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Most Cited

  • Review
  • Open Access
662 Citations
83,662 Views
32 Pages

Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment

  • Satish Sharma,
  • James Mohler,
  • Supriya D. Mahajan,
  • Stanley A. Schwartz,
  • Liana Bruggemann and
  • Ravikumar Aalinkeel

Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to nosocomial, chronic infections in clinical settings. Since the bacter...

  • Review
  • Open Access
285 Citations
29,810 Views
16 Pages

Plant Growth-Promoting Rhizobacteria for Sustainable Agricultural Production

  • Luana Alves de Andrade,
  • Carlos Henrique Barbosa Santos,
  • Edvan Teciano Frezarin,
  • Luziane Ramos Sales and
  • Everlon Cid Rigobelo

Rhizosheric bacteria with several abilities related to plant growth and health have been denominated Plant Growth-Promoting Rhizobacteria (PGPR). PGPR promote plant growth through several modes of action, be it directly or indirectly. The benefits pr...

  • Review
  • Open Access
279 Citations
50,203 Views
17 Pages

Biological Degradation of Plastics and Microplastics: A Recent Perspective on Associated Mechanisms and Influencing Factors

  • Zeming Cai,
  • Minqian Li,
  • Ziying Zhu,
  • Xiaocui Wang,
  • Yuanyin Huang,
  • Tianmu Li,
  • Han Gong and
  • Muting Yan

Plastic and microplastic pollution has caused a great deal of ecological problems because of its persistence and potential adverse effects on human health. The degradation of plastics through biological processes is of great significance for ecologic...

  • Review
  • Open Access
243 Citations
90,065 Views
29 Pages

The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties

  • Nicoleta-Maricica Maftei,
  • Cosmin Raducu Raileanu,
  • Alexia Anastasia Balta,
  • Lenuta Ambrose,
  • Monica Boev,
  • Denisa Batîr Marin and
  • Elena Lacramioara Lisa

Probiotics, known to be live microorganisms, have been shown to improve or restore the gut microbiota, which in turn has been linked to improved health. It is believed that probiotics are the modern equivalent of a panacea, with claims that they may...

  • Review
  • Open Access
178 Citations
24,636 Views
35 Pages

Antimicrobial Drug Resistance in Poultry Production: Current Status and Innovative Strategies for Bacterial Control

  • Raquel Abreu,
  • Teresa Semedo-Lemsaddek,
  • Eva Cunha,
  • Luís Tavares and
  • Manuela Oliveira

The world population’s significant increase has promoted a higher consumption of poultry products, which must meet the specified demand while maintaining their quality and safety. It is well known that conventional antimicrobials (antibiotics)...

  • Review
  • Open Access
160 Citations
23,399 Views
21 Pages

Desulfovibrio in the Gut: The Enemy within?

  • Sudha B. Singh,
  • Amanda Carroll-Portillo and
  • Henry C. Lin

Desulfovibrio (DSV) are sulfate-reducing bacteria (SRB) that are ubiquitously present in the environment and as resident commensal bacteria within the human gastrointestinal tract. Though they are minor residents of the healthy gut, DSV are opportuni...

  • Review
  • Open Access
155 Citations
35,649 Views
20 Pages

Despite the recent advances in food preservation techniques and food safety, significant disease outbreaks linked to foodborne pathogens such as bacteria, fungi, and viruses still occur worldwide indicating that these pathogens still constitute signi...

  • Review
  • Open Access
154 Citations
20,190 Views
32 Pages

Antimicrobial Resistance in the Global Health Network: Known Unknowns and Challenges for Efficient Responses in the 21st Century

  • Teresa M. Coque,
  • Rafael Cantón,
  • Ana Elena Pérez-Cobas,
  • Miguel D. Fernández-de-Bobadilla and
  • Fernando Baquero

Antimicrobial resistance (AMR) is one of the Global Health challenges of the 21st century. The inclusion of AMR on the global map parallels the scientific, technological, and organizational progress of the healthcare system and the socioeconomic chan...

  • Review
  • Open Access
154 Citations
16,402 Views
32 Pages

Silver Nanoparticles: Review of Antiviral Properties, Mechanism of Action and Applications

  • Angelica Luceri,
  • Rachele Francese,
  • David Lembo,
  • Monica Ferraris and
  • Cristina Balagna

New antiviral drugs and new preventive antiviral strategies are a target of intense scientific interest. Thanks to their peculiar properties, nanomaterials play an important role in this field, and, in particular, among metallic materials, silver nan...

  • Review
  • Open Access
151 Citations
18,870 Views
22 Pages

Phosphorus is an essential nutrient for all life on earth and has a major impact on plant growth and crop yield. The forms of phosphorus that can be directly absorbed and utilized by plants are mainly HPO42− and H2PO4, which are known as...

  • Review
  • Open Access
142 Citations
43,755 Views
47 Pages

The Evolving Microbiome of Dental Caries

  • Grace Spatafora,
  • Yihong Li,
  • Xuesong He,
  • Annie Cowan and
  • Anne C. R. Tanner

Dental caries is a significant oral and public health problem worldwide, especially in low-income populations. The risk of dental caries increases with frequent intake of dietary carbohydrates, including sugars, leading to increased acidity and disru...

  • Review
  • Open Access
138 Citations
30,162 Views
27 Pages

Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies

  • Syamily Shaji,
  • Ramesh K. Selvaraj and
  • Revathi Shanmugasundaram

Salmonella is the leading cause of food-borne zoonotic disease worldwide. Non-typhoidal Salmonella serotypes are the primary etiological agents associated with salmonellosis in poultry. Contaminated poultry eggs and meat products are the major source...

  • Review
  • Open Access
138 Citations
14,893 Views
26 Pages

The Recent Advances in the Utility of Microbial Lipases: A Review

  • Sajid Ali,
  • Sumera Afzal Khan,
  • Muhammad Hamayun and
  • In-Jung Lee

Lipases are versatile biocatalysts and are used in different bioconversion reactions. Microbial lipases are currently attracting a great amount of attention due to the rapid advancement of enzyme technology and its practical application in a variety...

  • Review
  • Open Access
137 Citations
31,833 Views
21 Pages

Microorganisms rule the functioning of our planet and each one of the individual macroscopic living creature. Nevertheless, microbial activity and growth status have always been challenging tasks to determine both in situ and in vivo. Microbial activ...

  • Review
  • Open Access
131 Citations
33,857 Views
51 Pages

An Overview of the Recent Advances in Antimicrobial Resistance

  • Manuela Oliveira,
  • Wilson Antunes,
  • Salete Mota,
  • Áurea Madureira-Carvalho,
  • Ricardo Jorge Dinis-Oliveira and
  • Diana Dias da Silva

Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires a comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by its...

  • Review
  • Open Access
131 Citations
29,315 Views
28 Pages

Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs are designed not only for conventional use as foods or dietary supplements but are also tailored for p...

  • Review
  • Open Access
127 Citations
50,988 Views
37 Pages

Oral Microbiome: A Review of Its Impact on Oral and Systemic Health

  • John J. Rajasekaran,
  • Hari Krishnan Krishnamurthy,
  • Jophi Bosco,
  • Vasanth Jayaraman,
  • Karthik Krishna,
  • Tianhao Wang and
  • Kang Bei

Purpose of review: This review investigates the oral microbiome’s composition, functions, influencing factors, connections to oral and systemic diseases, and personalized oral care strategies. Recent findings: The oral microbiome is a complex e...

  • Review
  • Open Access
123 Citations
21,662 Views
31 Pages

Exopolysaccharides Producing Bacteria: A Review

  • Alexander I. Netrusov,
  • Elena V. Liyaskina,
  • Irina V. Kurgaeva,
  • Alexandra U. Liyaskina,
  • Guang Yang and
  • Viktor V. Revin

Bacterial exopolysaccharides (EPS) are essential natural biopolymers used in different areas including biomedicine, food, cosmetic, petroleum, and pharmaceuticals and also in environmental remediation. The interest in them is primarily due to their u...

  • Review
  • Open Access
119 Citations
30,788 Views
32 Pages

Urinary tract infections (UTIs) are among the most common bacterial infections, especially among women and older adults, leading to a significant global healthcare cost burden. Uropathogenic Escherichia coli (UPEC) are the most common cause and accou...

  • Review
  • Open Access
118 Citations
21,028 Views
27 Pages

A Review on Colistin Resistance: An Antibiotic of Last Resort

  • Aftab Hossain Mondal,
  • Kriti Khare,
  • Prachika Saxena,
  • Parbati Debnath,
  • Kasturi Mukhopadhyay and
  • Dhananjay Yadav

Antibiotic resistance has emerged as a significant global public health issue, driven by the rapid adaptation of microorganisms to commonly prescribed antibiotics. Colistin, previously regarded as a last-resort antibiotic for treating infections caus...

  • Review
  • Open Access
111 Citations
17,018 Views
14 Pages

Biosynthetic Pathways and Functions of Indole-3-Acetic Acid in Microorganisms

  • Jintian Tang,
  • Yukang Li,
  • Leilei Zhang,
  • Jintao Mu,
  • Yangyang Jiang,
  • Huilan Fu,
  • Yafen Zhang,
  • Haifeng Cui,
  • Xiaoping Yu and
  • Zihong Ye

Indole-3-acetic acid (IAA) belongs to the family of auxin indole derivatives. IAA regulates almost all aspects of plant growth and development, and is one of the most important plant hormones. In microorganisms too, IAA plays an important role in gro...

  • Review
  • Open Access
111 Citations
18,578 Views
17 Pages

Outer Membrane Porins Contribute to Antimicrobial Resistance in Gram-Negative Bacteria

  • Gang Zhou,
  • Qian Wang,
  • Yingsi Wang,
  • Xia Wen,
  • Hong Peng,
  • Ruqun Peng,
  • Qingshan Shi,
  • Xiaobao Xie and
  • Liangqiu Li

Gram-negative bacteria depend on their cell membranes for survival and environmental adaptation. They contain two membranes, one of which is the outer membrane (OM), which is home to several different outer membrane proteins (Omps). One class of impo...

  • Review
  • Open Access
110 Citations
23,709 Views
26 Pages

Matrix-Assisted Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) in the last decade has revealed itself as a valid support in the workflow in the clinical microbiology laboratory for the identification of bacteria and fungi, demo...

  • Review
  • Open Access
104 Citations
19,948 Views
14 Pages

Lactobacillus Bacteremia and Probiotics: A Review

  • Ravina Kullar,
  • Ellie J. C. Goldstein,
  • Stuart Johnson and
  • Lynne V. McFarland

Lactobacilli are widely found in nature, are commensal microbes in humans, and are commonly used as probiotics. Concerns about probiotic safety have arisen due to reports of bacteremia and other Lactobacillus-associated infections. We reviewed the li...

  • Review
  • Open Access
101 Citations
9,434 Views
25 Pages

The Silent Threat: Antimicrobial-Resistant Pathogens in Food-Producing Animals and Their Impact on Public Health

  • Ayidh M. Almansour,
  • Meshari A. Alhadlaq,
  • Khaloud O. Alzahrani,
  • Lenah E. Mukhtar,
  • Abdulmohsen L. Alharbi and
  • Sulaiman M. Alajel

The emergence of antimicrobial resistance (AMR) is a global health problem without geographic boundaries. This increases the risk of complications and, thus, makes it harder to treat infections, which can result in higher healthcare costs and a great...

  • Review
  • Open Access
99 Citations
14,388 Views
16 Pages

The Role of Fusobacterium nucleatum in Oral and Colorectal Carcinogenesis

  • Pamela Pignatelli,
  • Federica Nuccio,
  • Adriano Piattelli and
  • Maria Cristina Curia

In recent years, several studies have suggested a strong association of microorganisms with several human cancers. Two periodontopathogenic species in particular have been mentioned frequently: Fusobacterium nucleatum (F. nucleatum) and Porphyromonas...

  • Review
  • Open Access
98 Citations
11,748 Views
23 Pages

Plant health is necessary for food security, which is a key determinant of secure and sustainable food production systems. Deficiency of soil nutrients and invasion of plant pathogens or insects are the main destroyers of the world’s food produ...

  • Review
  • Open Access
98 Citations
30,945 Views
52 Pages

Current Insights in Fungal Importance—A Comprehensive Review

  • Viorica Maria Corbu,
  • Irina Gheorghe-Barbu,
  • Andreea Ștefania Dumbravă,
  • Corneliu Ovidiu Vrâncianu and
  • Tatiana Eugenia Șesan

Besides plants and animals, the Fungi kingdom describes several species characterized by various forms and applications. They can be found in all habitats and play an essential role in the excellent functioning of the ecosystem, for example, as decom...

  • Review
  • Open Access
97 Citations
48,569 Views
19 Pages

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the gastric mucosa and is associated with various gastrointestinal disorders. H. pylori is a pervasive pathogen, infecting nearly 50% of the world’s population, and pre...

  • Review
  • Open Access
92 Citations
17,349 Views
26 Pages

Infectious disease outbreaks have caused thousands of deaths and hospitalizations, along with severe negative global economic impacts. Among these, infections caused by antimicrobial-resistant microorganisms are a major growing concern. The misuse an...

  • Review
  • Open Access
91 Citations
14,709 Views
25 Pages

Application of Encapsulation Strategies for Probiotics: From Individual Loading to Co-Encapsulation

  • Sofia Agriopoulou,
  • Maria Tarapoulouzi,
  • Theodoros Varzakas and
  • Seid Mahdi Jafari

Consumers are increasingly showing a preference for foods whose nutritional and therapeutic value has been enhanced. Probiotics are live microorganisms, and their existence is associated with a number of positive effects in humans, as there are many...

  • Review
  • Open Access
83 Citations
13,274 Views
13 Pages

Bioaugmentation is widely used in soil bioremediation, wastewater treatment, and air biofiltration. The addition of microbial biomass to contaminated areas can considerably improve their biodegradation performance. Nevertheless, analyses of large dat...

  • Review
  • Open Access
83 Citations
8,015 Views
24 Pages

Entomopathogenic Fungi: An Eco-Friendly Synthesis of Sustainable Nanoparticles and Their Nanopesticide Properties

  • Ritu Bihal,
  • Jameel M. Al-Khayri,
  • A. Najitha Banu,
  • Natasha Kudesia,
  • Farah K. Ahmed,
  • Rudradeb Sarkar,
  • Akshit Arora and
  • Kamel A. Abd-Elsalam

The agricultural industry could undergo significant changes due to the revolutionary potential of nanotechnology. Nanotechnology has a broad range of possible applications and advantages, including insect pest management using treatments based on nan...

  • Review
  • Open Access
77 Citations
30,497 Views
17 Pages

The skin microbiota is a pivotal contributor to the maintenance of skin homeostasis by protecting it from harmful pathogens and regulating the immune system. An imbalance in the skin microbiota can lead to pathological conditions such as eczema, psor...

  • Article
  • Open Access
76 Citations
19,929 Views
19 Pages

Microorganisms for Bioremediation of Soils Contaminated with Heavy Metals

  • Victor V. Atuchin,
  • Lyudmila K. Asyakina,
  • Yulia R. Serazetdinova,
  • Anna S. Frolova,
  • Natalia S. Velichkovich and
  • Alexander Yu. Prosekov

Heavy-metal contaminants are one of the most relevant problems of contemporary agriculture. High toxicity and the ability to accumulate in soils and crops pose a serious threat to food security. To solve this problem, it is necessary to accelerate th...

  • Review
  • Open Access
72 Citations
11,478 Views
18 Pages

Electroactive bacteria (EAB) are natural microorganisms (mainly Bacteria and Archaea) living in various habitats (e.g., water, soil, sediment), including extreme ones, which can interact electrically each other and/or with their extracellular environ...

  • Review
  • Open Access
72 Citations
20,874 Views
69 Pages

Periodontal diseases and dental caries are the most common infectious oral diseases impacting oral health globally. Oral cavity health is crucial for enhancing life quality since it serves as the entranceway to general health. The oral microbiome and...

  • Review
  • Open Access
72 Citations
25,560 Views
30 Pages

The Impact of Immune System Aging on Infectious Diseases

  • Eugenia Quiros-Roldan,
  • Alessandra Sottini,
  • Pier Giorgio Natali and
  • Luisa Imberti

Immune system aging is becoming a field of increasing public health interest because of prolonged life expectancy, which is not paralleled by an increase in health expectancy. As age progresses, innate and adaptive immune systems undergo changes, whi...

  • Review
  • Open Access
72 Citations
12,889 Views
28 Pages

Microbial Biofilms: Applications, Clinical Consequences, and Alternative Therapies

  • Asghar Ali,
  • Andaleeb Zahra,
  • Mohan Kamthan,
  • Fohad Mabood Husain,
  • Thamer Albalawi,
  • Mohammad Zubair,
  • Roba Alatawy,
  • Mohammad Abid and
  • Md Salik Noorani

Biofilms are complex communities of microorganisms that grow on surfaces and are embedded in a matrix of extracellular polymeric substances. These are prevalent in various natural and man-made environments, ranging from industrial settings to medical...

  • Review
  • Open Access
72 Citations
10,355 Views
16 Pages

The Challenge of Overcoming Antibiotic Resistance in Carbapenem-Resistant Gram-Negative Bacteria: “Attack on Titan”

  • Giuseppe Mancuso,
  • Silvia De Gaetano,
  • Angelina Midiri,
  • Sebastiana Zummo and
  • Carmelo Biondo

The global burden of bacterial resistance remains one of the most serious public health concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients require immediate empirical treatment, which may not only be ineffect...

  • Review
  • Open Access
71 Citations
30,128 Views
15 Pages

Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO

  • Michalina Banaszak,
  • Ilona Górna,
  • Dagmara Woźniak,
  • Juliusz Przysławski and
  • Sławomira Drzymała-Czyż

Gut microbiota is the aggregate of all microorganisms in the human digestive system. There are 1014 CFU/mL of such microorganisms in the human body, including bacteria, viruses, fungi, archaea and protozoa. The Firmicutes and Bacteroidetes bacteria p...

  • Review
  • Open Access
70 Citations
16,288 Views
19 Pages

Bacterial Pigments and Their Multifaceted Roles in Contemporary Biotechnology and Pharmacological Applications

  • Himani Agarwal,
  • Sneh Bajpai,
  • Arti Mishra,
  • Isha Kohli,
  • Ajit Varma,
  • Mireille Fouillaud,
  • Laurent Dufossé and
  • Naveen Chandra Joshi

Synthetic dyes and colourants have been the mainstay of the pigment industry for decades. Researchers are eager to find a more environment friendly and non-toxic substitute because these synthetic dyes have a negative impact on the environment and pe...

  • Review
  • Open Access
69 Citations
7,974 Views
19 Pages

Mechanisms and Applications of Bacterial Inoculants in Plant Drought Stress Tolerance

  • Priscila Pires Bittencourt,
  • Alice Ferreira Alves,
  • Mariana Barduco Ferreira,
  • Luiz Eduardo Souza da Silva Irineu,
  • Vitor Batista Pinto and
  • Fabio Lopes Olivares

Agricultural systems are highly affected by climatic factors such as temperature, rain, humidity, wind, and solar radiation, so the climate and its changes are major risk factors for agricultural activities. A small portion of the agricultural areas...

  • Review
  • Open Access
67 Citations
8,207 Views
29 Pages

Endophytes in Agriculture: Potential to Improve Yields and Tolerances of Agricultural Crops

  • Declan Watts,
  • Enzo A. Palombo,
  • Alex Jaimes Castillo and
  • Bita Zaferanloo

Endophytic fungi and bacteria live asymptomatically within plant tissues. In recent decades, research on endophytes has revealed that their significant role in promoting plants as endophytes has been shown to enhance nutrient uptake, stress tolerance...

  • Review
  • Open Access
66 Citations
8,549 Views
21 Pages

Probiotics for Neurodegenerative Diseases: A Systemic Review

  • Sandhya Ojha,
  • Nil Patil,
  • Mukul Jain,
  • Chittaranjan Kole and
  • Prashant Kaushik

Neurodegenerative disorders (ND) are a group of conditions that affect the neurons in the brain and spinal cord, leading to their degeneration and eventually causing the loss of function in the affected areas. These disorders can be caused by a range...

  • Review
  • Open Access
66 Citations
14,312 Views
34 Pages

Marine biofouling is an undeniable challenge for aquatic systems since it is responsible for several environmental and ecological problems and economic losses. Several strategies have been developed to mitigate fouling-related issues in marine enviro...

  • Review
  • Open Access
66 Citations
12,086 Views
25 Pages

Bacillus Species: Excellent Biocontrol Agents against Tomato Diseases

  • Vasiljka Karačić,
  • Dragana Miljaković,
  • Jelena Marinković,
  • Maja Ignjatov,
  • Dragana Milošević,
  • Gordana Tamindžić and
  • Milan Ivanović

Tomatoes encounter many pathogens, such as fungi and bacteria, which reduce the yield and quality of plants and lead to large losses in production. The application of plant protection products (PPPs) is still an important and most effective measure t...

  • Review
  • Open Access
66 Citations
11,119 Views
19 Pages

Microbially influenced corrosion (MIC) is a formidable challenge in the marine industry, resulting from intricate interactions among various biochemical reactions and microbial species. Many preventions used to mitigate biocorrosion fail due to ignor...

  • Review
  • Open Access
66 Citations
13,280 Views
26 Pages

Tick-Borne Encephalitis Virus: A Comprehensive Review of Transmission, Pathogenesis, Epidemiology, Clinical Manifestations, Diagnosis, and Prevention

  • Emina Pustijanac,
  • Moira Buršić,
  • Jasminka Talapko,
  • Ivana Škrlec,
  • Tomislav Meštrović and
  • Dubravka Lišnjić

Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, can cause serious infection of the central nervous system in humans, resulting in potential neurological complications and fatal outcomes. TBEV is primarily transmitted to hum...

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Microorganisms - ISSN 2076-2607