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Compounds, Volume 3, Issue 2

2023 June - 6 articles

Cover Story: Substrate screening is a useful approach to identify superior cleavage sequences for drug development and establish rapid screening systems. Beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a target enzyme for Alzheimer’s disease drug development as it triggers amyloid β-peptide (Aβ) production by cleaving the amyloid precursor protein (APP), and Aβs aggregations are thought to play a critical role in Alzheimer’s disease. We investigated BACE1 screening possibilities using synthetic peptides based on the APP sequence. Here, we present peptide libraries that we tested by incubating peptides with BACE1. The digested compounds were analyzed, and peptides were found to contain several effective unnatural amino acid compounds that can be used for future drug design. View this paper
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Articles (6)

  • Article
  • Open Access
4 Citations
3,553 Views
11 Pages

Integrated Analysis by GC/MS and 13C NMR of Moroccan Cladanthus mixtus Essential Oil; Identification of Uncommon Epoxyfarnesanes

  • Souad El Hafidi,
  • Khadija Bakhy,
  • Mohammed Ouhssine,
  • Abderrahim Benzakour and ,
  • Joseph Casanova,
  • Mathieu Paoli and
  • Félix Tomi
  • + 2 authors+ 0 author

17 May 2023

Cladanthus mixtus (L.) Chevall., Asteraceae, also known as Moroccan chamomile, is a spontaneous, annual plant growing wild in North-Western Morocco. Economically, the essential oil of C. mixtus is of high interest, Morocco being the only supplier on...

(This article belongs to the Special Issue Feature Papers in Compounds (2022–2023))
  • Feature Paper
  • Article
  • Open Access
13 Citations
3,874 Views
17 Pages

Interplay between Fe(II) and Fe(III) and Its Impact on Thermoelectric Properties of Iron-Substituted Colusites Cu26−xFexV2Sn6S32

  • Alexey O. Polevik,
  • Alexey V. Sobolev,
  • Iana S. Glazkova,
  • Igor A. Presniakov and ,
  • Valeriy Yu. Verchenko,
  • Joosep Link,
  • Raivo Stern and
  • Andrei V. Shevelkov
  • + 3 authors+ 0 author

15 May 2023

Following the trend of finding better thermoelectric materials among synthetic analogs of copper–chalcogenide minerals, we have synthesized iron-bearing colusites of a general formula Cu26−xFexV2Sn6S32. They crystallize in the cubic space...

(This article belongs to the Special Issue Feature Papers in Compounds (2022–2023))
  • Communication
  • Open Access
2 Citations
2,557 Views
7 Pages

Enzymatic Screening of β-Amyloid Precursor Protein-Based Substrates

  • Reo Yamada,
  • Masaki Midorikawa,
  • Ayu Asai,
  • Norimasa Takasu and ,
  • Ren Fujii and
  • Taeko Kakizawa
  • + 1 author+ 0 author

10 May 2023

We performed an enzymatic screening of synthetic peptides based on β-amyloid precursor protein substrates. The template peptide sequence was a decapeptide derived from our previous screening study, which determined several effective unnatural am...

(This article belongs to the Special Issue Feature Papers in Compounds (2022–2023))
  • Communication
  • Open Access
2 Citations
2,325 Views
5 Pages

18 April 2023

Infinitene was synthesized in a previous study in 2021, and the molecule showed high strain energy. It was not clear how the strain affected the aromatic character of the molecule. To discuss this problem, the aromatic properties of dodecacene, [12]c...

(This article belongs to the Special Issue Feature Papers in Compounds (2022–2023))
  • Review
  • Open Access
26 Citations
7,487 Views
24 Pages

Recent Progress on Natural Rubber-Based Materials Containing Metallic and Metal Oxide Nanoparticles: State of the Art and Biomedical Applications

  • Nayrim B. Guerra,
  • Jordana Bortoluz,
  • Andressa R. Bystronski,
  • Ana Elisa D. Maddalozzo and ,
  • Danielle Restelatto,
  • Mariana Roesch-Ely,
  • Declan M. Devine,
  • Marcelo Giovanela and
  • Janaina S. Crespo
  • + 4 authors+ 0 author

28 March 2023

Diseases caused by infections are becoming harder to treat as the antibiotics used become less effective. A combination of strategies to develop active biomaterials that enhance antibacterial effects are desirable, especially ones that cause fewer si...

(This article belongs to the Special Issue (Bio)molecules from Natural Extracts: An Infinite World of Opportunities)
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Compounds - ISSN 2673-6918