Cell and Gene Therapy

Cell- and gene-based therapies are transforming human translational medicine. They have redefined our understanding of fundamental cell biology while driving the development of clinically viable interventions for complex and age-related diseases. As these fields mature, engineering the next generation of therapeutics demands greater precision, efficacy, and personalization. This requires overcoming several critical scientific and translational challenges, including:

• Enhancing the physiological and anatomical fidelity of engineered human tissues.
• Maximizing target specificity through precision genetic engineering technologies.
• Resolving barriers to immunity, safety, and durable performance.
• Establishing scalable, cost-effective, and clinically compliant manufacturing processes.
• Developing real time and non-invasive tracking to assess therapeutic responses.

Addressing these multi-dimensional challenges necessitates robust, cross-disciplinary collaboration. The Cell and Gene Therapy Section serves as an ideal forum for the dissemination of high-impact research addressing these critical bottlenecks. This includes pioneering methodologies in emerging domains, such as New Approach Methodologies, to reduce the use of animal models in preclinical research.

We welcome original research, review articles, and communications, on topics including, but not limited to, the following:

1. Advanced Therapeutics and Translational Medicine

• Adoptive Cell and CAR-T/TCR-T Therapies;
• Immunotherapy and Vaccinology;
• Stem Cell Biology and Regenerative Medicine;
• RNA and Genomic Medicine.

2. Genetic Modalities and Delivery Vectors

• Advanced Genome Editing;
• Viral and Non-Viral Vector Engineering;
• Oncolytic Virology;
• Epigenetic Editing,

3. Tissue Engineering

• Biomaterials;
• Tissue Regeneration and Repair;
• Synthetic Biology;
• Preclinical Modelling,

4. Manufacture, Safety, and Tracking

• Administration and Targeting;
• Transplantation;
• Therapeutic Stability;
• Immune Compatibility;
• Non-Invasive and Real Time Monitoring.