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COVID, Volume 3, Issue 10

2023 October - 9 articles

Cover Story: Given the observed variability in inflammatory responses to SARS-CoV-2 infections, we have developed an in vitro model system (based on monocytes and macrophages) that yielded insights regarding the impact of rs2228145, a clinically relevant polymorphism within a key inflammatory gene in the body’s response to SARS-CoV-2 infections: the interleukin-6 receptor (IL-6R) gene. The treatment of monocytes and macrophages with SARS-CoV-2 spike-protein induced pro-inflammatory IL-6/IL-6R signaling responses whose severity was influenced by the monocyte–macrophage rs2228145 genotype. These findings may aid the future management/treatment of COVID-19 and long COVID, as rs2228145 genotyping may allow the identification of those at risk of severe and/or prolonged symptoms following SARS-COV-2 infection. View this paper
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Articles (9)

  • Article
  • Open Access
2 Citations
3,475 Views
17 Pages

19 October 2023

The ability to adaptively cope with the challenges of stressful events such as the COVID-19 pandemic is crucial for healthy aging. One effective coping strategy is social coping in which social networks are tapped for support. However, our review of...

(This article belongs to the Special Issue COVID and Post-COVID: The Psychological and Social Impact of COVID-19)
  • Article
  • Open Access
1 Citations
2,366 Views
10 Pages

Housing Status and COVID-19 Prevention Recommendations among People Who Use Drugs

  • Izza Zaidi,
  • Ashly E. Jordan,
  • Lauren Jessell,
  • Leonardo Dominguez Gomez,
  • Alex Harocopos and
  • Michelle Nolan

17 October 2023

Housing conditions can increase health risks for people who use opioids (PWUO). Little research documents the influence of housing on PWUO’s ability to practice disease prevention methods. This study examines associations between housing status...

(This article belongs to the Special Issue COVID and Post-COVID: The Psychological and Social Impact of COVID-19)
  • Article
  • Open Access
3 Citations
3,039 Views
11 Pages

Changes in Lifestyle Habits in Individuals with Diabetes during the COVID-19 Pandemic: The ELSA-Brasil Cohort Study

  • William Jones Dartora,
  • Maria Inês Schmidt,
  • Rosane Harter Griep and
  • Bruce B. Duncan

12 October 2023

The COVID-19 pandemic and society’s response to it may have constrained the ability of those with diabetes to achieve a healthy lifestyle. We conducted a longitudinal study to assess the frequency and magnitude of sedentary habits, physical act...

(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities)
  • Review
  • Open Access
3 Citations
3,030 Views
15 Pages

SARS-CoV-2: An Update on the Biological Interplay with the Human Host

  • Giuseppe Lippi,
  • Fabian Sanchis-Gomar,
  • Camilla Mattiuzzi and
  • Brandon M. Henry

10 October 2023

Coronavirus Disease 2019 (COVID-19) is an infectious respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease, first identified in the Chinese city of Wuhan in November 2019, has since spread worldwide,...

  • Article
  • Open Access
6 Citations
3,930 Views
15 Pages

Psychotherapy Incorporating Equine Interaction as a Complementary Therapeutic Intervention for Young Adults in a Residential Treatment Program during the COVID-19 Pandemic

  • Katie Holtcamp,
  • Molly C. Nicodemus,
  • Tommy Phillips,
  • David Christiansen,
  • Brian J. Rude,
  • Peter L. Ryan and
  • Karen Galarneau

4 October 2023

Substance use disorder has become an epidemic in the young adult population across the United States, and these numbers rose during the COVID-19 pandemic. Psychotherapy incorporating equine interaction has emerged to show promise in the mental health...

(This article belongs to the Special Issue COVID and Post-COVID: The Psychological and Social Impact of COVID-19)
  • Article
  • Open Access
1 Citations
5,214 Views
17 Pages

The rs2228145 Variant of the Interleukin-6 Receptor (IL-6R) Gene Impacts on In Vitro Cellular Responses to SARS-CoV-2 VOC B1.1.7 Recombinant Spike Protein

  • Saira Sarwar,
  • Rebecca Aicheler,
  • Lee Butcher,
  • Katie Rees,
  • Stephen Potter,
  • Richard Rowlands and
  • Richard Webb

3 October 2023

Given the variability in inflammatory responses to SARS-CoV-2 infection observed within human populations, we aimed to develop an in vitro model system (based on monocyte-macrophages, a key relevant cell type) that could yield insights regarding the...

(This article belongs to the Special Issue Immune Responses in Coronavirus Disease)
  • Article
  • Open Access
5 Citations
9,332 Views
10 Pages

Perceived Stress and Coping among University Students Amidst COVID-19 Pandemic

  • Coral L. Shuster,
  • Marie C. Tate,
  • Christina T. Schulz,
  • Cheyenne T. Reyes,
  • Megan M. Drohan,
  • Angela G. Astorini,
  • Amy L. Stamates,
  • Manshu Yang and
  • Mark L. Robbins

29 September 2023

University students may have experienced heightened levels of stress during the COVID-19 pandemic; however, less is known about coping mechanisms (i.e., approach and avoidance) that were used to manage such stress. Further, there is a need to identif...

  • Article
  • Open Access
2,974 Views
16 Pages

Research Staff COVID-19 Pandemic Survey-Results from the Prevention and Early Treatment of Acute Lung Injury (PETAL) Network

  • Jasreen Kaur Gill,
  • Andrew Bissonette,
  • Aaron A. Cook,
  • Anja Kathrin Jaehne,
  • Jacqueline Day,
  • Sheri Renaud,
  • Gordon Jacobsen,
  • Kristine Nelson,
  • Lori-Ann Kozikowski and
  • on behalf of the National Heart, Lung and Blood Institute PETAL Clinical Trials Network
  • + 12 authors

23 September 2023

Objectives: There is a lack of knowledge about the challenges of researchers who continued in-person research during the early phases of the COVID-19 pandemic. Design: Electronic survey assessing work-related exposure to COVID-19, logistical challeng...

(This article belongs to the Special Issue COVID and Post-COVID: The Psychological and Social Impact of COVID-19)
  • Review
  • Open Access
24 Citations
46,647 Views
12 Pages

Effectiveness of COVID-19 Vaccination on Transmission: A Systematic Review

  • Anouk Oordt-Speets,
  • Julia Spinardi,
  • Carlos Mendoza,
  • Jingyan Yang,
  • Graciela Morales,
  • John M. McLaughlin and
  • Moe H. Kyaw

23 September 2023

Vaccination against infectious disease affords direct protection from vaccine-induced immunity and additional indirect protection for unvaccinated persons. A systematic review was conducted to estimate the indirect effect of COVID-19 vaccination. Fro...

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COVID - ISSN 2673-8112