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Therapeutics, Volume 3, Issue 1

2026 March - 8 articles

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Articles (8)

  • Article
  • Open Access
1,329 Views
10 Pages

The Use of Human Placental Allografts for Pyoderma Gangrenosum

  • Nicholas Chin,
  • Joel Kallarackal,
  • Jomana Shenouda,
  • Adrianne Pan and
  • Lilia Correa-Selm

Background/Objectives: Pyoderma gangrenosum (PG) is a rapidly progressive, ulcerating condition that can cause large, painful lesions when uncontrolled. There is currently no standard of care treatment for severe PG ulcers refractory to systemic trea...

  • Article
  • Open Access
1,840 Views
11 Pages

Galectin-3 (Gal-3) Inhibitors as Radiosensitizers for Prostate Cancer

  • Renato M. Rodrigues,
  • Bárbara Matos,
  • Vera Miranda-Gonçalves,
  • Carmen Jerónimo and
  • Margarida Fardilha

Introduction: Radioresistance in prostate cancer (PCa) poses a major therapeutic challenge. Galectin-3 (Gal-3) is overexpressed in aggressive PCa and may contribute to resistance mechanisms. This study evaluated the role of Gal-3 in radioresistance a...

  • Review
  • Open Access
3 Citations
2,574 Views
20 Pages

Artificial Intelligence and Precision Pharmacotherapy in Pediatrics: A New Paradigm in Therapeutic Decision-Making

  • Gianluca Mondillo,
  • Alessandra Perrotta,
  • Mariapia Masino,
  • Simone Colosimo and ,
  • Vittoria Frattolillo and
  • Fabio Giovanni Abbate
  • + 1 author+ 0 author

Artificial Intelligence (AI) and Precision Medicine are increasingly influencing pediatric pharmacotherapy, where age-dependent pharmacokinetic variability demands highly individualized therapeutic strategies. This review examines current application...

  • Review
  • Open Access
1 Citations
2,351 Views
22 Pages

Signal Peptide-CUB-EGF-like Domain-Containing Protein 3 (SCUBE3): From Molecule to Therapy

  • Ayooluwa Ilesanmi,
  • Casey Stevens-Washington,
  • Shelby Jones,
  • Karina Alarcon and ,
  • Anush Aryal,
  • Panneerdoss Subbarayalu,
  • Terry J. Shackleford,
  • Davida Crossley and
  • Benjamin C. Onyeagucha
  • + 4 authors+ 0 author

Background: The signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is a secretory protein that plays a role in cancer, cardiovascular, and immune disorders. SCUBE1, SCUBE2, and SCUBE3 belong to the SCUBE family. They contain multiple co...

  • Brief Report
  • Open Access
1,741 Views
7 Pages

Background: Hyponatremia (serum sodium levels below 135 mEq/L) is the most prevalent electrolyte imbalance, with the syndrome of inappropriate antidiuresis (SIAD) being the most common cause among inpatients. Fluid restriction is the primary treatmen...

  • Article
  • Open Access
1 Citations
3,031 Views
13 Pages

The Effect of Pes Planus on Balance Ability in Individuals with Chronic Ankle Instability—A Pilot Study

  • Anna Christakou,
  • Ioannis Kyrosis,
  • Konstantinos Michopoulos,
  • Ioannis Fytanidis and
  • Ioannis Siakabenis

Background/Objectives: Pes planus is characterized by loss of medial longitudinal foot arch, resulting potentially in dysfunction in balance. Chronic ankle instability (CAI) is related to sensorimotor control deficits. Both of these two musculoskelet...

  • Review
  • Open Access
2,664 Views
10 Pages

Fecal Microbiota Transplant in Alcoholic Liver Disease: A Review of Current Literature

  • Alexander Grieme,
  • Yizhong Wu,
  • Kalee Moore,
  • Manuel Garza and ,
  • Eric R. Smith,
  • Erica Yatsynovich,
  • Thomas J. Egeland and
  • Rajesh Shah
  • + 3 authors+ 0 author

Alcohol-associated liver disease, particularly severe alcoholic-associated hepatitis (AH), remains a major cause of morbidity and mortality worldwide. Conventional treatments, including corticosteroids, offer limited short-term benefit and are contra...

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Therapeutics - ISSN 2813-9909