Oxidative Stress in the Development of Inflammatory Chronic Disease

Dear Colleagues,

Over the past few decades, the term oxidative stress has been buzzing around the scientific community. Consequently, oxidative stress has been investigated using many different experimental models that range from molecular studies at the bench to clinical studies by the bedside. An important mediator of oxidative stress is inflammation. However, the fundamental question still exists: What comes first, oxidative stress or inflammation?

Lung diseases (i.e., Chronic obstructive lung disease (COPD), cystic fibrosis (CF), asthma, etc.), clinical pathologies that are traditionally thought to impact the lungs, are associated with both inflammatory and oxidative stress phenotypes. Interestingly, however, these “lung” diseases manifest into many different systemic consequences (i.e., cardiovascular disease, vascular dysfunction, muscle wasting, etc.) which are likely mediated by the interaction between systemic inflammation and oxidative stress. It is noteworthy that, within this complex interaction of multiple pathways, many different systems will be impacted. In general, this special issue published in Antioxidants will focus on oxidative stress in the context of inflammatory diseases. Insight into the relationship between inflammation and oxidative stress on many different scientific outcomes will be sought.

Dr. Ryan A. Harris
Guest Editor

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• oxidative stress
• antioxidants
• chronic obstructive lung disease
• cystic fibrosis
• endothelial function
• lung function
• nitric oxide bioavailability