Developing high-response, low-cost H2 sensors is critical for real-time H2 monitoring in the new energy era. In this work, ultra-low content (0.07 wt%) single-atom Pt-loaded SnO2/MEMS H2 sensors were prepared by an extended two-step annealing method,...
This study shows that the structural features of humic acids reflect the specific characteristics of organic matter in permafrost soils of the southern Vitim Plateau. The region’s extracontinental climate determines the rate of decomposition, t...
The present contribution proposes a new design for adsorptive microextraction devices that promote a user-friendly and greener analytical approach. Novel Sorbent Strip Microextraction (SSμE) devices were made using a flexible adhesive film coated...
Biodiesel is a biofuel commonly produced through transesterification, also known as alcoholysis. In this process, triglycerides react with short-chain alcohols (alkyl–OH), producing a mixture of fatty acid esters and glycerol. These esters and...
Myrciaria tenella (cambuí) is a native Brazilian fruit traditionally recognized for its sensory attributes and medicinal properties, including antidiabetic, anti-inflammatory, antimicrobial, and gastroprotective activities. This study evaluate...
Enzymatic cascades, defined here as multi-enzymatic sequences operating on a shared reaction pathway and inspired by the spatial and temporal organization of metabolism, have emerged as powerful and versatile tools for sustainable organic synthesis....
Gut microbial β-glucuronidase (GUS) plays a pivotal role at the microbiota—host interface by hydrolyzing glucuronide conjugates, thereby influencing xenobiotic metabolism, enterohepatic circulation, and systemic homeostasis. Dysregulated G...
The induction of chirality to obtain enantiopure products of high synthetic value is of great importance across various scientific fields, particularly in the medical area, as it has been demonstrated that the different enantiomers of drugs interact...
Propolis is a rich natural source of biologically active polyphenols; however, their therapeutic potential is often limited by poor oral bioaccessibility and bioavailability. This study reports the development and validation of a high-performance liq...
[99mTc]sestamibi ([99mTc][Tc(MIBI)6]+; MIBI = 2-methoxybutylisonitrile) is a clinically established myocardial perfusion SPECT tracer. Its one-pot kit-based synthesis from [99mTc]pertechnetate ([99mTc][TcO4]−) is complex, involving a 6-oxidatio...
High-entropy fluorite oxides offer exceptional tunability of structure and functionality through controlled multi-cation substitution. In this work, Ce-Zr-Pr-Sm-Eu-based high-entropy oxides, with systematically varied Pr content, were synthesized usi...
Glioblastoma, with a 5-year survival rate of just under 7.0%, is the most common form of brain cancer in adults. In this study, we evaluated the antiproliferative activity of the biopolymer p21-ELP1-Bac, a p21-derived peptide delivered via an elastin...
A new series of tacrine–coumarin hybrids (compounds 15a–18b) linked by 1,2,3-triazole had been designed and synthesized as multifunctional ligands for the treatment of Alzheimer’s disease (AD). The inhibitory effects of the synthesi...
Hyperuricemia affects approximately 20% of the global adult population and serves as the primary etiological factor for gout. Glucose transporter 9 (GLUT9) plays a critical role in renal urate reabsorption, representing a promising therapeutic target...
Thermal oxidation of edible oils during high-temperature cooking produces complex fumes containing harmful volatile compounds. However, the role of water, a common co-reactant in practical cooking, remains insufficiently understood. In this study, ol...
Interest in alternative protein sources has grown, with Spirulina, a microalga belonging to the genus Limnospira (formerly Arthrospira), emerging as a key option. Guided by sustainability principles, this study explored the gelling capacity and hydro...
Cubane-1,4-dicarboxylic acid is a key intermediate in the synthesis of the Platonic solid, cubane. While cubane has been extensively studied, its precursor has not. Here, we provide a comprehensive characterization of the vibrational spectra (infrare...
Electromagnetic shielding (EMS) materials play an important role in modern technology and industry, especially in electronic equipment, communication technology, military applications and so on. With the continuous progress of technologies and the in...
The use of metal-based species bearing existing pharmaceuticals as ligands—often resulting in enhanced bioactivity—represents an attractive strategy for the development of novel therapeutic formulations. In this context, five well-known n...
The annual output of Moutan Cortex is significant, but the epidermis of the root bark of peony (EPRP), as a by-product of Moutan Cortex, is typically discarded. To achieve full use of resources, this study aimed to develop an HPLC fingerprint analysi...
In addition to well-known traditional synthetic illicit drugs like cocaine, amphetamines, and heroin, an increasing number of new psychoactive substances (NPS) are appearing on the global drug market. Among them, cathinones represent a prominent clas...
This study presents the development of an environmentally benign and economically viable methodology for the synthesis of graphene-containing carbon materials derived from renewable agricultural residues, specifically walnut shells, rice husks, and a...
The protein kinase N family belongs to the AGC kinase group and contains three isozymes: PKN1, PKN2, and PKN3. Catalytic domains of PKNs share high sequence similarity, yet the proteins differ in tissue distribution, functions, and involvement in pat...
The aim of the present study was to characterize the phenolic profile of hydroethanolic (EAEE) and ethyl acetate (EAAE) extracts of Echium asperrimum and to evaluate their antibacterial, antioxidant, anti-Alzheimer-related (cholinesterase inhibitory)...
The aim of this study was to obtain and characterize grape seed extract and to demonstrate its potential immunomodulatory properties in the autoimmune disease systemic lupus erythematosus (SLE). A Syrah grape seed extract was obtained using 70% aqueo...
Bromodomain-containing protein 9 (BRD9) belongs to the non-canonical BAF chromatin remodeling complex and represents a relevant therapeutic target in pathologies featuring dysregulated epigenetic control. The absence of clinically validated inhibitor...
Cyclodextrins (CDs) are cyclic oligosaccharides composed of α(1 → 4) linked glucose units, which are widely used as solubilizers and stabilizers in the food, pharmaceutical and cosmetic industries. Among the CDs, γ-CD has attracted m...
Microextraction Technologies (METs) have emerged as pivotal exposomic sensors for the on-site monitoring of Volatile Organic Compounds (VOCs) in ambient air. By integrating sampling and sample preparation into a single step, METs provide solvent-free...
Carvone-rich essential oils (EOs), and carvone specifically, exhibit a broad spectrum of protective effects against major agricultural threats. They display strong antifungal and moderate antibacterial effects, effectively inhibiting numerous phytopa...
Trichilia dregeana has a rich phytochemical diversity and biological activity; however, information on its metabolomic profile and antimycotoxigenic potential is limited. This study investigated different extracts of T. dregeana bark obtained with va...
We herein demonstrate that the thiosemicarbazone (TSC) ligand N’-(di(pyridin-2-yl)methylene)-4-(thiazol-2-yl)piperazine-1-carbothiohydrazide (HL) can coordinate with Ga3+ to give cationic complex [Ga(L)2]NO3 featuring an octahedral Ga(III) cent...
Obtaining water-soluble palladium complexes capable of interacting with DNA is an important synthetic task in medicinal chemistry. The interaction of [Pd(phen)(OAc)2] (phen = 1,10-phenanthroline) with pivalic acid (ᵗBuCOOH) and trifluoromethane...
This study investigates the exothermic effects and viscosity properties of multicomponent oxide melts during the high-temperature reduction of low-grade Cr–Mn ores. Unlike previous thermodynamic-focused research, this work provides experimental...
This study details the synthesis, characterization, molecular docking and preliminary biological evaluation of a new heterocyclic compound, 2-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)benzaldehyde. This molecule was designed using an artificial intell...
New diarylheptene polyphenols with α-glucosidase inhibitory activity were previously isolated and reported from the aquatic plant Ottelia acuminata var. acuminata. It was used as the template in the present research, and a series of 1,3-bisbenz...
Arapaima gigas growth hormone (ag-GH) cDNA was previously cloned from A. gigas pituitaries. In this work ag-GH has been synthesized using human embryonic kidney 293 cells (HEK293) transiently transfected with the 3.4-TOPO® vector carrying ag-GH c...
Auranofin, a gold(I)-based compound initially developed for the treatment of rheumatoid arthritis, has emerged as a promising anticancer agent with a multimodal mechanism of action. This review comprehensively examines the therapeutic potential of au...
Accurate quantification in LC–MS experiments becomes challenging when analytes overlap both chromatographically and in mass spectra, as conventional extracted ion chromatogram-based methods can yield biased results by double-counting shared iso...
This study describes a single-laboratory validation of an ultra-high-performance liquid chromatographic (UHPLC) method for the determination of key compounds like hericenones, hericenes, erinacines, and ergosterol in Hericium erinaceus (H. erinaceus,...
Bamboo powder waste generated from bamboo processing serves as an ideal feedstock for biochar (BC). This study employed potassium hydroxide (KOH) to modify biochar derived from bamboo powder waste, activating it at different temperatures (700 °C,...
The global challenge of antimicrobial resistance (AMR) has been framed primarily in terms of genetic resistance mechanisms. Nevertheless, bacteria can also survive antimicrobial stress through phenotypic plasticity, resulting in transient, non-geneti...
Hydrogen energy has garnered widespread attention as a clean energy source. This study employs density functional theory (DFT) to systematically investigate the hydrogen storage performance of Ben(n = 10–12) clusters. The results reveal that ho...
Background: Glioblastoma Multiforme (GBM) is one of the most aggressive primary brain tumors, with a median survival of only 15–17 months. Treatment failure is largely driven by the Blood–Brain Barrier (BBB), which restricts the delivery...
This study provides a phytochemical characterization of Sambucus nigra L. (elderflower) and correlates its chemical profile with anti-inflammatory bioactivity, establishing an optimized extraction methodology. A comparative analysis of ultrasound-ass...
Understanding the competitive adsorption mechanism is crucial for the rational design of CO2 adsorbents. In this work, the surface of zeolite 5A was modified with varying concentrations of n-octadecylphosphonic acid (ODPA) to enhance the adsorptive s...
Accelerated solvent extraction (ASE) is widely used for recovering bioactive compounds from hops; however, the extent to which global antioxidant assays reflect changes in molecular composition remains unclear. This study evaluated the relationship b...
Chestnut shells are widely recognized as a source of bioactive compounds, including polyphenols and other antioxidant molecules. The industrial chestnut food chain generates large amounts of this by-product, which represents both a waste disposal cha...
The unfolded protein response (UPR) is a highly conserved adaptive mechanism that restores endoplasmic reticulum (ER) homeostasis under stress. Beyond its canonical roles in proteostasis, the UPR has emerged as a central regulator of immune responses...
Photosensitizers are susceptible to interference from the biological internal environment, which largely restricts the clinical application of photodynamic therapy. For instance, most existing photosensitizers tend to aggregate in the biological envi...
Cordyceps cicadae, a medicinal and edible entomopathogenic fungus, has been widely used in traditional Chinese medicine for treating various ailments. This study aimed to validate its ethnopharmacological uses by investigating bioactive constituents...
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