular mechanisms of serotonergic regulation by pathological conditions and/or novel treatments.
- Age-dependent effects or targeting the serotonin system in animals or in vitro.
I look forward to receiving your contributions.
Dr. Georgianna Gould
Guest Editor
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Keywords
- diet
- drug treatments
- enzymes
- epigenetic
- post translational modification
- serotonin metabolism
- serotonin receptors
- serotonin transporters
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