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Bioengineering
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Bioengineering Strategies for Ophthalmic Diseases—2nd Edition
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Bioengineering Strategies for Ophthalmic Diseases—2nd Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 March 2027 | Viewed by 482

Editor

Prof. Dr. Jae Yong Kim

E-Mail Website
Guest Editor
Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
Interests: ophthalmology; cataract surgery; cornea
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue "Bioengineering Strategies for Ophthalmic Diseases" explores the latest advancements, trends, and innovations in the field of ophthalmology. It aims to provide a comprehensive overview of the recent developments in diagnostic tools, therapeutic approaches, and techniques for various ophthalmic diseases.

This Special Issue begins by discussing the recent progress in the diagnosis of ophthalmic diseases, including advancements in imaging technology, genetic testing, and biomarker identification. It explores novel diagnostic approaches that enable earlier detection and a more accurate assessment of disease progression.

This Special Issue highlights the latest therapeutic approaches for ophthalmic diseases, ranging from traditional pharmacotherapy to emerging modalities such as gene therapy, bioengineered corneal implants, retinal prostheses, and sustained-release drug delivery systems. It emphasizes the development of targeted therapies and personalized treatment strategies, based on specific disease subtypes.

It also addresses the integration of artificial intelligence (AI) and machine learning in ophthalmology, including AI-based algorithms for disease classification, automated image analysis, and predictive modeling.

Overall, this Special Issue aims to provide insights into the recent advances and trends in ophthalmic disease treatment and future directions in bioengineered therapies for ophthalmic diseases.

Prof. Dr. Jae Yong Kim
Guest Editor

Basanta Bhujel
Guest Editor Assistant
E-mail:
Affiliation: Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
Interests: ophthalmology; cataract surgery; cornea

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ophthalmic diseases
  • imaging technology
  • artificial intelligence
  • retinal regeneration
  • corneal implants
  • drug delivery

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Related Special Issue

Published Papers (1 paper)

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Review

21 pages, 1557 KB  
Review
Retinal Challenges in Sickle Cell Patients—Present and Future: A Systematic Review
by Elie Motulsky and Amina El Bachti
Bioengineering 2026, 13(8), 867; https://doi.org/10.3390/bioengineering13080867 - 27 Jul 2026
Viewed by 171
Abstract
Importance: Sickle cell retinopathy and maculopathy are frequent but underdiagnosed complications of sickle cell disease that can lead to vision loss. Unfortunately, there is currently no ophthalmological follow-up protocol to best diagnose and treat these complications. Objective: To identify the most important risk [...] Read more.
Importance: Sickle cell retinopathy and maculopathy are frequent but underdiagnosed complications of sickle cell disease that can lead to vision loss. Unfortunately, there is currently no ophthalmological follow-up protocol to best diagnose and treat these complications. Objective: To identify the most important risk factors associated with the progression of sickle cell retinopathy and maculopathy, review the current screening techniques and effective treatments and propose a follow-up protocol tailored to the patient’s risk profile. Evidence Review: Relevant studies were selected using the PICO framework and a structured search strategy across multiple databases including PubMed, Scopus, Cochrane Library, Cible+, ScienceDirect and the American Academy of Ophthalmology network. The search spanned from 1980 to 2025. Original research articles addressing risk factors, screening, and treatment methods for sickle cell retinopathy and maculopathy were included. In total, 48 studies met the inclusion criteria. Data extraction and quality assessment were applied uniformly. Findings: The systematic review included 48 articles (10,543 participants), representing a mix of study types: randomized clinical trials, prospective and retrospective cohort studies, and cross-sectional studies. Major findings included: Risk Factors: Commonly identified risk factors for sickle cell retinopathy and maculopathy include genotype SS, increased age, male sex, and low fetal hemoglobin levels. Screening and Diagnosis: Wide-field fluorescein angiography and optical coherence tomography angiography were the most effective tools for early detection of peripheral ischemia and macular thinning, respectively. Treatment and Management: Laser photocoagulation remains the standard intervention for proliferative sickle cell retinopathy. Preventive strategies and regular ophthalmologic monitoring are emphasized across high-quality studies. Conclusions and Relevance: Risk stratification based on genotype, hemoglobin F levels, and imaging findings allows for tailored ophthalmologic management of patients with sickle cell disease. A structured follow-up protocol is proposed, aiming to improve early detection, prevent complications, and optimize resource allocation. Full article
(This article belongs to the Special Issue Bioengineering Strategies for Ophthalmic Diseases—2nd Edition)
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