Heat Shock Proteins in Human Physiology and Pathophysiology

Dear Colleagues,

Heat Shock Proteins are molecular chaperones belonging to the Chaperone System whose expression is typically upregulated under stressful conditions to maintain protein homeostasis (proteostasis).

Traditionally considered cytoprotective molecules, Heat Shock Proteins play a central role in human physiology. However, increasing evidence has revealed their multifaceted nature, showing that they may also contribute to the onset and progression of a broad spectrum of diseases (i.e., chaperonopathies).

Consequently, based on the biological context, Heat Shock Proteins could serve as diagnostic and prognostic biomarkers for evaluating the progression of disease and the response to treatments, as well as therapeutic agents and molecular targets for novel treatment strategies.

This Special Issue aims to explore the complex and controversial role of Heat Shock Proteins, providing an updated and interdisciplinary overview of their involvement in both human physiology and pathophysiology. We welcome the submission of reviews, experimental in vitro or in vivo studies, as well as articles based on novel in silico and computational approaches. We believe that the integration of these complementary methodologies may contribute to a deeper understanding of the molecular mechanisms underlying Heat Shock Proteins’ function in health and disease.

We look forward to receiving your valuable submissions to stimulate discussion in this interesting area of research.

Dr. Alessandra Maria Vitale
Dr. Federica Scalia
Dr. Giuseppa D’Amico
Guest Editors

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