Targeting Mitochondrial Dysfunction and Oxidative Stress for Neuroprotection

Dear Colleagues,

The incidence of neurodegenerative diseases is increasing worldwide and represents a growing burden to global health. This is particularly apparent for Alzheimer’s disease and related dementias and Parkinson’s disease, but rarer neurodegenerative conditions also have significant impacts on quality of life. Yet treatment options for neurodegenerative conditions remain limited, with no cures and few therapeutic options available.

Many neurodegenerative diseases share several common characteristics, including increased mitochondrial dysfunction and oxidative stress. In fact, these changes are evident early in many neurodegenerative conditions and therefore may offer opportunities to alter disease progression.

The goal of this Special Issue is to bring together research focusing on the therapeutic potential of targeting mitochondrial dysfunction and oxidative stress. Researchers are invited to submit original research articles and review articles related to, but not limited to, the following topics:

• Mechanisms underlying oxidative stress and mitochondrial dysfunction-mediated neurodegeneration.
• Therapeutic interventions targeting improving antioxidant response and mitochondrial function.
• Evaluating markers of oxidative stress and mitochondrial dysfunction as relevant biomarkers for diagnosis or therapeutic target engagement.

Clinical, animal and in vitro work are all appropriate for this issue. The research included in this issue will further our understanding of how mitochondrial dysfunction and oxidative stress contribute to neurodegeneration and how targeting these processes could lead to novel treatments for neurodegenerative diseases.

Dr. Nora Gray
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.