Advanced Scaffolds and Tissue Engineering Innovations

Dear Colleagues,

This Special Issue, “Advanced Scaffolds and Tissue Engineering Innovations,” will highlight emerging strategies that integrate biomaterials science, bioengineering, cell biology, and regenerative medicine to address current challenges in tissue repair and regeneration. Advanced scaffolds have evolved beyond passive structural supports into dynamic, biomimetic platforms that regulate cellular behavior, deliver therapeutic factors, and create favorable microenvironments for tissue formation. This issue will explore innovative scaffold architectures, including three-dimensional porous structures, nanofibrous matrices, hydrogels, decellularized extracellular matrices, and hybrid and composite biomaterials designed to reproduce key biochemical and mechanical features of native tissues.

Particular emphasis will be placed on 3D bioprinting, biofabrication, and emerging manufacturing technologies that enable precise control over scaffold geometry, spatial organization, vascularization, and cellular distribution. Contributions addressing smart and stimuli-responsive scaffolds, controlled drug and growth-factor delivery, extracellular-vesicle-based approaches, and immunomodulatory biomaterials are also encouraged. These technologies offer new opportunities to improve cell survival, promote tissue integration, and regulate inflammation during regeneration.

The Special Issue will further examine the application of advanced tissue-engineering approaches for bone, cartilage, skin, nerve, cardiovascular, dental, and other clinically relevant tissues. Studies combining computational modeling, artificial intelligence, materials optimization (e.g., cell or protein interactions), organoid systems, and personalized or patient-specific scaffold design are particularly relevant. Translational research addressing scaffold biocompatibility, biodegradation, mechanical performance, manufacturing reproducibility, sterilization, and regulatory considerations will also be welcomed.

By bringing together interdisciplinary research and perspectives, this Special Issue aims to provide a comprehensive overview of recent advances and future directions in scaffold-based tissue engineering. It will serve as a platform for researchers to present innovative materials, fabrication strategies, mechanistic insights, and translational solutions that can accelerate the development of next-generation regenerative therapies and move tissue-engineering technologies closer to clinical application.

Sincerely,

Prof. Dr. R.D.K. Misra
Guest Editor

Dr. Wisam Bukaita
Guest Editor Assistant

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